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Human Myelin P2 protein (PMP2) ELISA kit

  • 中文名稱:
    人髓磷脂P2蛋白(PMP2)酶聯免疫試劑盒
  • 貨號:
    CSB-E09601h
  • 規格:
    96T/48T
  • 價格:
    ¥3600/¥2500
  • 其他:

產品詳情

  • 產品描述:
    人髓磷脂P2蛋白(PMP2)酶聯免疫試劑盒(CSB-E09601h)檢測樣本中的PMP2含量。本試劑盒適用于多種生物樣本的檢測(具體適用樣本類型需根據實驗需求確認);可滿足基礎科研中PMP2蛋白表達水平分析、疾病模型機制探究以及藥物干預效果評估等需求,例如在吉蘭 - 巴雷綜合征、Charcot - Marie - Tooth病等神經病變研究中的應用。本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
  • 別名:
    FABP8 ELISA Kit; M FABP ELISA Kit; MP2 ELISA Kit; Myelin FABP ELISA Kit; Myelin P2 protein ELISA Kit; MYP2_HUMAN ELISA Kit; P2 ELISA Kit; Peripheral myelin protein 2 ELISA Kit; PMP2 ELISA Kit
  • 縮寫:
    PMP2
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 檢測范圍:
    Request Information
  • 靈敏度:
    Request Information
  • 反應時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領域:
    Cardiovascular
  • 貨期:
    3-5 working days

產品評價

靶點詳情

  • 功能:
    May play a role in lipid transport protein in Schwann cells. May bind cholesterol.
  • 基因功能參考文獻:
    1. The structural characterization of the F57A mutant of P2 which shows changes in the portal region and helix alpha2 and an unfolded status upon lipid bilayer binding. Further results suggest a central role for Phe57 in regulating the opening of the portal region in human P2, and the F57A mutation disturbs dynamic cross-correlation networks in the portal region of P2. PMID: 29940944
    2. SH3TC2, PMP2, and BSCL2 pathogenic variants might be rare in Chinese Charcot-Marie-Tooth (CMT) patients. PMID: 29336362
    3. Our genetic and clinical findings in these kindred demonstrate that dominant PMP2 mutations cause Charcot-Marie- Tooth disease type 1. PMID: 27009151
    4. A fully deuterated sample of myelin P2 protein was produced identifying the neutron crystal structure. PMID: 26527266
    5. This report might expand the genetic and clinical features of Charcot-Marie-Tooth disease and a further mechanism study will enhance our understanding of PMP2-associated peripheral neuropathy. PMID: 26828946
    6. The structure of human P2 refined at the ultrahigh resolution of 0.93 A allows detailed structural analyses, including the full organization of an internal hydrogen-bonding network. PMID: 24419389
    7. the structure and function of the P2 protein from human myelin, which is able to bind both monomeric lipids inside its cavity and membrane surfaces PMID: 20421974

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  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    Calycin superfamily, Fatty-acid binding protein (FABP) family
  • 數據庫鏈接:

    HGNC: 9117

    OMIM: 170715

    KEGG: hsa:5375

    STRING: 9606.ENSP00000256103

    UniGene: Hs.571512



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