Recombinant Mouse Activin receptor type-2A (Acvr2a), partial (Active)

^{In Stock}

貨號：

CSB-MP001260MO1
規格：

￥684
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Mouse Acvr2a at 2 μg/ml can bind Anti-ACVR2A&ACVR2B recombinant antibody (CSB-RA623829MA1HU). The EC₅₀ is 1.562-1.966 ng/mL. Biological Activity Assay

The purity of ACVR2A was greater than 95% as determined by SEC-HPLC
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靶點詳情

產品詳情

純度：

Greater than 95% as determined by SDS-PAGE.
Greater than 95% as determined by SEC-HPLC.
生物活性：

Measured by its binding ability in a functional ELISA. Immobilized Mouse ACVR2A at 2 μg/mL can bind Anti-ACVR2A recombinant antibody (CSB-RA623829MA1HU). The EC50 is 1.562-1.966 ng/mL.
基因名：

ACVR2A
Uniprot No.：

P27038
別名：

Activin receptor type-2A; EC:2.7.11.30; Activin receptor type IIA (ACTR-IIA); Acvr2a; Acvr2
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
來源：

Mammalian cell
分子量：

14.8 kDa
表達區域：

20-135aa
氨基酸序列

AILGRSETQECLFFNANWERDRTNQTGVEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTDCIEKKDSPEVYFCCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPP
蛋白標簽：

C-terminal?10xHis-tagged
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from a 0.2 μm filtered PBS, 6% Trehalose, pH 7.4
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6.
基因功能參考文獻：
1. Activation of ActRIIA signaling during early chronic kidney disease contributes to the CKD-MBD components of osteodystrophy and cardiovascular disease and to renal fibrosis. PMID: 28843411
2. blocking activin/ACVR2A impaired the potency of hepatic stellate cells to produce collagens in response to IL17s. PMID: 29620144
3. Anti-ActRII blockade is an effective intervention against cancer cachexia providing benefit even in the presence of anti-cancer therapies. PMID: 27462398
4. Data, including data from studies using transgenic mice, suggest that osteoblasts deficient in Acvr2A exhibit un-characteristic features; osteoclasts deficient in Acvr2A or Acvr2B or both appear normal. Acvr2A-deficient mice exhibit significantly increased femoral trabecular bone volume at 6 weeks of age; Acvr2B-deficient mice exhibit no significant change in any bone parameter. PMID: 28659341
5. miR-125b regulated the activin/Smad2 signaling in neonatal mouse ovary by directly targeting the 3'-untranslated region of activin receptor type 2a PMID: 26962113
6. Our study shows that a miR-590/Acvr2a/Rad51b signaling axis ensures the stabilization of mESCs by balancing DNA damage repair and rapid proliferation during self-renewal. PMID: 25458897
7. Bmpr2 and Acvr2a normally play cell-type-specific, necessary roles in organelle biogenesis and the shutdown of developmental programs and cell division. PMID: 22611050
8. Acvr2a is a Th17 specific gene making Th17 cells distinct from other helper T cells, Th1, Th2, and Treg. PMID: 22056434
9. stimulates expression of APRIL via the Smad3 and ERK/CREB pathways in macrophages PMID: 21784102
10. Results demonstrated that BMPRII and ActRII are the functional type II TGF-beta receptors in BMP-9-induced osteogenic differentiation of C3H10T1/2 cells. PMID: 20801928
11. The coordinated activity of ActRIIA and BMPRII receptor subunits selectively mediates the chemotactic response to BMP7. PMID: 20011660
12. Activin type IIB(ActRIIB) and its subfamily receptor, Activin type IIA (ActRIIA), cooperatively mediate the Gdf11 signal in patterning the axial vertebrae PMID: 12414726
13. analysis of expression and cellular compartmentalization of the activin receptors ActRIIA, ActRIIB and ActRIB, the inhibin co-receptor (betaglycan), and activin signaling proteins Smads 2, 3 and 4, and growth regulatory role during lactation PMID: 12782414
14. Data suggest that activin receptor II signaling is critical only for follicle-stimulating hormone homeostasis and not for gonadotrophin-releasing hormone (GnRH)biosynthesis or induction of pituitary GnRH receptor expression. PMID: 14654247
15. Overexpression of ARIP2 enhances endocytosis of ActRIIAs; data indicate that ARIP2 is a novel factor regulating cell surface ActRIIA expression and activin function. PMID: 15451561
16. loss of Bmpr2 leads to the net gain of signaling by some, but not all, BMP ligands via the activation of ActRIIa PMID: 15883158
17. ActRIIa is expressed in the early development of thymocytes. PMID: 16477644
18. RGMa facilitates the use of ActRIIA by endogenous BMP2 and BMP4 ligands that otherwise prefer signaling via BMPRII and that increased utilization of ActRIIA leads to generation of an enhanced BMP signal PMID: 17472960
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亞細胞定位：

Membrane; Single-pass type I membrane protein.
蛋白家族：

Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
組織特異性：

Brain, testis, intestine, liver and kidney.
數據庫鏈接：

KEGG: mmu:11480

STRING: 10090.ENSMUSP00000067305

UniGene: Mm.314338