在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Human Ecto-NOX disulfide-thiol exchanger 2(ENOX2) ELISA kit

  • 中文名稱:
    人外NOx硫硫醇交換器2(ENOX2)酶聯(lián)免疫試劑盒
  • 貨號:
    CSB-EL007677HU
  • 規(guī)格:
    96T/48T
  • 價格:
    ¥3600/¥2500
  • 其他:

產品詳情

  • 產品描述:
    人外NOx硫硫醇交換器2(ENOX2)酶聯(lián)免疫試劑盒(CSB-EL007677HU)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織勻漿、細胞裂解物樣本中的ENOX2含量。ENOX2是一種編碼細胞表面NADH氧化酶的ECTO-NOX基因家族的腫瘤特異性成員,具有兩種酶活性:對苯二酚或NADH氧化的催化,以及蛋白質二硫化物交換。研究顯示,ENOX2抑制可增強效應記憶T細胞的浸潤并介導對化療的反應,可能成為增強化療效果的有前景的治療策略。試劑盒檢測范圍為31.25 pg/mL-2000 pg/mL,適用于探索ENOX2在腫瘤發(fā)生、代謝性疾病或氧化應激相關機制研究中的表達規(guī)律,如通過檢測體外細胞模型、動物實驗組織或臨床前生物樣本中ENOX2的動態(tài)變化,為分子機制研究提供可靠工具本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
  • 別名:
    APK1 ELISA Kit; APK1 antigen ELISA Kit; COVA1 ELISA Kit; Cytosolic ovarian carcinoma antigen 1 ELISA Kit; Ecto NOX disulfide thiol exchanger 2 ELISA Kit; ENOX 2 ELISA Kit; ENOX2 ELISA Kit; ENOX2_HUMAN ELISA Kit; OTTHUMP00000024021 ELISA Kit; OTTHUMP00000024022 ELISA Kit; Protein disulfide-thiol oxidoreductase ELISA Kit; tNOX ELISA Kit; Tumor associated hydroquinone oxidase ELISA Kit; Tumor-associated hydroquinone oxidase ELISA Kit
  • 縮寫:
    ENOX2
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 樣本類型:
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍:
    31.25 pg/mL-2000 pg/mL
  • 靈敏度:
    7.81 pg/mL
  • 反應時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領域:
    Neuroscience
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 精密度:
    Intra-assay Precision (Precision within an assay): CV%<8%      
    Three samples of known concentration were tested twenty times on one plate to assess.  
    Inter-assay Precision (Precision between assays): CV%<10%      
    Three samples of known concentration were tested in twenty assays to assess.    
                 
  • 線性度:
    To assess the linearity of the assay, samples were spiked with high concentrations of human ENOX2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
      Sample Serum(n=4)  
    1:1 Average % 93  
    Range % 82-97  
    1:2 Average % 98  
    Range % 92-104  
    1:4 Average % 102  
    Range % 96-108  
    1:8 Average % 89  
    Range % 82-95  
  • 回收率:
    The recovery of human ENOX2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range  
    Serum (n=5) 94 90-98  
    EDTA plasma (n=4) 88 82-92  
                 
                 
  • 標準曲線:
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected  
    2000 2.314 2.428 2.371 2.213  
    1000 1.497 1.586 1.542 1.384  
    500 0.937 0.882 0.910 0.752  
    250 0.567 0.553 0.560 0.402  
    125 0.365 0.376 0.371 0.213  
    62.5 0.271 0.264 0.268 0.110  
    31.25 0.218 0.214 0.216 0.058  
    0 0.157 0.158 0.158    
  • 數據處理:
  • 貨期:
    3-5 working days

產品評價

靶點詳情

  • 功能:
    May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock.
  • 基因功能參考文獻:
    1. The tumor-associated NADH oxidase (tNOX)-mediated modulation of the NAD+ concentration and SIRT1 are involved in oxaliplatin-induced apoptosis. PMID: 28122359
    2. These findings not only shed light on the molecular mechanism of the anticancer properties of capsaicin, but also the transcription regulation of tNOX expression that may potentially explain how POU3F2 is associated with tumorigenesis. PMID: 27271588
    3. The findings support a role for arNOX as a major source of oxidative damage leading to cross-linking of skin proteins. PMID: 24906676
    4. The results suggest that phosphorylation of serine-504 by PKCdelta modulates the biological function of tNOX. PMID: 22659163
    5. this result suggests that hnRNP F directs formation of the exon 4 minus variant of ENOX2. PMID: 21625959
    6. increased NADH levels resulting from ENOX2 inhibition result in decreased prosurvival sphingosine-1-phosphate and increased proapoptotic ceramide, both of which may be important to initiation of the ENOX2 inhibitor-induced apoptotic cascade. PMID: 21571040
    7. ENOX2 is a dimeric protein containing 4 coppers/dimer capable of carrying out concerted four electron transfers from NADH or ubiquinol to molecular oxygen as required to form water. PMID: 20922471
    8. arNOX activity correlates with age and reaches a maximum at about age 65 in males and 55 in females. PMID: 20345278
    9. Enhanced arNOX activity correlates with age and with oxidative changes contributing to skin aging. PMID: 19734125
    10. tNOX is both necessary and sufficient for the cellular anticancer activities attributed to both EGCg and capsaicin. *tNOX enzyme PMID: 15706060
    11. results indicate that shRNA targeting of tNOX inhibits the growth of cervical cancer cells, and reduces cell migration via a decrease in the membrane association of Rac. PMID: 18023414
    12. A relationship of tNOX to unregulated growth of cancer cells was provided by data where growth of HeLa cells was inhibited by transfection with the exon 5 antisense oligonucleotides PMID: 18351130
    13. These results indicate that tNOX is suppressed during apoptosis and demonstrate that tNOX down-regulation sensitizes cells to stress-induced growth reduction, suggesting that tNOX is required for transformed cell growth. PMID: 18789934

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane. Secreted, extracellular space. Note=Extracellular and plasma membrane-associated.
  • 蛋白家族:
    ENOX family
  • 組織特異性:
    Found in the sera of cancer patients with a wide variety of cancers including breast, prostate, lung and ovarian cancers, leukemias, and lymphomas. Not found in the serum of healthy volunteers or patients with disorders other than cancer. Probably shed in
  • 數據庫鏈接:

    HGNC: 2259

    OMIM: 300282

    KEGG: hsa:10495

    STRING: 9606.ENSP00000337146

    UniGene: Hs.171458



主站蜘蛛池模板: 国产又粗又硬又大爽黄老大爷视频| 日本高清不卡aⅴ免费网站| 性亚洲videofree高清| 暖暖视频日本| 中文在线а天堂中文在线新版| 98色婷婷在线| 2021年精品国产福利在线| 国产偷窥熟女精品视频 | 一本大道大臿蕉视频无码| 国产成人片无码视频在线观看| 性欧美大战久久久久久久| 国产乱码精品一品二品| 51社区精品视频| 免费大片av手机看片不卡| 内射合集对白在线| 精品国产a∨无码一区二区三区| 综合久久国产九一剧情麻豆| 最近中文字幕mv在线视频看| 亚洲男女一区二区三区| 人妻奶水人妻系列| 色综合天天综合高清网国产在线| 人摸人人人澡人人超碰97| 草草地址线路①屁屁影院成人| 毛片免费全部无码播放| 亚洲第一狼人天堂久久| 亚洲人成日韩中文字幕无卡| 国产免费mv大片人人电影播放器 | 亚洲a成人无m网站在线| 亚洲欧美国产制服图片区| 亚洲国产精品嫩草影院| 久久久无码人妻精品无码| 欧美性群另类交| 亚洲国产婷婷综合在线精品| 男女猛烈无遮挡免费视频| 大肉大捧一进一出视频出来呀 | 丰满少妇被猛烈进入高清播放| 亚洲国产综合av在线观看| 99久久精品费精品国产一区二| 免费观看亚洲人成网站| 久久中文字幕人妻av熟女| 辽宁熟女高潮狂叫视频|