在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

LBR Antibody

  • 中文名稱:
    LBR兔多克隆抗體
  • 貨號:
    CSB-PA012776GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    DHCR 14B antibody; DHCR14B antibody; Integral nuclear envelope inner membrane protein antibody; Lamin-B receptor antibody; LBR antibody; LBR_HUMAN antibody; LMN 2R antibody; LMN2R antibody; MGC9041 antibody; PHA antibody; PRO0650 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human LBR
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis. Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation. Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation. Anchors the lamina and the heterochromatin to the inner nuclear membrane.
  • 基因功能參考文獻:
    1. The authors demonstrate that human LBR is essential for cholesterol synthesis. PMID: 27336722
    2. These observations point to a new mechanism regulating the localization of LBR, which is governed by an ELYS-mediated phosphorylation network. PMID: 27802161
    3. The primary response of cells to various stresses leading to senescence consists of the down-regulation of LBR and LB1 to attain reversal of the chromatin architecture. PMID: 27760841
    4. We have shown here that lamin B receptor (LBR) showed a change in localization in both BrdU-induced and replicative senescent cells. PMID: 27059139
    5. Data indicate that proto-oncogene protein c-akt (Akt) phosphorylates distinct sites than SRPK1 protein within the arginine-serine (RS) domain of Lamin B Receptor (LBR). PMID: 27105349
    6. Lamin B receptor mRNA expression was directly associated with tumor grade in breast cancer patients(grade 1 vs. grade 3 - 0.00 vs. 0.00; p = 0.0479) and Nottingham Prognostic Index (NPI1 vs. NPI3 - 0.00 vs. 0.00; p = 0.0551). PMID: 24293108
    7. Mutation in LBR gene is associated with pelger-huet anomaly and a mild skeletal phenotype. PMID: 23824842
    8. Lymphohematopoietic licence: sterol C-14 reductase activity of lamin B receptor (Lbr) is essential for neutrophil differentiation. PMID: 22581323
    9. LBR missense mutations can abolish sterol reductase activity, causing lethal Greenberg dysplasia but not Pelger anomaly PMID: 21327084
    10. The LBR knockdown cells retain an ovoid shaped nucleus with reduced levels of lamin A/C during in vitro granulopoiesis induced with retinoic acid. PMID: 21327094
    11. Our studies reveal for the first time a mechanism that controls the timing of nuclear envelope reassembly through modification of the integral nuclear membrane protein lamin B receptor PMID: 21795390
    12. a highly significant gene-dosage effect between the gene copy number and the nuclear segmentation index of neutrophils PMID: 21326950
    13. LBR is heavily expressed in papillary thyroid carcinoma cells, but an abnormal folding of the protein might explain its lack of immunohistochemical reactivity and be associated with the anomalous folding of the nuclear membrane. PMID: 21103616
    14. LBR targets the membrane precursor vesicles to chromatin by interacting with importin beta in a LBR phosphorylation-dependent manner during the NE assembly at the end of mitosis PMID: 20576617
    15. LBR mutant variants and sterol reductases can severely interfere with the regular organization of the nuclear envelope and the endoplasmic reticulum. PMID: 19940018
    16. results suggest that LMNA, ZMPSTE24, and LBR sequence variations are not major genetic determinants involved in scleroderma pathogenesis PMID: 19645629
    17. The binding of lamin B receptor to chromatin is regulated by phosphorylation in the arginine-serine repeat-containing REGION PMID: 11846796
    18. Mutations in the gene encoding the lamin B receptor produce an altered nuclear morphology in granulocytes (Pelger-Huet anomaly). PMID: 12118250
    19. Autosomal recessive HEM/Greenberg skeletal dysplasia is caused by 3 beta-hydroxysterol delta 14-reductase deficiency due to mutations in this gene. PMID: 12618959
    20. examination of temporal association with protamine 1 during spermiogenesis PMID: 14701833
    21. SR protein kinase and cdc2 kinase regulate lamin B receptor binding to chromatin PMID: 14718546
    22. MeCP2 interacts in vitro and in vivo with the inner nuclear membrane protein LBR, and the unstructured aminoacidic sequence linking the MBD and TRD domains of MeCP2 is responsible for this association. PMID: 19331822

    顯示更多

    收起更多

  • 相關疾病:
    Pelger-Huet anomaly (PHA); Greenberg dysplasia (GRBGD); Reynolds syndrome (REYNS)
  • 亞細胞定位:
    Nucleus inner membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. Cytoplasm. Nucleus.
  • 蛋白家族:
    ERG4/ERG24 family
  • 組織特異性:
    Expressed in the bone marrow, liver, heart, adrenal gland, lung, placenta and uterus. Expressed in osteoclasts and osteoblast-like cells.
  • 數據庫鏈接:

    HGNC: 6518

    OMIM: 169400

    KEGG: hsa:3930

    STRING: 9606.ENSP00000272163

    UniGene: Hs.435166



主站蜘蛛池模板: 欧美肥胖老太vidio在线视频| 少妇一晚三次一区二区三区| 蜜桃臀无码内射一区二区三区| 丰满人妻被中出中文字幕| 另类 专区 欧美 制服| 久久久这里只有精品10| 久热这里只有精品99在线观看| 青青草国产精品久久久久| 亚洲精品无码久久久| 国产97色在线 | 亚洲| www国产亚洲精品久久麻豆| 综合无码成人aⅴ视频在线观看| 九九久久精品国产波多野结衣| 亚洲永久无码7777kkk | 人妻无码一区二区三区 tv| 热99re久久精品天堂| 人妻熟妇乱又伦精品视频无广告| 成人综合婷婷国产精品久久蜜臀| 少妇性俱乐部纵欲狂欢电影| 丰满多毛的陰户视频| 欧洲美熟女乱又伦av| 亚洲人成网网址在线看| 国产精品毛片一区二区| 久久青青草原国产免费播放| 久久精品成人欧美大片| av大片在线无码免费| 欧美老妇与zozoz0交| 8av国产精品爽爽ⅴa在线观看| 黑人巨大videos精品| 精品三级久久久久电影网| 四虎影视在线影院在线观看免费视频| 手机看片福利一区二区三区| 亚洲国产专区校园欧美| 在教室伦流澡到高潮h麻豆| 色老头在线一区二区三区| 亚洲精品97久久中文字幕无码 | 97免费人妻在线视频| 丰满少妇69激情啪啪无| 成年女人午夜毛片免费视频| 久久国产精品日本波多野结衣| 朝鲜女人大白屁股ass孕交 |