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TAP1

Antigen peptide transporter 1 is a protein in humans that is encoded by TAP1 gene. Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.

TAP1 Antibodies

TAP1 for Homo sapiens (Human)

TAP1 Proteins

TAP1 Proteins for Homo sapiens (Human)

TAP1 Proteins for Mus musculus (Mouse)

TAP1 Proteins for Rattus norvegicus (Rat)

TAP1 Proteins for Solanum lycopersicum (Tomato) (Lycopersicon esculentum)

TAP1 Proteins for Gorilla gorilla gorilla (Lowland gorilla)



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