ULBP1
ULBP1，全稱為UL16結(jié)合蛋白1，也被稱為NKG2D配體1。它是一種在免疫系統(tǒng)中發(fā)揮重要作用的蛋白，主要功能是作為NKG2D受體的配體，激活自然殺傷細(xì)胞和T細(xì)胞，從而增強(qiáng)機(jī)體對(duì)腫瘤細(xì)胞的殺傷能力。ULBP1與NKG2D的結(jié)合能夠激活多種免疫信號(hào)通路，如JAK2、STAT5、ERK和PI3K/Akt通路，從而促進(jìn)免疫細(xì)胞的活化。在腫瘤治療領(lǐng)域，ULBP1被作為CAR-T細(xì)胞治療的靶點(diǎn)之一，目前已有針對(duì)ULBP1的CAR-T藥物處于臨床研究階段，顯示出良好的治療潛力。此外，ULBP1還與多種血液和實(shí)體腫瘤相關(guān)，因此，針對(duì)ULBP1的藥物研發(fā)進(jìn)展備受關(guān)注。
熱銷產(chǎn)品
Recombinant Human UL16-binding protein 1 (ULBP1) (Active) (CSB-MP887177HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized KLRK1 (CSB-MP012474HU1) at 10 μg/ml can bind human ULBP1, the EC50 of human ULBP1 protein is 228.5-427.6 ng/ml.
Human KLRK1 protein Fc tag (CSB-MP012474HU1) captured on COOH chip can bind Human ULBP1 protein Fc/myc tag (CSB-MP887177HU) with an affinity constant of 2.27 nM as detected by LSPR Assay.
ULBP1 Recombinant Monoclonal Antibody (CSB-RA446786A0HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, Raji whole cell lysate, HEK293 whole cell lysate
All lanes: ULBP1 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 28 kDa
Observed band size: 36-50 kDa
ULBP1 Antibodies
ULBP1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA025609GA01HU | ULBP1 Antibody | Human | ELISA,WB,IHC |
| CSB-PA887177LA01HU | ULBP1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA887177LB01HU | ULBP1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA887177LC01HU | ULBP1 Antibody, FITC conjugated | Human | |
| CSB-PA887177LD01HU | ULBP1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA446786A0HU | ULBP1 Recombinant Monoclonal Antibody | Human | ELISA, WB |
ULBP1 Proteins
ULBP1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP887177HU CSB-EP887177HU CSB-BP887177HU CSB-EP887177HU-B |
Recombinant Human NKG2D ligand 1 (ULBP1) | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP887177HU | Recombinant Human UL16-binding protein 1 (ULBP1) (Active) | Mammalian cell |
| CSB-MP887177HUj1-B | Recombinant Human UL16-binding protein 1 (ULBP1),Biotinylated (Active) | Mammalian cell |
