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Your Good Partner in Biology Research

REL

Proto-oncogene c-Relis a protein in humans that is encoded by REL gene. Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors.

REL Antibodies

REL for Homo sapiens (Human)

REL Proteins

REL Proteins for Gallus gallus (Chicken)

REL Proteins for Mus musculus (Mouse)

REL Proteins for Meleagris gallopavo (Common turkey)

REL Proteins for Drosophila melanogaster (Fruit fly)

REL Proteins for Homo sapiens (Human)



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