在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Ephrin type-A receptor 8 (EPHA8), partial (Active)

Unavailable
  • 中文名稱:
    人EPHA8重組蛋白
  • 貨號:
    CSB-AP005581HU
  • 規格:
    ¥702
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 95% as determined by SDS-PAGE.
  • 內毒素:
    Less than 1.0 EU/μg as determined by LAL method.
  • 生物活性:
    The ED50 as determined by its ability to bind Mouse Ephrin-A5 in functional ELISA is less than 40 ug/ml.
  • 基因名:
    EPHA8
  • Uniprot No.:
  • 別名:
    EPHA8; EEK; HEK3; KIAA1459Ephrin type-A receptor 8; EC 2.7.10.1; EPH- and ELK-related kinase; EPH-like kinase 3; EK3; hEK3; Tyrosine-protein kinase receptor EEK
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 來源:
    Mammalian cell
  • 分子量:
    78.4 kDa
  • 表達區域:
    28-495aa
  • 氨基酸序列
    ARGEVNLLDTSTIHGDWGWLTYPAHGWDSINEVDESFQPIHTYQVCNVMSPNQNNWLRTSWVPRDGARRVYAEIKFTLRDCNSMPGVLGTCKETFNLYYLESDRDLGASTQESQFLKIDTIAADESFTGADLGVRRLKLNTEVRSVGPLSKRGFYLAFQDIGACLAILSLRIYYKKCPAMVRNLAAFSEAVTGADSSSLVEVRGQCVRHSEERDTPKMYCSAEGEWLVPIGKCVCSAGYEERRDACVACELGFYKSAPGDQLCARCPPHSHSAAPAAQACHCDLSYYRAALDPPSSACTRPPSAPVNLISSVNGTSVTLEWAPPLDPGGRSDITYNAVCRRCPWALSRCEACGSGTRFVPQQTSLVQASLLVANLLAHMNYSFWIEAVNGVSDLSPEPRRAAVVNITTNQAAPSQVVVIRQERAGQTSVSLLWQEPEQPNGIILEYEIKYYEKDKEMQSYSTLKAVTT
  • 蛋白標簽:
    C-terminal hFc-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from a 0.2 μm filtered 20 mM PB, 150 mM NaCl, pH 7.4
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth.
  • 基因功能參考文獻:
    1. Q-PCR and IHC staining revealed that EphA8 was highly expressed in OTSCC tissues, especially in advanced stage OTSCC tissues. Kaplan-Meier curve showed that high EphA8 expression was significantly associated with poor prognosis. PMID: 30300334
    2. High EPHA8 expression is associated with epithelial ovarian cancer. PMID: 26989075
    3. Human miR-10a and EphA8 regulate epithelial-mesenchymal transition (EMT) to affect glioma cell migration and invasion. PMID: 25683004
    4. RINL, as a GEF for Rab5 subfamily, is implicated in the EphA8-degradation pathway via its interaction with odin. PMID: 22291991
    5. role in stimulated cell migration in presnce of p110 gamma PI-3 kinase PMID: 12681484
    6. EphA8 receptor is capable of inducing a sustained increase in MAPK activity, thereby promoting neurite outgrowth in neuronal cells PMID: 15782114

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein. Cell projection. Early endosome membrane.
  • 蛋白家族:
    Protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily
  • 數據庫鏈接:

    HGNC: 3391

    OMIM: 176945

    KEGG: hsa:2046

    STRING: 9606.ENSP00000166244

    UniGene: Hs.283613



主站蜘蛛池模板: 在线综合亚洲欧美网站| 国偷自产一区二区三区在线视频| 无码av片在线观看免费| 精品卡1卡2卡三卡免费网站| 久久国产乱子精品免费女| 天天综合色天天综合色hd| 亚洲a无码综合a国产av中文| 久久精品aⅴ无码中文字字幕重口| 日本熟妇人妻xxxxx| 不卡无码av一区二区三区| 国产精品女同一区二区在线| 欧美性猛少妇xxxxx免费| 毛片无码免费无码播放| 亚洲精品永久在线观看| 色狠狠av一区二区三区| 四虎影视无码永久免费| 九九热爱视频精品视频16| 欧美性白人极品1819hd| 少妇人妻邻居| 亚洲欧洲日产国码久在线| 最新的国产成人精品2022| 黑人巨大白妞出浆| 国产成人精品亚洲777人妖| 精品夜夜爽欧美毛片视频 | 久欠精品国国产99国产精2021| 久久婷婷是五月综合色| 欧美性白人极品hd| 自慰小少妇毛又多又黑流白浆| 国产在线精品一区二区在线看| 美女扒开腿让男人桶爽揉| 久久大香国产成人av| 中文字幕人乱码中文字幕| 中文字幕亚洲无线码一区女同 | 日韩人妻不卡一区二区三区| 伊人久久精品无码二区麻豆| 国产午夜毛片v一区二区三区| 色翁荡息又大又硬又粗又爽| 无码人妻精品丰满熟妇区| 麻豆果冻传媒2021精品传媒一区下载 | 国产激情无码一区二区| 国产开嫩苞实拍在线播放视频|