在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ADCY6 Antibody, HRP conjugated

  • 中文名稱:
    ADCY6兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA001342LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ADCY6 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    AC6 antibody; ACVI antibody; ADCY 6 antibody; Adcy6 antibody; ADCY6_HUMAN antibody; ADCYB antibody; Adenylate cyclase 6 antibody; Adenylate cyclase type 6 antibody; Adenylate cyclase type VI antibody; Adenylyl cyclase 6 antibody; ATP pyrophosphate lyase 6 antibody; ATP pyrophosphate-lyase 6 antibody; Ca(2+) inhibitable adenylyl cyclase antibody; Ca(2+)-inhibitable adenylyl cyclase antibody; DKFZp779F075 antibody; EC 4.6.1.1 antibody; KIAA0422 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Adenylate cyclase type 6 protein (9-118AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors. Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells. Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion. Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function. Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol. Contributes to bone cell responses to mechanical stimuli.
  • 基因功能參考文獻:
    1. rs3730071G/T and rs77913913G/T of ADCY6 were non-polymorphic with respect to HAPE. PMID: 29443612
    2. model suggests Cys1004 in AC6 (subunit C2) and Cys174 in Galphas present at the AC-Galphas interface as the possible residues that might undergo reversible nitrosylation. Docking analysis predicted novel ligands of AC6 that include forskolin-based compounds and its derivatives. PMID: 29327289
    3. Sickle cell anemia patients carrying at least one allele of adcy6 rs3730070-G exhibited lower hemolytic rate than non-carriers in univariate analysis (p=0.006). PMID: 27067484
    4. Mutations in CNTNAP1 and ADCY6 are responsible for severe arthrogryposis multiplex congenita with axoglial defects PMID: 24319099
    5. AC6 localizes in lipid raft fractions of bronchial airway smooth muscle where it is stimulated by beta2 adrenergic- and prostacyclin receptors and inhibited by divalent calcium ions. PMID: 21228062
    6. In addition to its direct effect on renin gene transcription, PPARgamma "sensitizes" renin gene to cAMP via trans-activation of AC6 gene. PMID: 20861226
    7. identified a single nucleotide polymorphism that may play a role in developing left ventricular hypertrophy PMID: 14871025
    8. Raf1 potentiates drug-stimulated cyclic AMP accumulation in cells expressing adenyl cyclcase 6 after activation of multiple signaling pathways. PMID: 15470083
    9. A2bR signals through adenylate cyclase (AC) 6 isoform in intestinal epithelial cells PMID: 16631311
    10. AC6 overexpression in endothelial cells may have use as a means to enhance prostacyclin function and reduce endothelial barrier permeability. PMID: 16885208
    11. These data show that, in an animal model that mimics key aspects of clinical congestive heart failure, cardiac gene transfer of ACVI increases function of the failing heart. PMID: 17007567
    12. Expression of a novel, relatively common variant of ADCY6 parallels an increase in adenylyl cyclase activity and adenylyl cyclase-mediated function in humans. PMID: 17916776
    13. Parathyroid hormone communicates with IP(3)R via "cAMP junctions" that allow local delivery of a supramaximal concentration of cAMP to IP(3)R, directly increasing their sensitivity to IP(3). PMID: 18936250
    14. The catalytic domains (C1 and C2) of adenylate cyclase 6 play a role in targeting adenylate cyclase 6 to lipid rafts. PMID: 19007881
    15. Instead the knock down of the predominant subtype AC6 in HUVECs provided the first direct evidence that the Ca(2+)-mediated inhibition of AC6 accounts for the thrombin-induced decrease in cAMP levels. PMID: 19546162

    顯示更多

    收起更多

  • 相關疾病:
    Lethal congenital contracture syndrome 8 (LCCS8)
  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein. Cell projection, cilium. Cell projection, stereocilium.
  • 蛋白家族:
    Adenylyl cyclase class-4/guanylyl cyclase family
  • 組織特異性:
    Detected in peripheral blood mononuclear leukocytes (at protein level). Detected in thyroid.
  • 數據庫鏈接:

    HGNC: 237

    OMIM: 600294

    KEGG: hsa:112

    STRING: 9606.ENSP00000311405

    UniGene: Hs.525401



主站蜘蛛池模板: 国产精品嫩草99av在线| 亚洲乱码日产精品bd在线| 色欲来吧来吧天天综合网| 国产av久久人人澡人人爱| 国产99视频精品免费专区| 小说区亚洲综合第1页| 国内精品乱码卡一卡2卡| 国产成人一区二区青青草原| 国产精品亚洲mnbav网站| 久久久橹橹橹久久久久| 国产精品无码一区二区三区在| 久久人妻天天av| 解开人妻的裙子猛烈进入| 国产a√精品区二区三区四区| 中文字幕无码日韩欧免费软件| 国产八十老太另类| 久久不见久久见免费视频观看| 18禁止看的免费污网站| 大学生高潮无套内谢视频| 一出一进一爽一粗一大视频免费的| 精品国产国语对白久久免费| 别揉我奶头~嗯~啊~一区二区三区| 日韩aⅴ人妻无码一区二区| 国产午夜毛片v一区二区三区| 国产精品无码一区二区在线| 久久香蕉综合色一综合色88| 国产农村毛卡片| 日本黄页网站免费大全| 大地资源网中文第五页| 久久综合亚洲色hezyo国产| 十八禁真人啪啪免费网站| 人妻系列无码专区无码中出| 朝鲜女人大白屁股ass孕交| 国产精品无码成人午夜电影| 天天天天做夜夜夜夜做无码| 国产免费久久精品99reswag | 影音先锋久久久久av综合网成人| 亚洲a∨无码无在线观看| 婷婷久久综合九色综合| 成人午夜福利院在线观看| 日韩久久久久久中文人妻|