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  4. CALML5 Antibody

CALML5 Antibody

  • 中文名稱：
    CALML5兔多克隆抗體
  • 貨號：
    CSB-PA873713DSR1HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA873713DSR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA873713DSR1HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) CALML5 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    CALL5_HUMAN antibody; CALML5 antibody; Calmodulin like 5 antibody; Calmodulin-like protein 5 antibody; Calmodulin-like skin protein antibody; CLSP antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Calmodulin-like protein 5 protein (1-146AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Binds calcium. May be involved in terminal differentiation of keratinocytes.
  • 基因功能參考文獻：
    1. CALML5 interacts with SFN in suprabasal epidermis, cocontrols 13% of late differentiation genes, and modulates interaction of SFN to some of its binding partners. PMID: 26545810
    2. CLSP is increased in the upper epidermis in exacerbated atopic dermatitis as compared to non-exacerbated atopic dermatitis and normal skin, revealing a role in re-establishing the epidermal barrier PMID: 24279918
    3. Ubiquitination of CALML5 in the nucleus is involved in the carcinogenesis of breast cancer in premenopausal women. PMID: 24146193
    4. CLSP is a physiological heterotrimeric humanin receptor agonist. PMID: 23519124
    5. An investigation of the cation-binding properties of CLSP and the ensuing conformational changes finds that, with its high- and low-affinity Ca+2+-binding sites and a pronounced effect of Mg2+, CLSP is more similar to troponin C than to calmodulin. PMID: 11969404
    6. abnormal elevated levels of CLSP, characteristic of psoriatic epidermis, were probably not due to an overexpression of the protein, but most likely the result of its non-degradation PMID: 16689864
    7. The structure and dynamics of human calmodulin-like skin protein (CLSP) have been characterized by NMR spectroscopy. PMID: 16765896

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  • 組織特異性：
    Particularly abundant in the epidermis where its expression is directly related to keratinocyte differentiation. Very low expression in lung.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18180

    OMIM: 605183

    KEGG: hsa:51806

    STRING: 9606.ENSP00000369689

    UniGene: Hs.180142



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