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PITRM1

PITRM1 is a protein in humans that is encoded by PITRM1 gene. Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing. Has an ATP-independent activity. Specifically cleaves peptides in the range of 5 to 65 residues. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. Degrades the transit peptides of mitochondrial proteins after their cleavage. Also degrades other unstructured peptides. It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion. It is a highly efficient protease, at least toward amyloid-beta protein 40. Cleaves that peptide at a specific position and is probably not processive, releasing digested peptides intermediates that can be further cleaved subsequently.

PITRM1 Antibodies

PITRM1 for Homo sapiens (Human)

PITRM1 Proteins

PITRM1 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

PITRM1 Proteins for Homo sapiens (Human)

PITRM1 Proteins for Pongo abelii (Sumatran orangutan)

PITRM1 Proteins for Xenopus laevis (African clawed frog)

PITRM1 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

PITRM1 Proteins for Mus musculus (Mouse)



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