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IL2RA

白介素-2受體α亞基(IL2RA)也被稱為Tac抗原、P55、CD25,是一種細(xì)胞表面蛋白,與β亞基(CD122)、γ亞基(CD132)共同組成白介素-2受體。該蛋白主要參與免疫細(xì)胞的信號(hào)傳遞,尤其在維持免疫耐受和調(diào)節(jié)性T細(xì)胞功能中起核心作用。IL2RA在免疫系統(tǒng)中發(fā)揮重要作用,與T細(xì)胞的增殖、存活和分化密切相關(guān)。IL2RA蛋白的表達(dá)和功能異常與類風(fēng)濕性關(guān)節(jié)炎、1型糖尿病等疾病的發(fā)生發(fā)展密切相關(guān)。首個(gè)基于IL-2的藥物(aldesleukin:重組IL-2)于1992年被FDA批準(zhǔn),用于治療轉(zhuǎn)移性腎癌;1998年,該藥又被批準(zhǔn)用于治療轉(zhuǎn)移性黑色素瘤。目前,IL2RA作為免疫調(diào)節(jié)研究領(lǐng)域的熱點(diǎn),相關(guān)藥物研發(fā)仍在持續(xù)進(jìn)行中。

熱銷產(chǎn)品

Recombinant Human Interleukin-2 receptor subunit alpha (IL2RA), partial (Active) (CSB-MP011649HU3)

驗(yàn)證數(shù)據(jù)

CSB-MP011649HU3

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP011649HU3

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human IL2RA at 2μg/mL can bind Anti-IL2RA recombinant antibody (CSB-RA011649MA1HU),the EC50 is 2.463-3.353 ng/mL.

CSB-MP011649HU3

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human IL2RA at 2μg/mL can bindHuman IL2(CSB-MP011629HU),the EC50 is 1.693-2.039 ng/mL.

IL2RA (Basiliximab) Recombinant Monoclonal Antibody (CSB-RA011649MA1HU)

驗(yàn)證數(shù)據(jù)

CSB-RA011649MA1HU

The Binding Activity of Human IL2RA with Anti-IL2RA Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human IL2RA (CSB-MP011649HU3) at 2 μg/mL can bind Anti-IL2RA recombinant antibody , the EC50 is 2.463-3.353 ng/mL.

CSB-RA011649MA1HU

Immunofluorescence staining of Hela cell with CSB-RA011649MA1HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-human IgG(H+L).

CSB-RA011649MA1HU

Immunofluorescence staining of HEPG2 cell with CSB-RA011649MA1HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-human IgG(H+L).

Human soluble interleukin-2 receptor,IL-2sRα ELISA kit (CSB-E04629h)

驗(yàn)證數(shù)據(jù)

CSB-E04629h 標(biāo)準(zhǔn)曲線

貨號(hào):CSB-E04629h

規(guī)格:96T/48T

靈敏度:19.5 pg/mL

檢測范圍:78 pg/mL-5000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

IL2RA Antibodies

IL2RA for H

IL2RA for Homo sapiens (Human)

IL2RA Proteins

IL2RA Proteins for Bos taurus (Bovine)

IL2RA Proteins for Ovis aries (Sheep)

IL2RA Proteins for Felis catus (Cat) (Felis silvestris catus)

IL2RA Proteins for Rattus norvegicus (Rat)

IL2RA Proteins for Homo sapiens (Human)

IL2RA Proteins for Mus musculus (Mouse)

IL2RA Proteins for Sus scrofa (Pig)

IL2RA Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

IL2RA Proteins for Pan troglodytes (Chimpanzee)

IL2RA Proteins for Macaca mulatta (Rhesus macaque)

IL2RA ELISA Kit

IL2RA ELISA Kit for Homo sapiens (Human)

IL2RA ELISA Kit for Mus musculus (Mouse)



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