STK40
STK40,即絲氨酸/蘇氨酸激酶40,別名SHIK、SgK495。STK40是一種假激酶,具有激酶同源結構域但缺乏催化活性,主要通過作為支架蛋白協助E3泛素連接酶與底物蛋白結合,促進蛋白的泛素化和降解。STK40可調控Th1和Th17細胞的分化,介導炎癥和自身免疫疾病進展中的重要功能,通過促進FOXO轉錄因子與E3連接酶COP1的相互作用,促進K48連接的多泛素化和蛋白酶體降解。STK40在多種生理過程中發揮作用,包括細胞分化、免疫反應調節以及可能的能量代謝調節,其異常表達與多種疾病相關,包括自身免疫性疾病和腫瘤。
熱銷產品
驗證數據

The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA112765(STK40 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA112765(STK40 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)

Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Human placenta tissue, Primary antibody: CSB-PA112765(STK40 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
STK40 Antibodies
STK40 for Homo sapiens (Human)
產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
---|---|---|---|
CSB-PA112765 | STK40 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA158011 | STK40 Antibody | Human,Mouse,Rat | ELISA,IHC |
STK40 Proteins
STK40 Proteins for Homo sapiens (Human)
產品貨號 | 產品名稱 | 來源 |
---|---|---|
CSB-YP854027HU CSB-EP854027HU CSB-BP854027HU CSB-MP854027HU CSB-EP854027HU-B |
Recombinant Human Serine/threonine-protein kinase 40 (STK40) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |