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LGALS3BP

LGALS3BP編碼的蛋白全稱為半乳糖凝集素-3結合蛋白(Galectin-3 binding protein),常被簡稱為MAC-2BP或90K蛋白,在UniProt數據庫中也被標注為Lectin galactoside-binding soluble 3 binding protein。該蛋白是一種分泌型糖蛋白,廣泛參與細胞間相互作用與免疫調節,通過與半乳糖凝集素家族成員(如Galectin-3)結合,介導細胞黏附、炎癥反應及腫瘤微環境調控。研究發現其在多種癌癥中異常高表達,包括乳腺癌、肺癌和肝癌,可能與腫瘤轉移、血管生成及免疫逃逸相關。此外,該蛋白在病毒感染中發揮雙重作用,既能通過增強干擾素應答抑制HIV復制,又能作為HCV病毒顆粒的附著因子促進感染。在自身免疫性疾病如系統性紅斑狼瘡患者血清中,其水平顯著升高。近年來,針對LGALS3BP的藥物開發聚焦于癌癥治療領域,已有單克隆抗體藥物進入臨床前研究,試圖通過阻斷其與Galectin-3的相互作用抑制腫瘤進展。同時,其作為生物標志物的潛力也在液體活檢技術中受到關注,特別是在肝癌早期診斷和預后評估方面顯示出應用價值。

熱銷產品

Recombinant Human Galectin-3-binding protein (LGALS3BP) (CSB-EP012888HU)

驗證數據

CSB-EP012888HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

LGALS3BP Antibody (CSB-PA594413)

驗證數據

CSB-PA594413

The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA594413(LGALS3BP Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)

CSB-PA594413

The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA594413(LGALS3BP Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)

Human Galectin-3-binding protein(LGALS3BP) ELISA kit (CSB-EL012888HU)

驗證數據

CSB-EL012888HU 標準曲線

貨號:CSB-EL012888HU

規格:96T/48T

靈敏度:0.39 ng/mL

檢測范圍:1.56 ng/mL-100 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

LGALS3BP Antibodies

LGALS3BP for Homo sapiens (Human)

LGALS3BP Proteins

LGALS3BP Proteins for Homo sapiens (Human)

LGALS3BP ELISA Kit

LGALS3BP ELISA Kit for Homo sapiens (Human)