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MAGEA1

MAGEA1,即黑色素瘤相關(guān)抗原家族A1,是一種在多種腫瘤中表達(dá)的蛋白,特別是在黑色素瘤、肺癌、胃癌等惡性腫瘤中。MAGEA1屬于MAGE(melanoma-associated antigen)家族成員,通常在睪丸組織中表達(dá),而在其他正常組織中表達(dá)較低或不表達(dá)。MAGEA1的作用機(jī)制涉及調(diào)節(jié)細(xì)胞凋亡、影響腫瘤的發(fā)生發(fā)展,其在腫瘤細(xì)胞中的表達(dá)水平與腫瘤的侵襲性和預(yù)后密切相關(guān)。MAGEA1參與的信號通路包括Wnt/β-catenin信號通路,它通過激活該通路促進(jìn)黑色素瘤細(xì)胞的上皮-間充質(zhì)轉(zhuǎn)化(EMT),提高黑色素瘤細(xì)胞的侵襲與遷移能力。此外,MAGEA1還可能參與其他信號通路,如成纖維細(xì)胞生長因子受體2(FGFR2)信號通路,通過調(diào)節(jié)纖維連接蛋白控制細(xì)胞的增殖和遷移。在生物學(xué)意義上,MAGEA1的異常表達(dá)與腫瘤的增殖、侵襲、轉(zhuǎn)移等過程密切相關(guān),是腫瘤治療和免疫治療的潛在靶點。MAGEA1的高表達(dá)通常與腫瘤的不良預(yù)后相關(guān),其可作為腫瘤生物標(biāo)志物用于診斷和治療監(jiān)測。

熱銷產(chǎn)品

Recombinant Human Melanoma-associated antigen 1 (MAGEA1) (CSB-YP013323HU)

驗證數(shù)據(jù)

CSB-YP013323HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-YP013323HU

Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP013323HU could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) MAGEA1.

CSB-YP013323HU

Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP013323HU could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) MAGEA1.

MAGEA1 Antibody (CSB-PA013323ESR2HU)

驗證數(shù)據(jù)

CSB-PA013323ESR2HU

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA013323ESR2HU at dilution of 1:100

CSB-PA013323ESR2HU

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA013323ESR2HU at dilution of 1:100

CSB-PA013323ESR2HU

Immunoprecipitating MAGEA1 in Hela whole cell lysate
Lane 1: Rabbit control IgG instead of CSB-PA013323ESR2HU in Hela whole cell lysate. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
Lane 2: CSB-PA013323ESR2HU (8µg) + Hela whole cell lysate (500µg)
Lane 3: Hela whole cell lysate (10µg)

MAGEA1 Antibodies

MAGEA1 for Homo sapiens (Human)

MAGEA1 Proteins

MAGEA1 Proteins for Homo sapiens (Human)

MAGEA1 ELISA Kit

MAGEA1 ELISA Kit for Homo sapiens (Human)