在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MAD2L2 Antibody, Biotin conjugated

  • 中文名稱:
    MAD2L2兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA887064LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) MAD2L2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Homolog of REV7 S cerevisiae antibody; hREV7 antibody; MAD2 (mitotic arrest deficient yeast, homolog) like 2 antibody; MAD2 homolog antibody; MAD2 like 2 antibody; MAD2 mitotic arrest deficient like 2 antibody; MAD2-like protein 2 antibody; MAD2B antibody; Mad2l2 antibody; MD2L2_HUMAN antibody; Mitotic Arrest Deficient 2 L2 antibody; Mitotic arrest deficient 2-like protein 2 antibody; Mitotic arrest deficient homolog like 2 antibody; Mitotic arrest deficient like 2 (yeast) antibody; Mitotic arrest deficient yeast homolog antibody; Mitotic spindle assembly checkpoint protein MAD2B antibody; Polymerase (DNA directed) zeta 2 accessory subunit antibody; POLZ2 antibody; REV 7 antibody; REV7 antibody; REV7 homolog antibody; Weakly similar to Mitotic MAD2 protein (S cerevisiae) antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Mitotic spindle assembly checkpoint protein MAD2B protein (1-211AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation.
  • 基因功能參考文獻:
    1. results provide insights into the structure of the Rev1/Polzeta TLS assembly and highlight the function of Rev7 homo- and heterodimerization. PMID: 30111544
    2. Skp2, a confirmed APC/C-CDH1 substrate and E-cadherin destroyer, was increased in TGF-beta1-treated proximal tubular epithelial cells, which could be blocked by MAD2B depletion. PMID: 27488450
    3. structure-based interaction analyses revealed an unprecedented mechanism involving CAMP's WK motif. Surprisingly, in one of the crystal forms, the MAD2L2-CAMP complex formed a dimeric structure in which the C-terminal region of MAD2L2 was swapped and adopted an immature structure PMID: 28887307
    4. REV7 is a previously undescribed FA gene, which we term FANCV PMID: 27500492
    5. Knockdown of REV7 inhibited the migration, invasion, and epithelial-mesenchymal transition (EMT) of breast cancer cells. Meanwhile, overexpression of REV7 promoted the migration, invasion, and EMT of breast cancer cells. PMID: 27712588
    6. hMAD2 also binds to the hREV7-binding sequence in hREV3, whereas hMAD2 does not bind to a similar sequence in ADAM9 or ELK-1 and hREV7 does not bind to the hMAD2-binding sequence in hMAD1 or hCDC20. PMID: 20088965
    7. data establish MAD2L2 as a crucial contributor to the control of DNA repair activity by 53BP1 that promotes NHEJ by inhibiting 5' end resection downstream of RIF1 PMID: 25799990
    8. results reveal an unexpected crucial function of REV7 downstream of 53BP1 in coordinating pathological DSB repair pathway choices in BRCA1-deficient cells PMID: 25799992
    9. that MAD2B may play an important role in high glucose-mediated podocyte injury of diabetic nephropathy via modulation of Cdh1, cyclin B1, and Skp2 expression PMID: 25651564
    10. Rev7 is essential for mutagenesis and S phase progression in UV-irradiated fibroblasts. PMID: 18295554
    11. These findings indicate that depletion of REV7 enhances sensitivity to cisplatin treatment in ovarian clear cell carcinoma (CCC), suggesting that REV7 is a candidate molecular target in CCC management. PMID: 24597627
    12. MAD2L2 helps to ensure a robustly bistable switch between APC/C(CDC20) and APC/C(CDH1) during the metaphase-to-anaphase transition, thereby contributing to mitotic fidelity. PMID: 24100295
    13. REV7 is required for anaphase-promoting complex-dependent ubiquitination and degradation of translesion DNA polymerase REV1. PMID: 23287467
    14. MAD2B may mediate Sim2 function during development in CNS and thereby play a critical role in pathophysiological mechanisms in Down syndrome PMID: 22660985
    15. analysis of the crystal structure of the ternary complex composed of the C-terminal domain of human REV1, REV7, and a REV3 fragment PMID: 22859296
    16. the Rev1 C-terminal domain utilizes independent interaction interfaces to simultaneously bind a fragment of the 'inserter' poleta and Rev7 subunit of the 'extender' polvarsigma, thereby serving as a cassette that may accommodate several polymerases PMID: 22828282
    17. ternary complex of the C-terminal domain of human REV1 in complex with REV7 bound to a REV3 fragment has been crystallized. The crystals belonged to space group P3(1)21, with unit-cell parameters a = b = 74.7, c = 124.5 A PMID: 22869133
    18. The REV1/Polzeta complex maintains genomic stability by directly participating in DNA double-stranded break repair. PMID: 21926160
    19. Data show that MAD2B interacts with CLTA during the G2/M phase of the cell cycle and that depletion of MAD2B leads to a marked increase in the percentage of misaligned chromosomes and a redistribution of CLTA during mitosis. PMID: 21152103
    20. The hRev7 is required for TLS past BPDE-induced DNA lesions but that it is not essential for inserting nucleotides opposite such lesions suggest a role for hPolzeta in the extension step of translesion synthesis. PMID: 21143968
    21. show the first crystal structure of REV7 in complex with a fragment of REV3 polymerase (residues 1847-1898) and reveal the mechanism underlying REV7-REV3 interaction PMID: 20164194
    22. To clarify the structural basis of the interaction between REV7 and REV3, REV7 was crystallized in complex with a REV3 fragment. PMID: 20054135
    23. the small GTPase RAN is a novel MAD2B binding protein PMID: 19753112
    24. purified human REV1 and REV7 proteins form a heterodimer in solution, which is stable through intensive purification steps. PMID: 12529368
    25. Upregulated MAD2L2 expression is associated with colorectal tumors PMID: 17044027
    26. Human Rev7 (hRev7)/MAD2B/MAD2L2 is an interaction partner for Elk-1 and hRev7 acts to promote Elk-1 phosphorylation by the c-Jun N-terminal protein kinase (JNK) MAP kinases. PMID: 17296730
    27. Chromophobe renal cell carcinoma presented underexpression of MAD1, and MAD2L2. PMID: 17333263
    28. Hepatocellular carcinoma-associated gene 2 interacts with MAD2L2. PMID: 17541814
    29. Study provides the first evidence for the involvement of MAD2B in TCF4-mediated epithelial-mesenchymal transdifferentiation. PMID: 19443654

    顯示更多

    收起更多

  • 相關疾病:
    Fanconi anemia, complementation group V (FANCV)
  • 亞細胞定位:
    Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Chromosome.
  • 組織特異性:
    Ubiquitously expressed.
  • 數據庫鏈接:

    HGNC: 6764

    OMIM: 604094

    KEGG: hsa:10459

    STRING: 9606.ENSP00000235310

    UniGene: Hs.19400



主站蜘蛛池模板: 亚洲午夜精品久久久久久人妖| 成年轻人电影免费无码| 国产免费mv大全视频网站| 欧美变态另类牲交| 一区二区三区在线 | 日本| 国产精品久久久久久亚洲毛片| 欧美人与动性xxxxx杂| 丰满少妇高潮惨叫久久久一| 亚洲成av人片天堂网久久| 亚洲色大成影网站www永久| 中文字幕人妻熟女人妻| 免费无码不卡视频在线观看 | 国内精品久久久久影院蜜芽| 成人乱码一区二区三区四区| 99久久99久久精品免费看蜜桃| 99蜜桃在线观看免费视频网站| 动漫av纯肉无码av电影网| 18禁免费吃奶摸下激烈视频| 国产又黄又硬又粗| 香蕉在线精品视频在线| 无码专区手机在线播放| 亚洲成a人无码| 中年熟妇的大黑p| 亚洲中文字幕永久在线不卡| 青青草在在观免费福利线观看| 99精品国产成人一区二区| 大肉大捧一进一出好爽app| 国产在线不卡人成视频| 亚洲伊人成综合网| 日韩人妻一区二区三区免费| 国产免费人成视频尤勿视频| 亚洲人成小说网站色在线观看| 亚洲欭美日韩颜射在线二| 欧美野外疯狂做受xxxx高潮| 中文字幕丰满伦子无码| 少妇精品视频无码专区| 欧美一进一出抽搐大尺度视频| 三上悠亚的av片在线无码| 再深点灬舒服灬太大了在线视频| 亚洲精品中文字幕乱码三区| 无码av免费毛片一区二区|