在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Activin receptor type-2A (Acvr2a)

  • 中文名稱:
    Recombinant Mouse Activin receptor type-2A(Acvr2a)
  • 貨號:
    CSB-CF001260MO
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    Acvr2a; Acvr2; Activin receptor type-2A; Activin receptor type IIA; ACTR-IIA
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    20-513
  • 氨基酸序列
    AILGRSETQECLFFNANWERDRTNQTGVEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTDCIEKKDSPEVYFCCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGPPPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6.
  • 基因功能參考文獻:
    1. Activation of ActRIIA signaling during early chronic kidney disease contributes to the CKD-MBD components of osteodystrophy and cardiovascular disease and to renal fibrosis. PMID: 28843411
    2. blocking activin/ACVR2A impaired the potency of hepatic stellate cells to produce collagens in response to IL17s. PMID: 29620144
    3. Anti-ActRII blockade is an effective intervention against cancer cachexia providing benefit even in the presence of anti-cancer therapies. PMID: 27462398
    4. Data, including data from studies using transgenic mice, suggest that osteoblasts deficient in Acvr2A exhibit un-characteristic features; osteoclasts deficient in Acvr2A or Acvr2B or both appear normal. Acvr2A-deficient mice exhibit significantly increased femoral trabecular bone volume at 6 weeks of age; Acvr2B-deficient mice exhibit no significant change in any bone parameter. PMID: 28659341
    5. miR-125b regulated the activin/Smad2 signaling in neonatal mouse ovary by directly targeting the 3'-untranslated region of activin receptor type 2a PMID: 26962113
    6. Our study shows that a miR-590/Acvr2a/Rad51b signaling axis ensures the stabilization of mESCs by balancing DNA damage repair and rapid proliferation during self-renewal. PMID: 25458897
    7. Bmpr2 and Acvr2a normally play cell-type-specific, necessary roles in organelle biogenesis and the shutdown of developmental programs and cell division. PMID: 22611050
    8. Acvr2a is a Th17 specific gene making Th17 cells distinct from other helper T cells, Th1, Th2, and Treg. PMID: 22056434
    9. stimulates expression of APRIL via the Smad3 and ERK/CREB pathways in macrophages PMID: 21784102
    10. Results demonstrated that BMPRII and ActRII are the functional type II TGF-beta receptors in BMP-9-induced osteogenic differentiation of C3H10T1/2 cells. PMID: 20801928
    11. The coordinated activity of ActRIIA and BMPRII receptor subunits selectively mediates the chemotactic response to BMP7. PMID: 20011660
    12. Activin type IIB(ActRIIB) and its subfamily receptor, Activin type IIA (ActRIIA), cooperatively mediate the Gdf11 signal in patterning the axial vertebrae PMID: 12414726
    13. analysis of expression and cellular compartmentalization of the activin receptors ActRIIA, ActRIIB and ActRIB, the inhibin co-receptor (betaglycan), and activin signaling proteins Smads 2, 3 and 4, and growth regulatory role during lactation PMID: 12782414
    14. Data suggest that activin receptor II signaling is critical only for follicle-stimulating hormone homeostasis and not for gonadotrophin-releasing hormone (GnRH)biosynthesis or induction of pituitary GnRH receptor expression. PMID: 14654247
    15. Overexpression of ARIP2 enhances endocytosis of ActRIIAs; data indicate that ARIP2 is a novel factor regulating cell surface ActRIIA expression and activin function. PMID: 15451561
    16. loss of Bmpr2 leads to the net gain of signaling by some, but not all, BMP ligands via the activation of ActRIIa PMID: 15883158
    17. ActRIIa is expressed in the early development of thymocytes. PMID: 16477644
    18. RGMa facilitates the use of ActRIIA by endogenous BMP2 and BMP4 ligands that otherwise prefer signaling via BMPRII and that increased utilization of ActRIIA leads to generation of an enhanced BMP signal PMID: 17472960

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
  • 組織特異性:
    Brain, testis, intestine, liver and kidney.
  • 數據庫鏈接:


主站蜘蛛池模板: 少妇一边呻吟一边说使劲视频| 亚洲乱亚洲乱少妇无码| 真人做作爱视频| 久久国产乱子伦精品免费午夜 | 毛片完整版的免费观看| 真实国产精品视频400部| 亚洲aⅴ天堂av天堂无码| 精品一二三区久久aaa片| 韩国三级丰满少妇高潮| 国产人妻人伦精品1国产| 国产99在线 | 免费| 东北老女人高潮大喊舒服死了| 超清无码波多野吉衣中文 | 中文无码av在线亚洲电影| 四虎影视永久免费观看| 久久777国产线看观看精品 | 18禁无遮挡羞羞污污污污免费| 亚洲中文精品久久久久久 | 国产超碰人人做人人爱ⅴa | 2020精品国产自在现线看| 国内大量揄拍人妻在线视频| 亚洲精品国产成人无码区a片| 曰韩无码二三区中文字幕| 亚洲人亚洲精品成人网站| 国产在线 | 欧洲| 天天躁夜夜躁狠狠躁2021| 色屁屁www影院免费观看| 妺妺窝人体色www婷婷| 亚洲欧洲美色一区二区三区| 国色天香网www在线观看| 天干夜天天夜天干天2004年| 亚洲精品乱码久久久久久蜜桃| 少妇内射兰兰久久| 久久综合久久自在自线精品自| 精品综合久久久久久8888| 精品无码人妻一区二区三区不卡| 黄在线看片免费人成视频| 国产三级aⅴ在在线观看| 肥臀熟女一区二区三区| 日本大乳高潮视频在线观看| 久久久喷潮一区二区三区|