在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Botulinum neurotoxin type C1 Antibody, FITC conjugated

Rare Species
  • 中文名稱:
    Botulinum neurotoxin type C1兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA325596LC01CLQ
  • 規(guī)格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Clostridium botulinum N/A Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    N/A
  • 別名:
    Botulinum neurotoxin type C antibody; BoNT/C antibody; Bontoxilysin-C1 antibody; BoNT/C1 antibody; Botulinum neurotoxin type C1) [Cleaved into: Botulinum neurotoxin C light chain antibody; LC antibody; EC 3.4.24.69); Botulinum neurotoxin C heavy chain antibody; HC)] antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Clostridium botulinum
  • 免疫原:
    Recombinant Clostridium botulinum Botulinum neurotoxin type C1 protein (2-428AA)
  • 免疫原種屬:
    Clostridium botulinum
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Botulinum toxin causes flaccid paralysis by inhibiting neurotransmitter (acetylcholine) release from the presynaptic membranes of nerve terminals of the eukaryotic host skeletal and autonomic nervous system, with frequent heart or respiratory failure. Is unique among characterized BoNTs in having 2 substrates, syntaxin (STX) and SNAP25. Precursor of botulinum neurotoxin C which unlike most BoNTs seems not to have a proteinaceous coreceptor, and instead recognizes 2 different complex polysialylated gangliosides found on neural tissue probably found in synaptic vesicles. Upon synaptic vesicle recycling the toxin is taken up via the endocytic pathway. When the pH of the toxin-containing endosome drops a structural rearrangement occurs so that the N-terminus of the heavy chain (HC) forms pores that allows the light chain (LC) to translocate into the cytosol. Once in the cytosol the disulfide bond linking the 2 subunits is reduced and LC cleaves its target protein on synaptic vesicles, preventing their fusion with the cytoplasmic membrane and thus neurotransmitter release. In vitro the whole toxin only has protease activity after reduction. Electrical stimulation increases uptake of toxin, presumably by transiently exposing a receptor usually found in eukaryotic target synaptic vesicles. Forms ion-conducting channels at around pH 6.1. Requires complex eukaryotic host polysialogangliosides for full neurotoxicity. Synaptic vesicle glycoproteins (SV2) do not seem to act as its receptor.; Has proteolytic activity. After translocation into the eukaryotic host cytosol, inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves syntaxin-1A/STX1A and syntaxin-1B/STX1B. Cleaves the '253-Arg-|-Ala-254' bond of STX1 and the '252-Arg-|-Ala-253' bond of STX2; also acts on syntaxin 3 (STX3) but not 4 (STX4). Cleaves the '198-Arg-|-Ala-199' bond of SNAP25. Recognizes the '93-Asn--Met-202' region of SNAP25.; Responsible for host epithelial cell transcytosis, host nerve cell targeting and translocation of light chain (LC) into eukaryotic host cytosol. Composed of 3 subdomains; the translocation domain (TD), and N-terminus and C-terminus of the receptor-binding domain (RBD). The RBD is responsible for the adherence of the toxin to the eukaryotic target cell surface. It simultaneously recognizes 2 polysialated gangliosides coreceptors in close proximity on host synaptic vesicles. The N-terminus of the TD wraps an extended belt around the perimeter of the LC, protecting Zn(2+) in the active site; it may also prevent premature LC dissociation from the translocation channel and protect toxin prior to translocation. The TD inserts into synaptic vesicle membrane to allow translocation into the host cytosol. The C-terminal half of the HC (residues 864-1291) binds neurons in a dose-dependent manner. The C-terminal half of the HC (residues 863-1291) binds eukaryotic host gangliosides in the order GD1b > GT1b > GD1a > GM1a. Has 2 ganglioside binding sites; Sia-1 prefers a sia7 sialic acid and sugars within the ganglioside (GD1b > GT1b), whereas GBP2 recognizes a sia5 sialic acid (GT1b and GD1a). Both sites are required for HC to enter neurons, acting via different gangliosides. This suggests that 2 gangliosides serve as toxin receptors. Synaptic activity (depolarization with K(+)) increases uptake by neurons. Treatment of synaptosomes with proteinase K does not reduce HC binding, suggesting there is no protein receptor or it is protected from extracellular proteases. Decreases uptake and toxicity of whole BoNT/A, but also interferes with uptake of BoNT/E and BoNT/F. HC also binds phosphoinositides, which might play a role in membrane-binding.
  • 亞細胞定位:
    [Botulinum neurotoxin type C]: Secreted.; [Botulinum neurotoxin C light chain]: Secreted.; [Botulinum neurotoxin C heavy chain]: Secreted.
  • 蛋白家族:
    Peptidase M27 family


主站蜘蛛池模板: 亚洲成色在线综合网站| 久久综合亚洲色一区二区三区 | 亚洲国产精品va在线观看麻豆| 久久97久久97精品免视看| 成人精品一区日本无码网| 中文幕无线码中文字蜜桃| 欧美日韓性视頻在線| 色欲香天天综合网站| 国产农村妇女毛片精品久久| 国产精品vⅰdeoxxxx国产| 日韩精品无码免费专区午夜不卡| 国产亚洲精品久久久久久彩霞| 国产成人精品aa毛片| 国产成人一区二区三区别| 韩国无码av片在线观看| 加勒比中文无码久久综合色 | 中文成人在线| 久久综合给综合给久久| 国产三级精品三级在线专1| 香蕉久久人人爽人人爽人人片av| 99re热这里只有精品视频| 国产精品成人永久在线| 免费啪视频在线观看视频网页| 国产偷窥熟女精品视频大全| 少妇高潮喷潮久久久影院| 久久久久国产精品人妻aⅴ四季 | 国产无遮挡免费真人视频在线观看| 国产无吗一区二区三区在线欢| 国产成人精品一区二三区在线观看| 强被迫伦姧惨叫人妻系列| 中文字幕一区日韩精品| 午夜精品射精入后重之免费观看| 国产乱子伦农村xxxx| 亚洲精品午夜无码专区| 色偷偷人人澡久久超碰97| 无码精品国产va在线观看| 无码国产精成人午夜视频一区二区 | 9re热国产这里只有精品| 真实国产乱子伦在线视频| 宅女午夜福利免费视频| 激情综合色综合久久综合|