在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 試劑盒
  3. 酶聯免疫試劑盒
  4. Human Thyroxine-Binding Globulin,TBG ELISA Kit

Human Thyroxine-Binding Globulin,TBG ELISA Kit

  • 中文名稱：
    人甲狀腺結合球蛋白(TBG)酶聯免疫試劑盒
  • 貨號：
    CSB-E09501h
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    人甲狀腺結合球蛋白(TBG)酶聯免疫試劑盒（CSB-E09501h）為競爭法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的SERPINA7含量。SERPINA7是一個靶點。它可能在生理病理過程扮演重要角色，目前對其具體背景研究或許與特定疾病相關，研究機制方面可能涉及在體內的信號傳導、與其他分子的相互作用等方面，不過因缺乏更多信息，其確切詳情還待進一步深入探索。試劑盒檢測范圍為12.5 ng/mL-200 ng/mL，適用于實驗室研究甲狀腺功能疾病（如甲亢、甲減、甲狀腺炎）的分子機制、激素代謝調控通路探索，或藥物開發中靶向TBG的作用效果評估本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    Serine (or cysteine) proteinase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 7 ELISA Kit; Serpin A7 ELISA Kit; Serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 7 ELISA Kit; Serpin peptidase inhibitor, clade A, member 7 ELISA Kit; Serpina7 ELISA Kit; T4 binding globulin ELISA Kit; TBG ELISA Kit; TBG, serum ELISA Kit; THBG_HUMAN ELISA Kit; Thyroxin binding globulin ELISA Kit; Thyroxine binding globulin ELISA Kit; Thyroxine-binding globulin ELISA Kit; Thyroxine-binding globulin od serum ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    12.5 ng/mL-200 ng/mL
  • 靈敏度：
    12.5 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Others
  • 測定原理：
    quantitative
  • 測定方法：
    Competitive
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<15%      
    Three samples of known concentration were tested twenty times on one plate to assess.  
    Inter-assay Precision (Precision between assays): CV%<15%      
    Three samples of known concentration were tested in twenty assays to assess.    
                 
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human TBG in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)  
    1:1 Average % 91  
    Range % 85-96  
    1:2 Average % 96  
    Range % 92-105  
    1:4 Average % 84  
    Range % 80-89  
    1:8 Average % 91  
    Range % 85-98  
  • 回收率：
    The recovery of human TBG spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range  
    Serum (n=5) 91 87-95  
    EDTA plasma (n=4) 96 90-102  
                 
                 
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average    
    200 0.121 0.115 0.118    
    100 0.328 0.328 0.328    
    50 0.513 0.312 0.413    
    25 1.015 0.497 0.756    
    12.5 2.116 2.121 2.119    
  • 數據處理：
  • 貨期：
    3-5 working days

引用文獻

產品評價

相關問答

■ 常見問題解答
Q:

I need a TBG ELISA that would work for recombinant TBG in cell culture supernatant. Is this kit suitable for that?

A:
Thanks for your inquiry.
CSB-E09501H
The standard in this kit is CHO-derived recombinant protein. As we are not clear about the expression system and modifications of recombinant TBG, sorry we are not sure if it can be detected out or not. For this case we can only suggest you do a pretest first. We validated natural samples before and they can be detected out.

靶點詳情

  • 功能：
    Major thyroid hormone transport protein in serum.
  • 基因功能參考文獻：
    1. A new SERPINA7 variant associated with thyroxine-binding globulin deficiency in three siblings. PMID: 29733970
    2. THBG is a potential plasma biomarker for COPD. PMID: 28579773
    3. mutation in a liver-specific enhancer region of the TBG gene caused inherited TBG deficiency. To our knowledge, the present study is the first report of an inherited endocrine disorder caused by a mutation in an enhancer region. PMID: 25361180
    4. TBG allosteric regulation is entropy driven. The presence of multiple S states may allow more efficient T4 release due to protease activity. PMID: 23458682
    5. the TBG promoter has a role in sustaining transgene expression in liver-specific pattern PMID: 22820390
    6. Allosteric modulation of hormone release from thyroxine and corticosteroid-binding globulins. PMID: 21325280
    7. Freshly isolated TBG-Chicago exists in loop expelled conformation. At 37C, the protein readily converts to a more stable loop inserted conformation with enhanced heat stability. PMID: 20429632
    8. an intragenic A/G polymorphism (125 bp upstream from exon 2) was identified. complete TBG deficiency was homozygous for the polymorphic TBG allele. PMID: 11889160
    9. Two novel variants in the thyroxine-binding globulin gene behind the diagnosis of TBG deficiency. homozygous. One involved codon 23 (TCA-->TAA) and the other, codon 223. PMID: 11916615
    10. Loop variants of the serpin thyroxine-binding globulin: implications for hormone release upon limited proteolysis. PMID: 11931635
    11. guanine deletion at position 1711, codon 201 (Asp) in exon 2 (GAC --> AC) led to a frame shift and premature termination at codon 206, causing a short TBG protein of 205 amino acids (AA) compared to 395 AA of the normal TBG. PMID: 17887925
    12. new serpina7 gene variant in three members of the same family results in the replacement of the normal asparagine 233 by isoleucine and, subsequently, in disruption of a glycosylation site PMID: 19415532
    13. The first exon (exon 0) is a short noncoding sequence located 1.62 kilobase pairs (kbp) upstream from exon 1. HNF-1 site (located 65 bp upstream of the TSS) is required for the hepatocyte specific expression of the hTBG gene. PMID: 8232304

    顯示更多

    收起更多

  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Serpin family
  • 組織特異性：
    Expressed by the liver and secreted in plasma.
  • 數據庫鏈接：

    HGNC: 11583

    OMIM: 300932

    KEGG: hsa:6906

    STRING: 9606.ENSP00000329374

    UniGene: Hs.76838



主站蜘蛛池模板： 亚洲va久久久噜噜噜久久男同| 茄子视频国产在线观看| 午夜影视免费| 亚洲一区二区观看播放| 小辣椒福利视频导航| 国产精品久久无码不卡| ww欧日韩视频高清在线| 国产亚洲精品久久久久久老妇小说 | 亚洲成av人综合在线观看| 欧美性黑人极品hd另类| 国产成久久免费精品av片| 亚洲精品国产精品乱码不卡√| 白天躁晚上躁麻豆视频| 九九视频国产免| 亚洲日韩va在线视频| 国精一二二产品无人区免费应用| 久久这里只有精品18| 精品一区二区三人妻视频| 久久狼人大香伊蕉国产| 欧美老熟妇乱xxxxx| 三男一女吃奶添下面视频| 免费香蕉成视频人网站| 熟女人妻高清一区二区三区| 午夜无码国产理论在线| 国产精品久久久久9999| 综合色区亚洲熟妇另类| 午夜国人精品av免费看| 成人无码精品免费视频在线观看| 亚洲第一无码xxxxxx| 波多野结衣 黑人| 日韩精品无码免费专区网站| 男女一边摸一边做爽爽的免费阅读| 少妇又色又紧又爽又刺激视频| 色综合欧美在线视频区| 九九热线精品视频16| 国产超级va在线观看视频| 国产98色在线 | 日韩| 精品人妻无码专区中文字幕| 麻豆丰满少妇chinese| 麻花传媒mv国产免费观看视频| 欧美又大粗又爽又黄大片视频 |