在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ADCY6 Antibody

ADCY6 Antibody

  • 中文名稱：
    ADCY6兔多克隆抗體
  • 貨號(hào)：
    CSB-PA001342GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    AC6 antibody; ACVI antibody; ADCY 6 antibody; Adcy6 antibody; ADCY6_HUMAN antibody; ADCYB antibody; Adenylate cyclase 6 antibody; Adenylate cyclase type 6 antibody; Adenylate cyclase type VI antibody; Adenylyl cyclase 6 antibody; ATP pyrophosphate lyase 6 antibody; ATP pyrophosphate-lyase 6 antibody; Ca(2+) inhibitable adenylyl cyclase antibody; Ca(2+)-inhibitable adenylyl cyclase antibody; DKFZp779F075 antibody; EC 4.6.1.1 antibody; KIAA0422 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human ADCY6
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors. Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells. Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion. Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function. Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol. Contributes to bone cell responses to mechanical stimuli.
  • 基因功能參考文獻(xiàn)：
    1. rs3730071G/T and rs77913913G/T of ADCY6 were non-polymorphic with respect to HAPE. PMID: 29443612
    2. model suggests Cys1004 in AC6 (subunit C2) and Cys174 in Galphas present at the AC-Galphas interface as the possible residues that might undergo reversible nitrosylation. Docking analysis predicted novel ligands of AC6 that include forskolin-based compounds and its derivatives. PMID: 29327289
    3. Sickle cell anemia patients carrying at least one allele of adcy6 rs3730070-G exhibited lower hemolytic rate than non-carriers in univariate analysis (p=0.006). PMID: 27067484
    4. Mutations in CNTNAP1 and ADCY6 are responsible for severe arthrogryposis multiplex congenita with axoglial defects PMID: 24319099
    5. AC6 localizes in lipid raft fractions of bronchial airway smooth muscle where it is stimulated by beta2 adrenergic- and prostacyclin receptors and inhibited by divalent calcium ions. PMID: 21228062
    6. In addition to its direct effect on renin gene transcription, PPARgamma "sensitizes" renin gene to cAMP via trans-activation of AC6 gene. PMID: 20861226
    7. identified a single nucleotide polymorphism that may play a role in developing left ventricular hypertrophy PMID: 14871025
    8. Raf1 potentiates drug-stimulated cyclic AMP accumulation in cells expressing adenyl cyclcase 6 after activation of multiple signaling pathways. PMID: 15470083
    9. A2bR signals through adenylate cyclase (AC) 6 isoform in intestinal epithelial cells PMID: 16631311
    10. AC6 overexpression in endothelial cells may have use as a means to enhance prostacyclin function and reduce endothelial barrier permeability. PMID: 16885208
    11. These data show that, in an animal model that mimics key aspects of clinical congestive heart failure, cardiac gene transfer of ACVI increases function of the failing heart. PMID: 17007567
    12. Expression of a novel, relatively common variant of ADCY6 parallels an increase in adenylyl cyclase activity and adenylyl cyclase-mediated function in humans. PMID: 17916776
    13. Parathyroid hormone communicates with IP(3)R via "cAMP junctions" that allow local delivery of a supramaximal concentration of cAMP to IP(3)R, directly increasing their sensitivity to IP(3). PMID: 18936250
    14. The catalytic domains (C1 and C2) of adenylate cyclase 6 play a role in targeting adenylate cyclase 6 to lipid rafts. PMID: 19007881
    15. Instead the knock down of the predominant subtype AC6 in HUVECs provided the first direct evidence that the Ca(2+)-mediated inhibition of AC6 accounts for the thrombin-induced decrease in cAMP levels. PMID: 19546162

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Lethal congenital contracture syndrome 8 (LCCS8)
  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein. Cell projection, cilium. Cell projection, stereocilium.
  • 蛋白家族：
    Adenylyl cyclase class-4/guanylyl cyclase family
  • 組織特異性：
    Detected in peripheral blood mononuclear leukocytes (at protein level). Detected in thyroid.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 237

    OMIM: 600294

    KEGG: hsa:112

    STRING: 9606.ENSP00000311405

    UniGene: Hs.525401



主站蜘蛛池模板： 中文字幕无码精品亚洲35| 国产成人a无码短视频| 国产成人精品无码免费看| 成人性能视频在线| 真实国产乱子伦对白视频不卡| 中国人妻被两个老外三p| 国产剧情无码播放在线观看| 农民人伦一区二区三区| 国产精品亚洲一区二区在线观看| 亚洲日韩精品射精日| 久久精品女同亚洲女同| 国产精品免费看久久久| 福利视频在线播放| 国产成人免费无庶挡视频| 国色天香社区在线视频 | 国产午夜草莓视频在线观看 | 久久五月精品中文字幕| 国产高潮流白浆免费观看| 高中生粉嫩无套第一次| 92国产精品午夜福利免费| 色五月五月丁香亚洲综合网| 人妻出轨av中文字幕| 午夜影视免费x看| 国产免费mv大片人人电影播放器| 成人精品一区日本无码网站| 永久免费无码网站在线观看个 | 国产精品麻豆欧美日韩ww| 人人爽人人爽人人片av| 一边做一边喷17p亚洲乱妇50p| 国精产品一区一区三区| 阳茎伸入女人阳道视频免费| 青青草国产免费久久久| 国产亚洲精品a片久久久| 国产乱色精品成人免费视频| 国产喷水1区2区3区咪咪爱av| 久久久久久久久久久免费精品| 国内精品视频一区二区三区 | 五月花成人网| 欧美极p品少妇的xxxxx| 亚洲色素色无码专区| 久久亚洲精品11p|