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  4. Human Thyroxine-Binding Globulin,TBG ELISA Kit

Human Thyroxine-Binding Globulin,TBG ELISA Kit

  • 中文名稱：
    人甲狀腺結合球蛋白(TBG)酶聯免疫試劑盒
  • 貨號：
    CSB-E09501h
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    人甲狀腺結合球蛋白(TBG)酶聯免疫試劑盒（CSB-E09501h）為競爭法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的SERPINA7含量。SERPINA7是一個靶點。它可能在生理病理過程扮演重要角色，目前對其具體背景研究或許與特定疾病相關，研究機制方面可能涉及在體內的信號傳導、與其他分子的相互作用等方面，不過因缺乏更多信息，其確切詳情還待進一步深入探索。試劑盒檢測范圍為12.5 ng/mL-200 ng/mL，適用于實驗室研究甲狀腺功能疾病（如甲亢、甲減、甲狀腺炎）的分子機制、激素代謝調控通路探索，或藥物開發中靶向TBG的作用效果評估本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    Serine (or cysteine) proteinase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 7 ELISA Kit; Serpin A7 ELISA Kit; Serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 7 ELISA Kit; Serpin peptidase inhibitor, clade A, member 7 ELISA Kit; Serpina7 ELISA Kit; T4 binding globulin ELISA Kit; TBG ELISA Kit; TBG, serum ELISA Kit; THBG_HUMAN ELISA Kit; Thyroxin binding globulin ELISA Kit; Thyroxine binding globulin ELISA Kit; Thyroxine-binding globulin ELISA Kit; Thyroxine-binding globulin od serum ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    12.5 ng/mL-200 ng/mL
  • 靈敏度：
    12.5 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Others
  • 測定原理：
    quantitative
  • 測定方法：
    Competitive
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<15%      
    Three samples of known concentration were tested twenty times on one plate to assess.  
    Inter-assay Precision (Precision between assays): CV%<15%      
    Three samples of known concentration were tested in twenty assays to assess.    
                 
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human TBG in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)  
    1:1 Average % 91  
    Range % 85-96  
    1:2 Average % 96  
    Range % 92-105  
    1:4 Average % 84  
    Range % 80-89  
    1:8 Average % 91  
    Range % 85-98  
  • 回收率：
    The recovery of human TBG spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range  
    Serum (n=5) 91 87-95  
    EDTA plasma (n=4) 96 90-102  
                 
                 
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average    
    200 0.121 0.115 0.118    
    100 0.328 0.328 0.328    
    50 0.513 0.312 0.413    
    25 1.015 0.497 0.756    
    12.5 2.116 2.121 2.119    
  • 數據處理：
  • 貨期：
    3-5 working days

引用文獻

產品評價

相關問答

■ 常見問題解答
Q:

I need a TBG ELISA that would work for recombinant TBG in cell culture supernatant. Is this kit suitable for that?

A:
Thanks for your inquiry.
CSB-E09501H
The standard in this kit is CHO-derived recombinant protein. As we are not clear about the expression system and modifications of recombinant TBG, sorry we are not sure if it can be detected out or not. For this case we can only suggest you do a pretest first. We validated natural samples before and they can be detected out.

靶點詳情

  • 功能：
    Major thyroid hormone transport protein in serum.
  • 基因功能參考文獻：
    1. A new SERPINA7 variant associated with thyroxine-binding globulin deficiency in three siblings. PMID: 29733970
    2. THBG is a potential plasma biomarker for COPD. PMID: 28579773
    3. mutation in a liver-specific enhancer region of the TBG gene caused inherited TBG deficiency. To our knowledge, the present study is the first report of an inherited endocrine disorder caused by a mutation in an enhancer region. PMID: 25361180
    4. TBG allosteric regulation is entropy driven. The presence of multiple S states may allow more efficient T4 release due to protease activity. PMID: 23458682
    5. the TBG promoter has a role in sustaining transgene expression in liver-specific pattern PMID: 22820390
    6. Allosteric modulation of hormone release from thyroxine and corticosteroid-binding globulins. PMID: 21325280
    7. Freshly isolated TBG-Chicago exists in loop expelled conformation. At 37C, the protein readily converts to a more stable loop inserted conformation with enhanced heat stability. PMID: 20429632
    8. an intragenic A/G polymorphism (125 bp upstream from exon 2) was identified. complete TBG deficiency was homozygous for the polymorphic TBG allele. PMID: 11889160
    9. Two novel variants in the thyroxine-binding globulin gene behind the diagnosis of TBG deficiency. homozygous. One involved codon 23 (TCA-->TAA) and the other, codon 223. PMID: 11916615
    10. Loop variants of the serpin thyroxine-binding globulin: implications for hormone release upon limited proteolysis. PMID: 11931635
    11. guanine deletion at position 1711, codon 201 (Asp) in exon 2 (GAC --> AC) led to a frame shift and premature termination at codon 206, causing a short TBG protein of 205 amino acids (AA) compared to 395 AA of the normal TBG. PMID: 17887925
    12. new serpina7 gene variant in three members of the same family results in the replacement of the normal asparagine 233 by isoleucine and, subsequently, in disruption of a glycosylation site PMID: 19415532
    13. The first exon (exon 0) is a short noncoding sequence located 1.62 kilobase pairs (kbp) upstream from exon 1. HNF-1 site (located 65 bp upstream of the TSS) is required for the hepatocyte specific expression of the hTBG gene. PMID: 8232304

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Serpin family
  • 組織特異性：
    Expressed by the liver and secreted in plasma.
  • 數據庫鏈接：

    HGNC: 11583

    OMIM: 300932

    KEGG: hsa:6906

    STRING: 9606.ENSP00000329374

    UniGene: Hs.76838



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