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CALML5 Antibody

  • 中文名稱:
    CALML5兔多克隆抗體
  • 貨號:
    CSB-PA873713HA01HU
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: CALML5 antibody at 2μg/ml + A431 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 16 kDa
      Observed band size: 16 kDa
    • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA873713HA01HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) CALML5 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    CALL5_HUMAN antibody; CALML5 antibody; Calmodulin like 5 antibody; Calmodulin-like protein 5 antibody; Calmodulin-like skin protein antibody; CLSP antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Calmodulin-like protein 5 protein (2-146AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,CALML5 Antibody (CSB-PA873713HA01HU),的標記方式是Non-conjugated。對于CALML5 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA873713HB01HU CALML5 Antibody, HRP conjugated ELISA
    FITC CSB-PA873713HC01HU CALML5 Antibody, FITC conjugated
    Biotin CSB-PA873713HD01HU CALML5 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:200-1:1000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Binds calcium. May be involved in terminal differentiation of keratinocytes.
  • 基因功能參考文獻:
    1. CALML5 interacts with SFN in suprabasal epidermis, cocontrols 13% of late differentiation genes, and modulates interaction of SFN to some of its binding partners. PMID: 26545810
    2. CLSP is increased in the upper epidermis in exacerbated atopic dermatitis as compared to non-exacerbated atopic dermatitis and normal skin, revealing a role in re-establishing the epidermal barrier PMID: 24279918
    3. Ubiquitination of CALML5 in the nucleus is involved in the carcinogenesis of breast cancer in premenopausal women. PMID: 24146193
    4. CLSP is a physiological heterotrimeric humanin receptor agonist. PMID: 23519124
    5. An investigation of the cation-binding properties of CLSP and the ensuing conformational changes finds that, with its high- and low-affinity Ca+2+-binding sites and a pronounced effect of Mg2+, CLSP is more similar to troponin C than to calmodulin. PMID: 11969404
    6. abnormal elevated levels of CLSP, characteristic of psoriatic epidermis, were probably not due to an overexpression of the protein, but most likely the result of its non-degradation PMID: 16689864
    7. The structure and dynamics of human calmodulin-like skin protein (CLSP) have been characterized by NMR spectroscopy. PMID: 16765896

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  • 組織特異性:
    Particularly abundant in the epidermis where its expression is directly related to keratinocyte differentiation. Very low expression in lung.
  • 數據庫鏈接:

    HGNC: 18180

    OMIM: 605183

    KEGG: hsa:51806

    STRING: 9606.ENSP00000369689

    UniGene: Hs.180142



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