在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ADCY6 Antibody, Biotin conjugated

  • 中文名稱:
    ADCY6兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA001342LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ADCY6 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    AC6 antibody; ACVI antibody; ADCY 6 antibody; Adcy6 antibody; ADCY6_HUMAN antibody; ADCYB antibody; Adenylate cyclase 6 antibody; Adenylate cyclase type 6 antibody; Adenylate cyclase type VI antibody; Adenylyl cyclase 6 antibody; ATP pyrophosphate lyase 6 antibody; ATP pyrophosphate-lyase 6 antibody; Ca(2+) inhibitable adenylyl cyclase antibody; Ca(2+)-inhibitable adenylyl cyclase antibody; DKFZp779F075 antibody; EC 4.6.1.1 antibody; KIAA0422 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Adenylate cyclase type 6 protein (9-118AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors. Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells. Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion. Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function. Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol. Contributes to bone cell responses to mechanical stimuli.
  • 基因功能參考文獻:
    1. rs3730071G/T and rs77913913G/T of ADCY6 were non-polymorphic with respect to HAPE. PMID: 29443612
    2. model suggests Cys1004 in AC6 (subunit C2) and Cys174 in Galphas present at the AC-Galphas interface as the possible residues that might undergo reversible nitrosylation. Docking analysis predicted novel ligands of AC6 that include forskolin-based compounds and its derivatives. PMID: 29327289
    3. Sickle cell anemia patients carrying at least one allele of adcy6 rs3730070-G exhibited lower hemolytic rate than non-carriers in univariate analysis (p=0.006). PMID: 27067484
    4. Mutations in CNTNAP1 and ADCY6 are responsible for severe arthrogryposis multiplex congenita with axoglial defects PMID: 24319099
    5. AC6 localizes in lipid raft fractions of bronchial airway smooth muscle where it is stimulated by beta2 adrenergic- and prostacyclin receptors and inhibited by divalent calcium ions. PMID: 21228062
    6. In addition to its direct effect on renin gene transcription, PPARgamma "sensitizes" renin gene to cAMP via trans-activation of AC6 gene. PMID: 20861226
    7. identified a single nucleotide polymorphism that may play a role in developing left ventricular hypertrophy PMID: 14871025
    8. Raf1 potentiates drug-stimulated cyclic AMP accumulation in cells expressing adenyl cyclcase 6 after activation of multiple signaling pathways. PMID: 15470083
    9. A2bR signals through adenylate cyclase (AC) 6 isoform in intestinal epithelial cells PMID: 16631311
    10. AC6 overexpression in endothelial cells may have use as a means to enhance prostacyclin function and reduce endothelial barrier permeability. PMID: 16885208
    11. These data show that, in an animal model that mimics key aspects of clinical congestive heart failure, cardiac gene transfer of ACVI increases function of the failing heart. PMID: 17007567
    12. Expression of a novel, relatively common variant of ADCY6 parallels an increase in adenylyl cyclase activity and adenylyl cyclase-mediated function in humans. PMID: 17916776
    13. Parathyroid hormone communicates with IP(3)R via "cAMP junctions" that allow local delivery of a supramaximal concentration of cAMP to IP(3)R, directly increasing their sensitivity to IP(3). PMID: 18936250
    14. The catalytic domains (C1 and C2) of adenylate cyclase 6 play a role in targeting adenylate cyclase 6 to lipid rafts. PMID: 19007881
    15. Instead the knock down of the predominant subtype AC6 in HUVECs provided the first direct evidence that the Ca(2+)-mediated inhibition of AC6 accounts for the thrombin-induced decrease in cAMP levels. PMID: 19546162

    顯示更多

    收起更多

  • 相關疾病:
    Lethal congenital contracture syndrome 8 (LCCS8)
  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein. Cell projection, cilium. Cell projection, stereocilium.
  • 蛋白家族:
    Adenylyl cyclase class-4/guanylyl cyclase family
  • 組織特異性:
    Detected in peripheral blood mononuclear leukocytes (at protein level). Detected in thyroid.
  • 數據庫鏈接:

    HGNC: 237

    OMIM: 600294

    KEGG: hsa:112

    STRING: 9606.ENSP00000311405

    UniGene: Hs.525401



主站蜘蛛池模板: 日产精品卡二卡三卡四卡区满十八| 欧美变态另类牲交zozo| 欧美日韩无套内射另类| 性xxxxx欧美极品少妇| 亚洲熟女av综合网五月| 欧美人妻日韩精品| 高清精品一区二区三区| 天堂在线www资源在线| 亚洲精品揄拍自拍首页一| 国产精品高清一区二区三区| 护士的小嫩嫩好紧好爽| 亚洲精品久久国产精品浴池| 人妻体验按摩到忍不住哀求继续 | 久久99精品久久只有精品| 欧美午夜精品一区二区三区电影| 成人毛片无码免费播放网站| 亚洲精品拍拍央视网出文| 暴力强奷在线播放无码| 国产特级毛片aaaaaa高潮流水| 国产男女无遮挡猛进猛出| www激情内射在线看| 亚洲va中文字幕无码一二三区| 亚洲丁香婷婷久久一区二区| 欧美激情一区二区三区在线| 在线高清理伦片a| 亚洲最大的熟女水蜜桃av网站| 欧美精品一区二区黄a片| 中文在线8资源库| 伊人久久成综合久久影院| 久热中文字幕无码视频| 久久久久久久综合狠狠综合 | 国产无套精品一区二区| 丰满熟妇人妻中文字幕| 国产精品久久久久久免费软件| 国产亚洲精品久久久久久彩霞| 天天摸夜夜添狠狠添婷婷| 97人妻人人揉人人躁人人| 成人免费无遮挡在线播放| 国产成人精选在线观看不卡| 亚洲一卡二卡三卡四卡| 色婷婷六月亚洲婷婷丁香|