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NLRP3

NLRP3,即含pyrin結(jié)構(gòu)域的NOD樣受體3,別名PYRIN-containing APAF1-like protein 1。它是一種多蛋白復(fù)合體,是固有免疫系統(tǒng)中的重要組成部分,主要在細胞質(zhì)中發(fā)揮作用。NLRP3炎性小體能夠識別各種病原體相關(guān)分子模式(PAMPs)和損傷相關(guān)分子模式(DAMPs),激活后促進半胱氨酸天冬氨酸特異性蛋白酶-1(caspase-1)的活化,進而切割前體IL-1β和IL-18成為成熟形式,引發(fā)炎癥反應(yīng)。NLRP3炎性小體的生物學(xué)意義在于其在調(diào)節(jié)宿主免疫反應(yīng)中發(fā)揮的重要作用。它不僅參與機體對病原體的防御,還涉及多種炎癥性疾病的發(fā)生發(fā)展。NLRP3炎性小體的異常激活與多種疾病相關(guān),包括膿毒癥、代謝性疾病、自身炎癥性疾病等。因此,NLRP3成為了炎癥性疾病治療的潛在靶點,針對NLRP3炎性小體的抑制劑正在被廣泛研究,以期開發(fā)出新的抗炎藥物。

熱銷產(chǎn)品

Recombinant Human NACHT, LRR and PYD domains-containing protein 3 (NLRP3), partial (CSB-EP822275HU2)

驗證數(shù)據(jù)

CSB-EP822275HU2

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

NLRP3 Antibody (CSB-PA015871LA01HU)

驗證數(shù)據(jù)

CSB-PA015871LA01HU

Immunohistochemistry of paraffin-embedded human bladder cancer using CSB-PA015871LA01HU at dilution of 1:100

CSB-PA015871LA01HU

Immunofluorescent analysis of HepG2 cells using CSB-PA015871LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Mouse NACHT, LRR and PYD domains-containing protein 3(NLRP3) ELISA kit (CSB-EL015871MO)

驗證數(shù)據(jù)

CSB-EL015871MO 標(biāo)準(zhǔn)曲線

貨號:CSB-EL015871MO

規(guī)格:96T/48T

靈敏度:1.56 pg/mL

檢測范圍:6.25 pg/mL-400 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

NLRP3 Antibodies

NLRP3 for Homo sapiens (Human)

NLRP3 for Mus musculus (Mouse)

NLRP3 Proteins

NLRP3 Proteins for Bos taurus (Bovine)

NLRP3 Proteins for Macaca mulatta (Rhesus macaque)

NLRP3 Proteins for Homo sapiens (Human)

NLRP3 Proteins for Mus musculus (Mouse)

NLRP3 ELISA Kit

NLRP3 ELISA Kit for Homo sapiens (Human)

NLRP3 ELISA Kit for Mus musculus (Mouse)