LBR
LBR,全名為lamin B受體,也被稱為核纖層蛋白B受體。它在細胞核膜的內層,負責將核纖層和異染色質錨定在核膜上,對染色質和核纖層蛋白B之間的相互作用至關重要。LBR蛋白在膽固醇合成過程中也扮演著關鍵角色。LBR基因的突變與遺傳性骨骼發育不良和Greenberg骨骼發育不良等疾病相關。目前,針對LBR蛋白的藥物研發主要集中在開發抗體和siRNA等治療方法,以治療相關疾病。
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驗證數據

The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA070468(LBR Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)

Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal brain tissue, Primary antibody: CSB-PA070468(LBR Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes
LBR Antibodies
LBR for Homo sapiens (Human)
產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
---|---|---|---|
CSB-PA012776GA01HU | LBR Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA070468 | LBR Antibody | Human | ELISA,WB,IHC |
LBR Proteins
LBR Proteins for Homo sapiens (Human)
產品貨號 | 產品名稱 | 來源 |
---|---|---|
CSB-YP613520HU CSB-EP613520HU CSB-BP613520HU CSB-MP613520HU CSB-EP613520HU-B |
Recombinant Human Delta(14)-sterol reductase LBR (LBR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |