STEAP1
STEAP1,也被稱為前列腺跨膜上皮抗原1,是一種由雄激素誘導并在前列腺癌中高表達的細胞表面抗原。它由6個跨膜螺旋組成,包含339個氨基酸,具有胞內N端和C端結構域,并由三個細胞外環和兩個細胞內環連接。與其他的STEAP不同的是,STEAP1缺乏N末端NADPH-氧化還原酶結構域,因此不獨立地表現出Fe3+或Cu2+還原酶活性,但其C端包含一個b型血紅素輔助因子。此外,STEAP1在尤因肉瘤(EWS)中也高度表達,并且受到EWS-FLI1融合蛋白的調控,該融合蛋白是這種惡性腫瘤的主要致癌驅動因素。在功能上,STEAP1的過表達與惡性前列腺組織有關,但在正常的前列腺組織中表達較低,因此它被視為一個理想的治療靶點,同時也具有作為診斷和預后生物標志物的潛力。值得注意的是,STEAP1還在肺癌的腫瘤血管生成中發揮著重要作用。實體腫瘤的生長主要依賴于腫瘤細胞和腫瘤血管內皮細胞,而STEAP1在肺癌血管生成中的發現為肺癌治療提供了新的思路。
熱銷產品
Recombinant Mus musculus Metalloreductase STEAP1 (Steap1)
驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
STEAP1 Antibodies
STEAP1 for Homo sapiens (Human)
產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
---|---|---|---|
CSB-PA13354A0Rb | STEAP1 Antibody | Human | ELISA, WB, IHC, IF |
CSB-PA13354B0Rb | STEAP1 Antibody, HRP conjugated | Human | ELISA |
CSB-PA13354D0Rb | STEAP1 Antibody, Biotin conjugated | Human | ELISA |
CSB-PA004185 | STEAP1 Antibody | Human | WB, IHC, ELISA |
STEAP1 Proteins
STEAP1 Proteins for Homo sapiens (Human)
產品貨號 | 產品名稱 | 來源 |
---|---|---|
CSB-YP890691HU1 CSB-BP890691HU CSB-EP890691HU1-B |
Recombinant Human STEAP1 protein (STEAP1), partial | Yeast Baculovirus In Vivo Biotinylation in E.coli |
CSB-RP133544h | Recombinant Human Metalloreductase STEAP1 (STEAP1), partial | E.coli |
CSB-CF890691HU | Recombinant Human Metalloreductase STEAP1 (STEAP1) | in vitro E.coli expression system |
CSB-MP890691HU | Recombinant Human STEAP1 protein (STEAP1)-VLPs | Mammalian cell |
CSB-CF890691HUd7 | Recombinant Human STEAP1 protein (STEAP1) | in vitro E.coli expression system |
CSB-EP890691HU | Recombinant Human STEAP1 protein (STEAP1), partial | E.coli |