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  4. ULBP1 Recombinant Monoclonal Antibody

ULBP1 Recombinant Monoclonal Antibody

  • 中文名稱：
    ULBP1重組抗體
  • 貨號：
    CSB-RA446786A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, Raji whole cell lysate, HEK293 whole cell lysate
      All lanes: ULBP1 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 28 kDa
      Observed band size: 36-50 kDa
  • 其他：

產品詳情

  • 產品描述：
    ULBP1重組單克隆抗體（CUSABIO貨號：CSB-RA446786A0HU）是針對ULBP1蛋白設計的高特異性科研工具，該靶點為自然殺傷細胞活化性受體NKG2D的關鍵配體，廣泛參與腫瘤免疫監視及感染性疾病中的天然免疫應答調控。本抗體經嚴格驗證適用于ELISA和WB等檢測方法，在Western Blot實驗中推薦使用1:500至1:2000的稀釋范圍，可穩定識別目標蛋白并呈現清晰的特異性條帶，實驗結果顯示其具有優異的批間一致性和低交叉反應特性。該產品適用于腫瘤微環境研究、免疫細胞活化機制解析、病毒感染相關免疫逃逸等基礎科研領域，特別在探索NK細胞功能調控、腫瘤免疫逃逸機制或免疫治療靶點篩選等實驗中展現重要應用價值，為體外細胞實驗、蛋白互作研究及病理模型分析提供可靠工具。
  • Uniprot No.：
  • 基因名：
  • 別名：
    UL16-binding protein 1 (ALCAN-beta) (NKG2D ligand 1) (N2DL-1) (NKG2DL1) (Retinoic acid early transcript 1I), ULBP1, N2DL1 RAET1I
  • 反應種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human ULBP1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    13C8
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
  • 基因功能參考文獻：
    1. we show that Simian Virus 40 (SV40)...evades NK cell attack through the down regulation of...ULBP1 PMID: 26992229
    2. ATF4 drives ULBP1 gene expression in cancer cell lines, while the RNA-binding protein RBM4 supports ULBP1 expression by suppressing a novel alternatively spliced isoform of ULBP1 mRNA. PMID: 26565589
    3. expression determines intrinsic acute myeloid leukemia susceptibility to allogeneic V[gamma]9V[delta]2 T cells PMID: 24911793
    4. recurrence-free survival of patients with ULBP1-negative hepatocellular carcinoma (HCC) was significantly shorter than that of patients with ULBP1-positive HCC PMID: 21756848
    5. recombinant ULBP1 fused to CD45 caused a reduction in cytotoxicity and degranulation by NK cells, implying a role for receptor ligand distribution in the activation of NK cell responses PMID: 21464092
    6. Data show that ULBP1, TFR2 and IFITM1 were associated with increased susceptibility to Vgamma9Vdelta2 T-cell cytotoxicity. PMID: 20220060
    7. These results identify Mult1 as a target for the MARCH family of E3 ligases PMID: 20870941
    8. As NKG2D ligand, ULBP1 are expressed on immature dendritic cells and plays an important role in the cytotoxic effect of NK cells against iDC. PMID: 18394338
    9. Data show that the protease NS3/4A of HCV down-regulates ULBP1 expression by inhibiting the transcription of ULBP1. PMID: 19500498
    10. ULBP1 binds to the NKG2D receptor and activates multiple signaling pathways in primary natural killer cells. PMID: 11777960
    11. The NKG2D ligand ULBP1 is up-regulated and readily detectable intracellularly in the endoplasmic reticulum of human cytomegalovirus-infected fibroblasts, where it colocalizes with viral protein UL16. PMID: 12847260
    12. ULBP1 is a human ligand of the NKG2D receptor PMID: 16901903
    13. The selective induction of ULBP1 expression by proteasome inhibitor drugs, along with variable NKG2D ligand expression by human tumor cells, indicates that NKG2D ligand genes are independently regulated. PMID: 19414815

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  • 亞細胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor. Endoplasmic reticulum.
  • 蛋白家族：
    MHC class I family
  • 組織特異性：
    Expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues including heart, brain, lung, liver, testis, lymph node, thymus, tonsil and bone marrow. Also found in fetal heart, brain, lung and liver.
  • 數據庫鏈接：

    HGNC: 14893

    OMIM: 605697

    KEGG: hsa:80329

    STRING: 9606.ENSP00000229708

    UniGene: Hs.653255



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