在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

LBR Antibody

  • 中文名稱:
    LBR兔多克隆抗體
  • 貨號:
    CSB-PA012776GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    DHCR 14B antibody; DHCR14B antibody; Integral nuclear envelope inner membrane protein antibody; Lamin-B receptor antibody; LBR antibody; LBR_HUMAN antibody; LMN 2R antibody; LMN2R antibody; MGC9041 antibody; PHA antibody; PRO0650 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human LBR
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis. Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation. Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation. Anchors the lamina and the heterochromatin to the inner nuclear membrane.
  • 基因功能參考文獻:
    1. The authors demonstrate that human LBR is essential for cholesterol synthesis. PMID: 27336722
    2. These observations point to a new mechanism regulating the localization of LBR, which is governed by an ELYS-mediated phosphorylation network. PMID: 27802161
    3. The primary response of cells to various stresses leading to senescence consists of the down-regulation of LBR and LB1 to attain reversal of the chromatin architecture. PMID: 27760841
    4. We have shown here that lamin B receptor (LBR) showed a change in localization in both BrdU-induced and replicative senescent cells. PMID: 27059139
    5. Data indicate that proto-oncogene protein c-akt (Akt) phosphorylates distinct sites than SRPK1 protein within the arginine-serine (RS) domain of Lamin B Receptor (LBR). PMID: 27105349
    6. Lamin B receptor mRNA expression was directly associated with tumor grade in breast cancer patients(grade 1 vs. grade 3 - 0.00 vs. 0.00; p = 0.0479) and Nottingham Prognostic Index (NPI1 vs. NPI3 - 0.00 vs. 0.00; p = 0.0551). PMID: 24293108
    7. Mutation in LBR gene is associated with pelger-huet anomaly and a mild skeletal phenotype. PMID: 23824842
    8. Lymphohematopoietic licence: sterol C-14 reductase activity of lamin B receptor (Lbr) is essential for neutrophil differentiation. PMID: 22581323
    9. LBR missense mutations can abolish sterol reductase activity, causing lethal Greenberg dysplasia but not Pelger anomaly PMID: 21327084
    10. The LBR knockdown cells retain an ovoid shaped nucleus with reduced levels of lamin A/C during in vitro granulopoiesis induced with retinoic acid. PMID: 21327094
    11. Our studies reveal for the first time a mechanism that controls the timing of nuclear envelope reassembly through modification of the integral nuclear membrane protein lamin B receptor PMID: 21795390
    12. a highly significant gene-dosage effect between the gene copy number and the nuclear segmentation index of neutrophils PMID: 21326950
    13. LBR is heavily expressed in papillary thyroid carcinoma cells, but an abnormal folding of the protein might explain its lack of immunohistochemical reactivity and be associated with the anomalous folding of the nuclear membrane. PMID: 21103616
    14. LBR targets the membrane precursor vesicles to chromatin by interacting with importin beta in a LBR phosphorylation-dependent manner during the NE assembly at the end of mitosis PMID: 20576617
    15. LBR mutant variants and sterol reductases can severely interfere with the regular organization of the nuclear envelope and the endoplasmic reticulum. PMID: 19940018
    16. results suggest that LMNA, ZMPSTE24, and LBR sequence variations are not major genetic determinants involved in scleroderma pathogenesis PMID: 19645629
    17. The binding of lamin B receptor to chromatin is regulated by phosphorylation in the arginine-serine repeat-containing REGION PMID: 11846796
    18. Mutations in the gene encoding the lamin B receptor produce an altered nuclear morphology in granulocytes (Pelger-Huet anomaly). PMID: 12118250
    19. Autosomal recessive HEM/Greenberg skeletal dysplasia is caused by 3 beta-hydroxysterol delta 14-reductase deficiency due to mutations in this gene. PMID: 12618959
    20. examination of temporal association with protamine 1 during spermiogenesis PMID: 14701833
    21. SR protein kinase and cdc2 kinase regulate lamin B receptor binding to chromatin PMID: 14718546
    22. MeCP2 interacts in vitro and in vivo with the inner nuclear membrane protein LBR, and the unstructured aminoacidic sequence linking the MBD and TRD domains of MeCP2 is responsible for this association. PMID: 19331822

    顯示更多

    收起更多

  • 相關疾病:
    Pelger-Huet anomaly (PHA); Greenberg dysplasia (GRBGD); Reynolds syndrome (REYNS)
  • 亞細胞定位:
    Nucleus inner membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. Cytoplasm. Nucleus.
  • 蛋白家族:
    ERG4/ERG24 family
  • 組織特異性:
    Expressed in the bone marrow, liver, heart, adrenal gland, lung, placenta and uterus. Expressed in osteoclasts and osteoblast-like cells.
  • 數據庫鏈接:

    HGNC: 6518

    OMIM: 169400

    KEGG: hsa:3930

    STRING: 9606.ENSP00000272163

    UniGene: Hs.435166



主站蜘蛛池模板: 狠狠久久久久综合成人影院| 国产av无码专区国产乱码| 亚洲成av人片在一线观看| 欧美老熟妇xb水多毛多| 国产aⅴ激情无码久久久无码| 亚洲综合精品第一页| 影视av久久久噜噜噜噜噜三级| 精品国产一区二区三区久久| 香港三级精品三级在线专区| 无人区码一码二码w358cc| 理论片午午伦夜理片影院| 免费不卡无码av在线观看| 国产成人av一区二区在线观看| 性欧美大胆免费播放| 无码h肉在线观看免费一区| 国产精品卡1卡2卡3网站| 亚洲高清国产拍精品闺蜜合租| 男女性色大片免费网站| 女人被狂躁c到高潮喷水电影| 日射精情感性色视频| 亚洲日韩中文字幕在线播放| 国产人妻人伦精品1国产丝袜| 国产无夜激无码av毛片| 亚洲精品无码中文久久字幕| 丰满亚洲大尺度无码无码专线| 亚洲欧洲免费无码| 亚洲va综合va国产产va中文| 真人啪啪高潮喷水呻吟无遮挡| 国语自产偷拍精品视频偷| 国产精品久久久久久妇女| 香蕉精品亚洲二区在线观看| 欧美日韩一本的免费高清视频| 性xxxx18免费观看视频| 国产精品自在在线午夜出白浆| 国产av中文av无码av狼人| 涩涩鲁亚洲精品一区二区| 国产伦精品一区二区三区免费| 久久久久国产精品人妻aⅴ院| 久久99久久99久久综合| 亚洲色欲色欲www| 97超碰精品成人国产|