在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Drosophila melanogaster Nuclear factor NF-kappa-B p110 subunit (Rel), partial

Recombinant Drosophila melanogaster Nuclear factor NF-kappa-B p110 subunit (Rel), partial

  • 中文名稱：
    黑腹果蠅Rel重組蛋白
  • 貨號：
    CSB-YP856705DLU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    黑腹果蠅Rel重組蛋白
  • 貨號：
    CSB-EP856705DLU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    黑腹果蠅Rel重組蛋白
  • 貨號：
    CSB-EP856705DLU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    黑腹果蠅Rel重組蛋白
  • 貨號：
    CSB-BP856705DLU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    黑腹果蠅Rel重組蛋白
  • 貨號：
    CSB-MP856705DLU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Rel; CG11992; Nuclear factor NF-kappa-B p110 subunit; Rel-p110; Relish protein) [Cleaved into: Nuclear factor NF-kappa-B p68 subunit; Rel-p68); Nuclear factor NF-kappa-B p49 subunit; Rel-p49)]
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Plays a key role in the humoral immune response. Rel-p68 subunit translocates to the nucleus where it binds to the promoter of the Cecropin A1 gene and probably other antimicrobial peptide genes. I-kappa-B kinase complex (IKKbeta and key) and PGRP-LC are essential signaling components in transmitting the lipopolysaccharide (LPS) signal leading to cact degradation for NF-kappa-B (rel) activation. Part of a Toll-related receptor pathway that functions in the apoptosis of unfit cells during cell competition. May be part of a NF-kappa-B and Tollo signaling cascade that regulates development of the peripheral nervous system. Possibly post-transcriptionally regulates the neuron-specific genes sc and ase, by promoting the rapid turnover of their transcripts in the wing imaginal disk.
  • 基因功能參考文獻：
    1. Early gene Broad complex(BR-C) could be regulating the immune pathways by activating Relish and physically interacting with it to activate antimicrobial peptides expression. PMID: 25931442
    2. The Toll/NF-kappaB signaling pathway is required for epidermal wound repair in Drosophila. PMID: 25427801
    3. Epistatic analysis indicates that DMAP1 acts in parallel or downstream of Relish. PMID: 24947515
    4. the IMD/Relish signaling pathway is a central regulator of microbiota-mediated transcriptional response PMID: 24733183
    5. Relish mutations inhibited upregulation of innate immune response genes and neurodegeneration in ATM mutants. PMID: 23502677
    6. induction of antimicrobial peptide expression is via activation of the NF-kappaB transcription factor Relish in the immune deficiency (Imd) pathway PMID: 22470576
    7. NF-kappaB transcription factor Relish mediates the alternative pathway of cell death in Drosophila PMID: 22328149
    8. Data show that inhibition of NF-kappaB with pyrrolidine dithiocarbamate increases the median lifespan (13-20%) and the age of 90% mortality (11-14%) in Drosophila melanogaster females and males, respectively. PMID: 21483034
    9. Ectopic Ras/MAPK pathway activation results in the suppression of Drosophila IMD/NF-kappaB signalling. PMID: 21297578
    10. immune response increases sleep in flies in a manner that is gated by the circadian clock and that requires the NFkappaB Relish; supports a role of sleep in a recovery process and demonstrate a conserved feature of the Drosophila model of sleep. PMID: 20144235
    11. activation is controlled by PGRP-LC PMID: 11872802
    12. Overexpression of a pattern-recognition receptor, peptidoglycan-recognition protein-LE, activates imd/relish-mediated antibacterial defense and the prophenoloxidase cascade in larvae. PMID: 12359879
    13. a caspase target site, located in the linker region between the Rel and the IkappaB-like domain, is the site of signal-dependent cleavage PMID: 12732719
    14. Rel synergy with GATA plays a pervasive role in the immune response. PMID: 14731391
    15. Rel limits duration of JNK activation in response to Gram-neg infections. Rel activation is linked to TAK1 degradation, terminating JNK signaling, resulting in a transient JNK-dependent response that precedes sustained induction of immune loci. PMID: 15037551
    16. Molecular modeling was used to compare the tertiary structure of Relish with two other Drosophila proteins. PMID: 17785540
    17. the C-terminal IkappaB-like domain executes a scaffolding and recruiting function for full activation of Relish. PMID: 19135474
    18. show that the IKK complex controls Relish by direct phosphorylation on serines 528 and 529. Surprisingly, these phosphorylation sites are not required for Relish cleavage, nuclear translocation, or DNA binding PMID: 19497884

    顯示更多

    收起更多

  • 亞細胞定位：
    [Nuclear factor NF-kappa-B p68 subunit]: Nucleus.; [Nuclear factor NF-kappa-B p110 subunit]: Cytoplasm.; [Nuclear factor NF-kappa-B p49 subunit]: Cytoplasm.
  • 數據庫鏈接：

    KEGG: dme:Dmel_CG11992

    STRING: 7227.FBpp0088375

    UniGene: Dm.4154



主站蜘蛛池模板： 国产精品成人99一区无码| 久久66热人妻偷产精品9| aⅴ亚洲 日韩 色 图网站 播放 | 色伦专区97中文字幕| 无码专区视频精品老司机| 性欧美俄罗斯乱妇| 天堂…中文在线最新版在线| 在线观看免费人成视频色9| 青草视频在线播放| 麻豆精品一卡二卡三卡| 2021国产精品国产精华| 中文在线www天堂网| 国产成人免费一区二区三区| 免费体验区试看120秒| 中文日韩亚洲欧美制服| 午夜性色福利在线观看视频| 精品无码久久久久国产电影| 亚洲の无码国产の无码步美| 国产网友自拍在线视频| 欧美毛多水多黑寡妇| 亚洲熟妇av一区二区三区浪潮| 亚洲丰满熟妇在线播放电影全集| 亚洲爆乳精品无码一区二区| 人妻丰满熟妇av无码区不卡| 99精品视频一区在线观看| 亚洲国产成人精品激情姿源 | 国产激情久久久久影院老熟女| 国产xxxx69真实实拍| 欧美日韩视频在线第一区| 波多野结衣一区二区三区av高清| 久久精品国产99久久久古代 | 美女粉嫩饱满的一线天mp4| 国产一卡二卡三卡四卡视频版| 麻豆亚洲一区| 成年免费视频黄网站在线观看| 国产亚洲精品久久久久久无| 色欲aⅴ 无码| 国产激情з∠视频一区二区| 国产精品无码一区二区桃花视频| 97超碰精品成人国产| 综合欧美亚洲日本一区|