在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Botulinum neurotoxin type C1 Antibody, HRP conjugated

Rare Species
  • 中文名稱:
    Botulinum neurotoxin type C1兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA325596LB01CLQ
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Clostridium botulinum N/A Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    N/A
  • 別名:
    Botulinum neurotoxin type C antibody; BoNT/C antibody; Bontoxilysin-C1 antibody; BoNT/C1 antibody; Botulinum neurotoxin type C1) [Cleaved into: Botulinum neurotoxin C light chain antibody; LC antibody; EC 3.4.24.69); Botulinum neurotoxin C heavy chain antibody; HC)] antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Clostridium botulinum
  • 免疫原:
    Recombinant Clostridium botulinum Botulinum neurotoxin type C1 protein (2-428AA)
  • 免疫原種屬:
    Clostridium botulinum
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Botulinum toxin causes flaccid paralysis by inhibiting neurotransmitter (acetylcholine) release from the presynaptic membranes of nerve terminals of the eukaryotic host skeletal and autonomic nervous system, with frequent heart or respiratory failure. Is unique among characterized BoNTs in having 2 substrates, syntaxin (STX) and SNAP25. Precursor of botulinum neurotoxin C which unlike most BoNTs seems not to have a proteinaceous coreceptor, and instead recognizes 2 different complex polysialylated gangliosides found on neural tissue probably found in synaptic vesicles. Upon synaptic vesicle recycling the toxin is taken up via the endocytic pathway. When the pH of the toxin-containing endosome drops a structural rearrangement occurs so that the N-terminus of the heavy chain (HC) forms pores that allows the light chain (LC) to translocate into the cytosol. Once in the cytosol the disulfide bond linking the 2 subunits is reduced and LC cleaves its target protein on synaptic vesicles, preventing their fusion with the cytoplasmic membrane and thus neurotransmitter release. In vitro the whole toxin only has protease activity after reduction. Electrical stimulation increases uptake of toxin, presumably by transiently exposing a receptor usually found in eukaryotic target synaptic vesicles. Forms ion-conducting channels at around pH 6.1. Requires complex eukaryotic host polysialogangliosides for full neurotoxicity. Synaptic vesicle glycoproteins (SV2) do not seem to act as its receptor.; Has proteolytic activity. After translocation into the eukaryotic host cytosol, inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves syntaxin-1A/STX1A and syntaxin-1B/STX1B. Cleaves the '253-Arg-|-Ala-254' bond of STX1 and the '252-Arg-|-Ala-253' bond of STX2; also acts on syntaxin 3 (STX3) but not 4 (STX4). Cleaves the '198-Arg-|-Ala-199' bond of SNAP25. Recognizes the '93-Asn--Met-202' region of SNAP25.; Responsible for host epithelial cell transcytosis, host nerve cell targeting and translocation of light chain (LC) into eukaryotic host cytosol. Composed of 3 subdomains; the translocation domain (TD), and N-terminus and C-terminus of the receptor-binding domain (RBD). The RBD is responsible for the adherence of the toxin to the eukaryotic target cell surface. It simultaneously recognizes 2 polysialated gangliosides coreceptors in close proximity on host synaptic vesicles. The N-terminus of the TD wraps an extended belt around the perimeter of the LC, protecting Zn(2+) in the active site; it may also prevent premature LC dissociation from the translocation channel and protect toxin prior to translocation. The TD inserts into synaptic vesicle membrane to allow translocation into the host cytosol. The C-terminal half of the HC (residues 864-1291) binds neurons in a dose-dependent manner. The C-terminal half of the HC (residues 863-1291) binds eukaryotic host gangliosides in the order GD1b > GT1b > GD1a > GM1a. Has 2 ganglioside binding sites; Sia-1 prefers a sia7 sialic acid and sugars within the ganglioside (GD1b > GT1b), whereas GBP2 recognizes a sia5 sialic acid (GT1b and GD1a). Both sites are required for HC to enter neurons, acting via different gangliosides. This suggests that 2 gangliosides serve as toxin receptors. Synaptic activity (depolarization with K(+)) increases uptake by neurons. Treatment of synaptosomes with proteinase K does not reduce HC binding, suggesting there is no protein receptor or it is protected from extracellular proteases. Decreases uptake and toxicity of whole BoNT/A, but also interferes with uptake of BoNT/E and BoNT/F. HC also binds phosphoinositides, which might play a role in membrane-binding.
  • 亞細胞定位:
    [Botulinum neurotoxin type C]: Secreted.; [Botulinum neurotoxin C light chain]: Secreted.; [Botulinum neurotoxin C heavy chain]: Secreted.
  • 蛋白家族:
    Peptidase M27 family


主站蜘蛛池模板: 国产精品国产对白熟妇| 精品无码国产自产拍在线观看蜜| 欲香欲色天天天综合和网| 久久香综合精品久久伊人| 欧美精品a∨在线观看| 少妇又色又紧又爽又刺激视频| 尤物精品国产第一福利网站| 午夜精品久久久久久毛片| 伊人久久大香线蕉亚洲| 国产高清乱理伦片| 亚洲国产无套无码av电影| 国产成人久久婷婷精品流白浆 | a在线观看免费网站大全| 中文字幕高清免费日韩视频在线| 欧美人与物videos另类xxxxx | 秋霞无码久久久精品交换| 精品乱码一区二区三四五区| 无码人妻精一区二区三区| 亚洲精品国产精品乱码不卡| 无码人妻一区二区中文| 亚洲线精品一区二区三区| 免费人成在线观看视频播放| 日韩精品一区二区三区影院| 成人无码视频在线观看网址| 青青草原综合久久大伊人精品| 女人被狂躁c到高潮视频| 国产在线精品99一卡2卡| 国产成人av综合久久视色| 亚洲国产精品一区二区成人片| 欧洲熟妇色xxxxx欧美老妇伦| 国产亚洲产品影视在线产品| 波多野结衣超清无码专区| 中文无码乱人伦中文视频在线| 麻豆乱码国产一区二区三区| 狠狠色成人一区二区三区| 日韩一区二区三免费高清| 国产精品无码专区| 少妇一夜三次一区二区| 亚洲精品一区二区国产精华液 | 久久理论片午夜琪琪电影网| 国产又大又硬又粗|