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  4. Human Melanoma-associated antigen 1(MAGEA1) ELISA kit

Human Melanoma-associated antigen 1(MAGEA1) ELISA kit

  • 中文名稱：
    人黑色素瘤相關抗原1(MAGEA1)酶聯免疫試劑盒
  • 貨號：
    CSB-EL013323HU
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    人黑色素瘤相關抗原1(MAGEA1)酶聯免疫試劑盒（CSB-EL013323HU）為雙抗夾心法ELISA試劑盒，定量檢測組織勻漿、細胞裂解物樣本中的MAGEA1含量。MAGEA1屬于黑色素瘤抗原基因（MAGE）家族，正常情況下僅在睪丸和胎盤表達，腫瘤發生時可異常激活。其研究機制方面，它能作為腫瘤相關抗原被機體免疫系統識別，是腫瘤免疫治療潛在靶點，有望通過激活免疫應答來殺傷腫瘤細胞。試劑盒檢測范圍為0.156 ng/ml-10ng/ml，適用于體外培養的腫瘤細胞模型中MAGEA1表達動態監測、腫瘤組織樣本的蛋白定量分析以及靶向藥物作用機制研究。為探索腫瘤生物標志物功能、驗證治療靶點及篩選抗癌化合物提供可靠的實驗工具，廣泛應用于腫瘤免疫學、分子病理學等基礎科研領域。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    Antigen MZ2 E ELISA Kit; Antigen MZ2-E ELISA Kit; Cancer/testis antigen 1.1 ELISA Kit; cancer/testis antigen family 1, member 1 ELISA Kit; CT1.1 ELISA Kit; MAGA1_HUMAN ELISA Kit; MAGE 1 antigen ELISA Kit; MAGE-1 antigen ELISA Kit; MAGE1 ELISA Kit; MAGE1A ELISA Kit; MAGEA1 ELISA Kit; Melanoma antigen 1 ELISA Kit; Melanoma antigen family A 1 (directs expression of antigen MZ2 E) ELISA Kit; Melanoma antigen family A 1 ELISA Kit; Melanoma antigen MAGE 1 ELISA Kit; Melanoma associated antigen 1 ELISA Kit; Melanoma associated antigen MZ2 E ELISA Kit; Melanoma-associated antigen 1 ELISA Kit; MGC9326 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    tissue homogenates, cell lysates
  • 檢測范圍：
    0.156 ng/ml-10ng/ml
  • 靈敏度：
    0.039 ng/ml
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Cancer
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 線性度：
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
  • 基因功能參考文獻：
    1. The expression of MAGE-A genes in peripheral blood may act as a poor prognostic marker in patients with lung cancer. PMID: 29430849
    2. MAGE-A expression in blood or bone marrow at tumor surgery is an independent predictor of survival in resected non-small cell lung cancer PMID: 27542766
    3. Authors revealed a novel interaction between MAGEA1 and the intracellular segment of NOTCH1 receptor (NICD1). MAGEA1 reduced NICD1's stability by promoting the ubiquitin modification of NICD1. PMID: 28459460
    4. In patients with Colon cancer, the expression of MAGE-A(1-6) gene was associated with a poor prognosis. PMID: 28631709
    5. MAGEA1 was expression in 15% of synovial sarcomas and was not associated with prognosis. PMID: 27993576
    6. Data show that overall survival (OS) was significantly lower for patients expressing pan-MAGE or MAGE-A1/A3/A4 in both independent cohorts. PMID: 28146422
    7. These data demonstrate that MAGE-A1-, MAGE-A3-, and NY-ESO-1-specific T cells with antigen-specific cytotoxicity can be cultured from healthy donors and patient-derived cells making adoptive immunotherapy with these cytotoxic T lymphocyte feasible. PMID: 28677424
    8. up-regulation of MAGE-A1 dramatically promoted proliferation, migration, and invasion of human melanoma cell lines in vitro PMID: 27045082
    9. The overall survival of laryngeal squamous cell carcinoma patients with positive MAGE-A1, MAGE-A9, or MAGE-A11 expression was lower than the patients without MAGE-A1, MAGE-A9, or MAGE-A11 expression. PMID: 26766421
    10. MAGE-A is more highly expressed than NY-ESO-1 in a majority of human malignancies PMID: 27070449
    11. TRIM31 directly binds to NSE4, suggesting the existence of a TRIM31-MAGEA1-NSE4 complex reminiscent of the NSE1-NSE3-NSE4 trimer. PMID: 25590999
    12. Differential regulation of MAGE-A1 promoter activity by BORIS and Sp1, both interacting with the TATA binding protein. PMID: 25363021
    13. DNA methylation has a dominant role in the epigenetic hierarchy governing MAGEA1 expression PMID: 23472218
    14. results show the absence and/or low expression of MAGE A1 transcripts in oral squamous cell carcinoma; presence of hypomethylation at a small level at the promoter site of MAGE A1 was detected in both oral squamous cell carcinoma and normal oral mucosa PMID: 22447174
    15. Report MAGEA1-A6 expression in sputum suggests presence of lung cancer cells or precancerous cells. PMID: 22134685
    16. High MAGE-1 is associated with differentiated advanced gastric cancer. PMID: 21042944
    17. MAGE1 expression mediated by demethylation of MAGE1 promoter induce progression of non-small cell lung cancer. PMID: 21273595
    18. CCL3 and CCL20-recruited dendritic cells modified by melanoma antigen gene-1 have a role in anti-tumor immunity against gastric cancer PMID: 20420712
    19. Tumor-specific antigen MAGE may play a role in the occurrence and development of ovarian cancerc and can be used as one of the important indicators for early diagnosis, efficacy evaluation and prognostic determination of ovarian cancer. PMID: 20423514
    20. MAGE-A peptides and HLA class I molecules are expressed in hepatocellular carcinoma PMID: 20592351
    21. The high expression rates of MAGE-1 and MAGE-3 genes in IHCC suggests the MAGE-1 and MAGE-3 gene may be a target for immunotherapy in IHCC patients. PMID: 18505125
    22. Since 37% of patients with operable NSCLC harbored disseminated tumor cells that expressed MAGE-A, only these patients might benefit from adjuvant immunotherapies directed against MAGE-A1 to -A6. PMID: 19467731
    23. The MAGE-A1 gene expression is not determined solely by methylation status of the promoter region in hematological malignancies. PMID: 12443884
    24. Spontaneous in vivo priming of MAGE-specific T cell response and high frequency of MAGE1 and MAGE3 expression in hepatocellular carcinoma makes this antigen potential candidate for MAGE-specific immunotherapy in hepatocellular carcinoma. PMID: 14672620
    25. MAGE-A1 can function as a potent transcriptional repressor via interactions with Ski Interacting Protein and the deacetylase HDAC1. PMID: 15316101
    26. a novel sequence-specific DNA-protein interaction at the -30 CpG dinucleotide upstream of the gene was found having a vital part to play in the DNA methylation mediated transcription silencing of the MAGE-A1 gene PMID: 15353125
    27. Present, by immunocytochemistry, in normal prostate, prostatic hypertrophy and prostate cancer. PMID: 16114059
    28. down-regulation of DNMT1 methyltransferase leads to activation and stable hypomethylation of MAGE-A1 in melanoma cells PMID: 16497664
    29. Detection of aberrant methylation patterns of MAGEs CpG islands using Methylation-special PCR may be useful for diagnosis of Hepatocellular Carcinoma. PMID: 16516880
    30. The promoter hypomethylation of MAGE-A1 and MAGE-A3 genes up-regulates its expression in colorectal carcinomas as well as in gastric cancers and might play a significant role in the development and progression of human colorectal carcinomas. PMID: 17007017
    31. MAGE-A1 and NY-ESO-1 are associated with highly proliferating germ cells, whereas GAGE proteins have a more general function in germ cells unrelated to any specific developmental stage PMID: 17208940
    32. Results suggest that although MAGE-A1 does not participate directly in the drug-resistant phenotype, the expression of MAGE-A1 could be a marker for the prediction of resistance to taxan-based chemotherapies in patients with gastric cancers. PMID: 17611652
    33. These data show, for the first time, the involvement of methyl-CpG binding domain proteins in the regulation of the MAGE-A genes. PMID: 17634428
    34. Report genetic alterations of MAGE A1 in Korean colorectal cancer patients. PMID: 17704924
    35. demethylation of MAGE-A1 by Mouse embryonic stem cells PMID: 18094622
    36. Multiple simultaneous detection of MAGE-A [subtypes] more specific and sensitive than detection of single MAGE-A antigen for the diagnostic and prognostic evaluation of oral squamous cell carcinoma PMID: 18197853
    37. The protective effect of the expression of the MAGE-A1 gene against tumoral progression of neuroblastoma is confirmed. PMID: 18820946
    38. Treatment of A2780/cp70 with decitabine and belinostat results in a marked increase in expression of epigenetically silenced MLH1 and MAGE-A1 both in vitro and in vivo when compared with decitabine alone. PMID: 19259094

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  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 組織特異性：
    Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes. Never expressed in kidney tumors, leukemias and lymphomas.
  • 數據庫鏈接：

    HGNC: 6796

    OMIM: 300016

    KEGG: hsa:4100

    STRING: 9606.ENSP00000349085

    UniGene: Hs.72879



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