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MAD2L2

Mitotic spindle assembly checkpoint protein MAD2B is a protein in humans that is encoded by MAD2L2 gene. Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation.

MAD2L2 Antibodies

MAD2L2 for Homo sapiens (Human)

MAD2L2 Proteins

MAD2L2 Proteins for Rattus norvegicus (Rat)

MAD2L2 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

MAD2L2 Proteins for Bos taurus (Bovine)

MAD2L2 Proteins for Gallus gallus (Chicken)

MAD2L2 Proteins for Dictyostelium discoideum (Slime mold)

MAD2L2 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

MAD2L2 Proteins for Xenopus laevis (African clawed frog)

MAD2L2 Proteins for Mus musculus (Mouse)

MAD2L2 Proteins for Homo sapiens (Human)



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