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  4. PITRM1 Antibody

PITRM1 Antibody

  • 中文名稱：
    PITRM1兔多克隆抗體
  • 貨號：
    CSB-PA692283ESR1HU
  • 規格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: PITRM1 antibody at 2µg/ml
      Lane 1: A549 whole cell lysate
      Lane 2: Mouse kidney tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 118, 107 kDa
      Observed band size: 118 kDa
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA692283ESR1HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PITRM1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    hMP1 antibody; hPreP antibody; KIAA1104 antibody; Metalloprotease 1 antibody; MGC138192 antibody; MGC141929 antibody; mitochondrial antibody; MP1 antibody; Pitrilysin metallopeptidase 1 antibody; Pitrilysin metalloproteinase 1 antibody; PITRM 1 antibody; PITRM1 antibody; PreP antibody; PreP peptidasome antibody; PREP_HUMAN antibody; Presequence protease antibody; Presequence protease mitochondrial antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human Presequence protease, mitochondrial protein (758-1037AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing. Has an ATP-independent activity. Specifically cleaves peptides in the range of 5 to 65 residues. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. Degrades the transit peptides of mitochondrial proteins after their cleavage. Also degrades other unstructured peptides. It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion. It is a highly efficient protease, at least toward amyloid-beta protein 40. Cleaves that peptide at a specific position and is probably not processive, releasing digested peptides intermediates that can be further cleaved subsequently.
  • 基因功能參考文獻：
    1. Redox control of hPreP in the mitochondrial matrix and the protective role of the conserved methionine 206 residue as an internal antioxidant. PMID: 23041349
    2. The authors identified two siblings carrying a homozygous PITRM1 missense mutation (c.548G>A, p.Arg183Gln) associated with an autosomal recessive, slowly progressive syndrome characterised by mental retardation, spinocerebellar ataxia, cognitive decline and psychosis. PMID: 26697887
    3. Data show that the hPreP presequence only targets GFP to the matrix of mammalian and yeast mitochondria. PMID: 21621546
    4. This study demonstrated decreased proteolytic activity of the mitochondrial amyloid-beta degrading enzyme, PreP peptidasome, in Alzheimer's disease brain mitochondria. PMID: 21750375
    5. our data suggest that genetic variation in the hPreP gene PITRM1 may potentially contribute to mitochondrial dysfunctions PMID: 19962426
    6. The substrate specificity of the mitochondrial metallopeptidase proteinase 1 (MP1) was investigated and its mitochondrial targeting signal identified. PMID: 19196155
    7. Data revealed that six polymorphisms of F10, PITRM1, PCSK2, JPH3, MYO7B, and AKAP12 were related (P<0.05) to the prevalence of chronic kidney disease. PMID: 19724895

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  • 亞細胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    Peptidase M16 family, PreP subfamily
  • 組織特異性：
    Widely expressed. Expressed at higher level in muscle and heart compared to brain, pancreas, liver, lung and placenta.
  • 數據庫鏈接：

    HGNC: 17663

    KEGG: hsa:10531

    STRING: 9606.ENSP00000370377

    UniGene: Hs.528300



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