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CALML5 Antibody

  • 中文名稱:
    CALML5兔多克隆抗體
  • 貨號(hào):
    CSB-PA030035
  • 規(guī)格:
    ¥1090
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    CALL5_HUMAN antibody; CALML5 antibody; Calmodulin like 5 antibody; Calmodulin-like protein 5 antibody; Calmodulin-like skin protein antibody; CLSP antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from the C-terminal region of Human CALML5.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Binds calcium. May be involved in terminal differentiation of keratinocytes.
  • 基因功能參考文獻(xiàn):
    1. CALML5 interacts with SFN in suprabasal epidermis, cocontrols 13% of late differentiation genes, and modulates interaction of SFN to some of its binding partners. PMID: 26545810
    2. CLSP is increased in the upper epidermis in exacerbated atopic dermatitis as compared to non-exacerbated atopic dermatitis and normal skin, revealing a role in re-establishing the epidermal barrier PMID: 24279918
    3. Ubiquitination of CALML5 in the nucleus is involved in the carcinogenesis of breast cancer in premenopausal women. PMID: 24146193
    4. CLSP is a physiological heterotrimeric humanin receptor agonist. PMID: 23519124
    5. An investigation of the cation-binding properties of CLSP and the ensuing conformational changes finds that, with its high- and low-affinity Ca+2+-binding sites and a pronounced effect of Mg2+, CLSP is more similar to troponin C than to calmodulin. PMID: 11969404
    6. abnormal elevated levels of CLSP, characteristic of psoriatic epidermis, were probably not due to an overexpression of the protein, but most likely the result of its non-degradation PMID: 16689864
    7. The structure and dynamics of human calmodulin-like skin protein (CLSP) have been characterized by NMR spectroscopy. PMID: 16765896

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  • 組織特異性:
    Particularly abundant in the epidermis where its expression is directly related to keratinocyte differentiation. Very low expression in lung.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 18180

    OMIM: 605183

    KEGG: hsa:51806

    STRING: 9606.ENSP00000369689

    UniGene: Hs.180142



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