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  4. Human Galectin-3-binding protein(LGALS3BP) ELISA kit

Human Galectin-3-binding protein(LGALS3BP) ELISA kit

  • 中文名稱：
    人乳糖凝集素3結合蛋白(LGALS3BP)酶聯免疫試劑盒
  • 貨號：
    CSB-EL012888HU
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    人乳糖凝集素3結合蛋白(LGALS3BP)酶聯免疫試劑盒（CSB-EL012888HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的LGALS3BP含量。LGALS3BP 是當前受關注的靶點。它在多種生理與病理過程中發揮作用。研究聚焦其在腫瘤等疾病中的機制，如參與腫瘤細胞黏附、轉移等。對它的深入研究，有望為相關疾病的診斷、治療提供新思路和靶點。試劑盒檢測范圍為1.56 ng/mL-100 ng/mL，支持科研人員探究LGALS3BP在腫瘤生物學機制、炎癥相關疾病模型或病原體宿主相互作用中的表達規律；可用于藥物干預實驗中生物標志物的動態監測；為生命科學基礎研究提供可靠的定量分析工具。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    90K ELISA Kit; 90K MAC 2 BP ELISA Kit; Basement membrane autoantigen p105 ELISA Kit; BTBD17B ELISA Kit; Galectin 3 binding protein ELISA Kit; Galectin-3-binding protein ELISA Kit; L3 antigen ELISA Kit; Lectin galactoside binding soluble 3 binding protein ELISA Kit; Lectin galactoside-binding soluble 3-binding protein ELISA Kit; LG3BP_HUMAN ELISA Kit; LGALS3BP ELISA Kit; M2BP ELISA Kit; Mac 2 binding protein ELISA Kit; Mac 2 BP ELISA Kit; Mac-2 BP ELISA Kit; Mac-2-binding protein ELISA Kit; Mac2 BP ELISA Kit; MAC2BP ELISA Kit; Serum protein 90K ELISA Kit; TANGO10B ELISA Kit; Transport and golgi organization 10 homolog B ELISA Kit; Tumor associated antigen 90K ELISA Kit; Tumor-associated antigen 90K ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    1.56 ng/mL-100 ng/mL
  • 靈敏度：
    0.39 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Cell Biology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%      
    Three samples of known concentration were tested twenty times on one plate to assess.  
    Inter-assay Precision (Precision between assays): CV%<10%      
    Three samples of known concentration were tested in twenty assays to assess.    
                 
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human LGALS3BP in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:20Average %91
    Range %84-98
    1:40Average %90
    Range %85-95
    1:60Average %97
    Range %92-102
    1:160Average %102
    Range %96-108
  • 回收率：
    The recovery of human LGALS3BP spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range  
    Serum (n=5) 100 95-106  
    EDTA plasma (n=4) 90 85-95  
                 
                 
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average Corrected  
    100 2.620 2.645 2.633 2.541  
    50 2.265 2.366 2.316 2.224  
    25 1.628 1.673 1.651 1.559  
    12.5 0.921 0.855 0.888 0.796  
    6.25 0.571 0.589 0.580 0.488  
    3.12 0.333 0.355 0.344 0.252  
    1.56 0.190 0.188 0.189 0.097  
    0 0.093 0.090 0.092 　  
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.
  • 基因功能參考文獻：
    1. Serum M2BP might contribute to the inflammatory process in systemic lupus erythematosus. PMID: 29233037
    2. M2BP inhibits both HIV-1 Env processing and virion production.M2BP traps HIV-1 Gag to vimentin filaments to inhibit the transportation of HIV-1 Gag to the plasma membrane. PMID: 27604950
    3. Results showed that 90K destabilizes E-cadherin and affects cell adhesion and invasion in subconfluent cancer cells via dissociation of the E-cadherin-p120-catenin complex, suggesting that 90K drives less confluent tumor cells into the early steps of cancer metastasis. PMID: 29207493
    4. Low LGALS3BP expression is associated with HIV infections. PMID: 29743357
    5. Data suggest that serum levels of RBP4 and LGAL3BP are up-regulated after menopause when complicated by NAFLD (non-alcoholic fatty liver disease); RBP4 and LGAL3BP may serve as biomarkers of NAFLD in postmenopausal women. (RBP4 = retinol binding protein 4; LGAL3BP = galectin-3 binding protein) PMID: 29679552
    6. Elevated plasma M2BP levels might be predictive of unstable plaque and were associated independently with poor cardiovascular outcomes in patients with acute coronary syndromes. PMID: 28731888
    7. Serum Mac-2-binding protein expression predicts disease severity in chronic hepatitis C patients. PMID: 28811008
    8. A higher pre-treatment WFA+-M2BP level was associated with an increased risk of HCC development in patients with undetectable HBV DNA under NA therapy. PMID: 28537900
    9. the combination of 17-AAG and PI3K/Akt inhibitor would effectively suppress acquired resistance to 17-AAG. In conclusion, targeting of LGALS3BP-mediated-specific survival signaling pathway in resistant cells may provide a novel therapeutic model for the cancer therapy. PMID: 28336809
    10. serum M2BP may reflect silent atherosclerosis in apparently healthy subjects PMID: 27344370
    11. the serum M2BP-adiponectin complex is elevated in men with coronary artery disease PMID: 27588936
    12. WFA + -M2BP from hepatic stellate cells induces Mac-2 expression in Kupffer cells, which in turn activates hepatic stellate cells to be fi brogenic. PMID: 28008658
    13. The Mac-2BP may have a role in regulating the extracellular spreading and storage of the Wnts, thereby modulating their bioavailability and stability. PMID: 28756229
    14. Our present results highlight the action of 90K on promoting degradation of mutant beta-catenin lacking the phosphorylation sites in the N-terminus. PMID: 27668402
    15. Serum M2BP can be a useful biomarker for the diagnosis of pancreatic ductal adenocarcinoma and the prediction of disease progression since it potentially reflects altered pro-oncologic glycosylation enzymes PMID: 27665173
    16. In this study, we addressed this question by analysing sLex expression together with two glycoproteins (BST-2 and LGALS3BP).Concomitant high expression of BST-2 with sLex defined a sub-group of patients with ER-negative tumours displaying higher risks of liver and brain metastasis and a 3-fold decreased survival rate PMID: 27176937
    17. Results showed that in acute febrile phase, galectin-9 and galectin-3BP were induced in dengue patients compared to healthy controls suggesting that both molecules might be important inflammatory mediators in acute dengue virus infection. PMID: 27240351
    18. 90K/Mac-2BP correlated with the size of colorectal cancer. PMID: 26448934
    19. Results provide direct evidence for the involvement of CALU and LGALS3BP as potential negative regulators in the virus-triggered induction of the typeI interferons. PMID: 26124285
    20. These results provide evidence that low expression of LGALS3BP participates in malignant progression of colorectal cancer. PMID: 26219351
    21. Post-Tx WFA+-M2BP (> 2.0 COI) is associated with the risk for development of HCC among patients with SVR. The WFA+-M2BP values could be a new predictor for HCC after SVR. PMID: 26070204
    22. Serum Mac-2 binding protein levels as a novel diagnostic biomarker for prediction of disease severity and nonalcoholic steatohepatitis PMID: 23775887
    23. findings may help clarify the molecular mechanism of the tumor-suppressive effect through down-regulation of LGALS3BP by miR-596 in Oral Squamous Cell Carcinoma PMID: 26502662
    24. Studied levels of galectin-3 binding protein in milk from 247 HIV-infected Zambian mothers. Levels were higher in those mothers who transmitted HIV through breast-feeding. PMID: 23899964
    25. LGALS3BP-mediated integrin activation results into signal transmission via Akt, JNK and the Ras cascade via the Raf-ERK axis while p38 activity is kept at baseline levels PMID: 24362527
    26. Gal-3BP levels in patients with haemorrhagic fever with renal syndrome correlated with increased complement activation and with clinical variables reflecting the severity of acute hantavirus infection. PMID: 25013204
    27. These findings suggest a novel immunoinhibitory function for LGALS3BP that might be important for immune evasion of tumor cells during cancer progression. PMID: 25320078
    28. Thus, 90K constitutes a novel antiviral factor that reduces the particle infectivity of HIV-1, involving interference with the maturation and incorporation of HIV-1 Env molecules into virions. PMID: 24156545
    29. LGALS3BP is enriched in human ovarian carcinoma exosomes. PMID: 24302979
    30. Recombinant 90K showed an apparent molecular weight of approximately 78kDa which was much smaller than that ( approximately 97kDa) of the natural 90K. It is suggested that recombinant 90K has small N-glycans with about half the molecular weight of N-glycans of natural 90K. PMID: 23830458
    31. The expression of serum Mac-2 binding protein is a potential therapeutic target and biomarker for lung cancer. PMID: 23184915
    32. LGALS3BP suppresses assembly of centriolar substructures. PMID: 23443559
    33. LGALS3BP induces vascular endothelial growth factor in human breast cancer cells and promotes angiogenesis. PMID: 22864925
    34. MIR596 is frequently observed in oral squamous cell carcinoma and regulates expression of LGAL3BP. PMID: 23233740
    35. breast cancer cells express Mac-2BP as a novel E-selectin ligand, potentially revealing a new prognostic and therapeutic target for breast cancer PMID: 22970241
    36. Single nucleotide polymorphism (SNP) of LGALS3BP gene (found in NCBI) database are not characteristic for papillary thyroid cancer, follicular adenomas and nodular goiter PMID: 17091456
    37. results show that NF-kappaB regulated the expression of G3BP and that G3BP increased the adhesion of T47D breast cancer cells to fibronectin PMID: 22447108
    38. Adeno-associated virus type 6 interacts with G3BP in human and dog sera but not in macaque serum. PMID: 22496229
    39. There is no difference in Gal-3 expression in peripheral blood lymphocytes in patients with papillary thyroid cancer PMID: 17091455
    40. LGALS3BP gene was expressed by neuroblatoma cell lines and patients' neuroblasts PMID: 21660451
    41. serum changes of three glycoproteins, galectin-3 binding protein, insulin-like growth factor binding protein 3, and thrombospondin 1, was associated with the development of hepatocellular carcinoma PMID: 21474793
    42. Mac-2BP was detected as a predominant DC-SIGN ligand expressed on some primary colorectal cancer tissues PMID: 21515679
    43. These results suggest that galectin-3 binding protein may be a potential therapeutic target for treatment of, at least, colon cancer patients with high expression of galectin-3 binding protein. PMID: 21094132
    44. Serum Mac-2BP does not appear to originate in the prostate and it is unlikely that Mac-2BP can be used for the differential diagnosis of prostate cancer versus benign prostatic hyperplasia. PMID: 20583127
    45. Initial assessment showed that serum Mac-2BP is significantly elevated in patients with NET (neuroendocrine tumors) and is expressed by the majority of NET tissues. PMID: 20019050
    46. structural and functional properties of M2BP PMID: 11867635
    47. Expression of 90K (Mac-2 BP) correlates with distant metastasis and predicts survival in stage I non-small cell lung cancer patients. PMID: 11980646
    48. REVIEW: role in tumor progression and metastasis PMID: 14758079
    49. 90K plays an important role in the maintenance of an appropriate level of immune response. PMID: 15231701
    50. Elevated Mac-2 binding protein is associated with distant metastasis and higher tumor stage in gastric cancer PMID: 17131321

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  • 亞細胞定位：
    Secreted. Secreted, extracellular space, extracellular matrix.
  • 組織特異性：
    Ubiquitous. Detected in body fluids such as semen, milk, serum, tears, saliva and urine. Expressed by keratinocytes and fibroblasts.
  • 數據庫鏈接：

    HGNC: 6564

    OMIM: 600626

    KEGG: hsa:3959

    STRING: 9606.ENSP00000262776

    UniGene: Hs.514535



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