在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 試劑盒
  3. 酶聯免疫試劑盒
  4. Human Ectonucleotide pyrophosphatase/phosphodiesterase family member 3(ENPP3) ELISA kit

Human Ectonucleotide pyrophosphatase/phosphodiesterase family member 3(ENPP3) ELISA kit

  • 中文名稱：
    人膜外核苷酸焦磷酸酶/磷酸二酯酶家族成員3(ENPP3)酶聯免疫試劑盒
  • 貨號：
    CSB-EL007681HU
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    人膜外核苷酸焦磷酸酶/磷酸二酯酶家族成員3(ENPP3)酶聯免疫試劑盒（CSB-EL007681HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、細胞裂解物樣本中的ENPP3含量。ENPP3 作為一個靶點，在眾多疾病研究中備受關注。其背景與細胞信號傳導、腫瘤微環境等密切相關。研究機制方面，它參與調節細胞內外的核苷酸代謝，還可能影響腫瘤細胞的增殖、遷移等過程，為相關疾病的治療提供了重要潛在靶點。試劑盒檢測范圍為0.156 ng/mL-10 ng/mL，適用于基礎科研中ENPP3蛋白表達的動態監測，如探究其在腫瘤微環境、免疫調節或代謝性疾病模型中的功能機制，也可用于細胞實驗、動物模型或生物樣本庫中ENPP3水平的系統性比較研究，為分子機制探索提供可靠數據支持。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    Alkaline phosphodiesterase I ELISA Kit; ARHR2 ELISA Kit; B10 ELISA Kit; CD203c ELISA Kit; CD203c antigen ELISA Kit; dJ1005H11.3 (phosphodiesterase I/nucleotide pyrophosphatase 3) ELISA Kit; dJ914N13.3 (phosphodiesterase I/nucleotide pyrophosphatase 3) ELISA Kit; E NPP 3 ELISA Kit; E-NPP 3 ELISA Kit; Ectonucleotide pyrophosphatase/phosphodiesterase 3 ELISA Kit; Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 ELISA Kit; ENPP3 ELISA Kit; ENPP3_HUMAN ELISA Kit; gp130RB13 6 ELISA Kit; gp130RB136 ELISA Kit; M6S1 ELISA Kit; NPP1 ELISA Kit; NPP3 ELISA Kit; NPPase ELISA Kit; NPPS ELISA Kit; Nucleotide pyrophosphatase ELISA Kit; PC 1 ELISA Kit; PC-1 ELISA Kit; PCA1 ELISA Kit; PD Ibeta ELISA Kit; PD-Ibeta ELISA Kit; PDNP1 ELISA Kit; PDNP3 ELISA Kit; Phosphodiesterase I beta ELISA Kit; Phosphodiesterase I/nucleotide pyrophosphatase 3 ELISA Kit; phosphodiesterase i/nucleotide pyrophosphatase beta ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍：
    0.156 ng/mL-10 ng/mL
  • 靈敏度：
    0.039 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Epigenetics and Nuclear Signaling
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human ENPP3 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 97
    Range % 93-101
    1:2 Average % 99
    Range % 92-105
    1:4 Average % 89
    Range % 83-94
    1:8 Average % 91
    Range % 87-96
  • 回收率：
    The recovery of human ENPP3 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 104 98-109
    EDTA plasma (n=4) 85 80-90
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average Corrected
    10 2.755 2.858 2.807 2.691
    5 2.212 2.221 2.217 2.101
    2.5 1.537 1.477 1.507 1.391
    1.25 0.946 0.954 0.950 0.834
    0.625 0.489 0.473 0.481 0.365
    0.312 0.289 0.274 0.282 0.166
    0.156 0.210 0.218 0.214 0.098
    0 0.115 0.116 0.116 　
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP. Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells. Has also alkaline phosphodiesterase activity.
  • 基因功能參考文獻：
    1. We showed the ability of the immunological marker CD203c to predict the clinical efficacy of sublingual immunotherapy on rhinitis subjects allergic to Parietaria. PMID: 29702283
    2. Basophil CD203c surface expression reliably discriminated cystic fibrosis with allergic bronchopulmonary aspergillosis from cystic fibrosis with Aspergillus colonization and cystic fibrosis over time. PMID: 26585435
    3. Expression of CD203c on basophils as a marker of immunoglobulin E-mediated (L)-asparaginase allergy. PMID: 23581640
    4. Anaphylactic transfusion reaction in homozygous haptoglobin deficiency detected by CD203c expression on basophils. PMID: 24497482
    5. ENPP3 is a regulator of N-acetylglucosaminyltransferase GnT-IX (GnT-Vb) PMID: 23960081
    6. The early signaling requirements for the CD11b/CD203c compartment expression and CD63 degranulation provide support for the hypothesis that CD11b and CD203c reside in a similar compartment. PMID: 22722613
    7. Subjects with nut allergy show an increase of basophil CD203c levels at baseline and following rapid ex vivo stimulation with nut allergen PMID: 20975283
    8. Asthma exacerbation was accompanied by increased expression of CD203c on basophils that decreased significantly during remission PMID: 20159259
    9. Influence of hyperosmotic conditions on basophil CD203c upregulation in patients with food-dependent exercise-induced anaphylaxis. PMID: 20047266
    10. Data show that low and high dilutions of histamine inhibit CD203c up-regulation in anti-IgE stimulated basophils. PMID: 19418203
    11. E-NPP3 is associated with carcinogenesis of human colon cancer and that serum E-NPP3 might be a tumor marker of colon carcinoma PMID: 14533006
    12. E-NPP3 is involved in the infiltration of neoplastic bile duct carcinoma PMID: 15072822
    13. Our data demonstrate that leptin promotes platelet activation, provides a mechanistic basis for the prothrombotic effect of this hormone, and identifies a potentially novel therapeutic avenue to limit obesity-associated cardiovascular disease. PMID: 15886225
    14. In conclusion, using well-defined experimental conditions, the measurement of CD203c up-regulation on basophils in response to specific allergens is as reliable as CD63-BAT for the in vitro diagnosis of patients with IgE-mediated allergy. PMID: 17275019

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Single-pass type II membrane protein. Apical cell membrane; Single-pass type II membrane protein. Secreted.
  • 蛋白家族：
    Nucleotide pyrophosphatase/phosphodiesterase family
  • 組織特異性：
    Detected on bile ducts in liver, and in blood serum (at protein level). Detected in prostate and uterus. Detected on basophils, but not neutrophils.
  • 數據庫鏈接：

    HGNC: 3358

    OMIM: 602182

    KEGG: hsa:5169

    STRING: 9606.ENSP00000350265

    UniGene: Hs.486489



主站蜘蛛池模板： 怡春院国产精品视频| 国产一区二区三区乱码| 国产精品亲子乱子伦xxxx裸| 亚洲人成在线观看网站不卡| 亚洲乱码在线卡一卡二卡新区豆瓣 | 久久午夜私人影院| 99久热国产精品视频尤物| 裸身美女无遮挡永久免费视频 | 娜娜麻豆国产电影| 久99久热只有精品国产15| 色婷婷一区二区三区四区成人网| 少妇午夜啪爽嗷嗷叫视频| 午夜男女无遮掩免费视频| 亚洲男人最新版本天堂| 国产乱人伦app精品久久| 亚洲人成网站在线播放小说 | 国产精品白丝av在线观看播放| 思思久久精品一本到99热| 台湾无码一区二区| 人妻无码一区二区不卡无码av| 三级成年网站在线观看级爱网| 办公丝袜av一区二区三区| 男人的天堂2018无码| 又大又粗弄得我出好多水| 国产成人综合欧美精品久久| 玩弄丰满奶水的女邻居| 亚洲精品中文字幕| 国模大胆一区二区三区| 亚洲熟妇久久国产精品| 成人av一本不卡二卡| 两个人看的www视频免费完整版| 中文字幕无码毛片免费看| 久久婷婷色综合老司机| 亚洲熟妇丰满多毛xxxx| 蜜臀aⅴ国产精品久久久国产老师| 国产精品sm捆绑调教视频| 亚洲成av人最新无码| 亚洲精品亚洲人成人网| 国内精品免费久久久久软件| 在线亚洲精品国产成人av剧情| 凹凸国产熟女精品视频app|