在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

IL2RA Antibody, Biotin conjugated

  • 中文名稱:
    IL2RA兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA011649LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) IL2RA Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    IL2RA; Interleukin-2 receptor subunit alpha; IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2-RA; TAC antigen; p55; CD antigen CD25
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Interleukin-2 receptor subunit alpha protein (22-185AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.
  • 基因功能參考文獻:
    1. Results are in line with the hypothesis that in the early phase of ALS, neuroprotective helper T cells infiltrate in the affected areas in the lumbar spinal cord. This was reflected in higher peripheral percentage of CD4(+) helper T cells and higher expression of FOXP3 and IL-2Ralpha. PMID: 29574662
    2. a significant association was found between IL2RA SNP and susceptibility to alopecia areata in Iranian cohort PMID: 29979892
    3. The gene polymorphisms at the loci of IL2RA rs2104286 and rs12722489 are closely associated with susceptibility to MS in the Chinese. PMID: 30352019
    4. Higher frequency of IL2RA SNP could not be detected among multiple sclerosis patients. The difference of frequencies was statistically insignificant between groups, probably, due to low power of analysis and inadequate sample size. PMID: 29141792
    5. Our meta-analysis suggests that the rs2104286 A allele is associated with increased MS risk in both Caucasians and Asians, whereas the rs12722489 C allele is associated with elevated MS risk in Caucasians but not in Asians. PMID: 29648897
    6. sIL-2R could be a promising new marker for determining inflammatory disease activity in CRPS. PMID: 28634419
    7. Relationship between soluble CD25 and gene expression in healthy individuals and patients with multiple sclerosis. PMID: 28511943
    8. Increased serum level of soluble interleukin-2 receptor is associated with a worse response of metastatic clear cell renal cell carcinoma to interferon alpha and sequential VEGF-targeting therapy. PMID: 28545581
    9. Data show that interleukin-2 receptor alpha, tumor necrosis factor receptor 1, serum STimulation-2 (IL1RL1 gene product), and regenerating islet-derived 3-alpha were significantly associated with non-relapse mortality. PMID: 28126963
    10. High IL2RA expression is associated with CRLF2-rearranged acute lymphoblastic leukemia. PMID: 28866095
    11. Inhibits CD25 translation through regulation of the LKB1-AMPK-mTOR pathway to suppress T cells. PMID: 28230853
    12. Among patients with a low pretreatment sIL-2R level who exhibited a positive response to R-CHOP, the posttreatment sIL-2R level may help to identify those with a poor prognosis. PMID: 28413914
    13. The findings not only confirm the predictive power of CD25 expression for Philadelphia chromosome translocation (Ph)+ but also demonstrate that CD25 expression is associated with RD (a biomarker correlated with prognosis) in Ph- patients. The latter finding is likely associated with underlying molecular abnormalities, including Ph-like genotype. PMID: 28430957
    14. Through GWAS, we found that emotion dysregulation is associated at genome-wide level significance in a sex-specific manner, with a SNP in IL2RA in men. PMID: 27643478
    15. it has been shown that CD25 serves as a negative growth regulator of Chronic myeloid leukemia leukemic stem cells. PMID: 28457753
    16. Decidual stromal cells affect IL-2 production and IL-2R expression and signaling. PMID: 27651429
    17. The single nucleotide variant rs12722489 determines differential ERalpha binding and enhancer properties of an IL2RA intronic region. PMID: 28234966
    18. CDK6-mediated suppression of CD25 is required for initiation of T-ALL by activated Notch1 PMID: 26707936
    19. CD4(+) CD25(+) GARP(+) Treg cells are defective in dilated cardiomyopathy patients and GARP seems to be a better molecular definition of the regulatory phenotype. PMID: 28207945
    20. Studies indicate many potential uses of soluble interleukin-2 receptor measurement in the diagnosis and treatment of hemophagocytic syndromes. PMID: 28497365
    21. Data suggest that differential methylation of the IL2RA promoter in T cells could be an important pathogenic mechanism in multiple sclerosis. PMID: 28077880
    22. Sustained STAT5 transcription factor (STAT5) phosphorylation is necessary to induce long-term interleukin 2 receptor subunit alpha (CD25) expression in T lymphocytes. PMID: 27936140
    23. Gastric adenocarcinoma patients present with increased PD-1(+) lymphocytes and CD4(+)CD25(+)FOXP3(+) regulatory T cells in the peripheral blood. PMID: 28031121
    24. The serum concentration of soluble IL2 receptor are increased in patients with Kawasaki disease. (Review) PMID: 28081636
    25. CD25 is an independent prognostic factor in elderly AML patients. Alternative therapies for CD25-positive elderly AML patients are needed. PMID: 28097942
    26. The study demonstrated Increased level of CD25 in patients with active vitilligo. PMID: 27556155
    27. CD45RA distinguishes CD4+CD25+CD127-/low TSDR demethylated regulatory T cell subpopulations with differential stability and susceptibility to tacrolimus-mediated immunosuppression. PMID: 28118317
    28. Combination with anti-programmed cell death protein-1 (PD-1) antibodies promoted complete tumor rejection, indicating the relevance of CD25 antigen as a therapeutic target and promising substrate for future combination approaches in immune-oncology. PMID: 28410988
    29. A compensatory mechanism of IL-7-mediated homeostatic proliferation can restore the inhibitory network of CD24+Foxp3+Treg cell after anti-CD25 induction therapy in islet allotransplantation. PMID: 27306531
    30. (99) Tc-methylene diphosphonate may improve the activity of RA through upregulating the frequency of peripheral gammadelta T cells and CD4(+) CD25(+) Foxp3(+) Tregs as well as affecting the serum cytokine environment by increasing TGF-beta and decreasing TNF-alpha and IL-6. PMID: 24467668
    31. IL-2Ra Interleukin-2 receptor antagonists (IL-2Ra) reduces the risk on new-onset diabetes after transplantation (NODAT) in liver transplant recipients. PMID: 26588180
    32. The percentages of CD8(+)CD25(+)FoxP3(brigh) Tregs correlate with mean peak expiratory flow. PMID: 25921629
    33. Efficiently downregulated the percentages of CD4+CD25+Foxp3+ regulator T (Treg) cells. PMID: 27431260
    34. introduce the combined use of CD25 and properly strati fi ed CD135 values as alternatives to testing for the FLT3-ITD mutation PMID: 27087256
    35. this study shows that PTPN22 genetic polymorphisms play role in predisposition of type 1 diabetes mellitus in Egyptian children PMID: 27288719
    36. dissected the first intron of the IL2RA gene and selected several single nucleotide polymorphisms (SNPs) that may influence the regulation of the IL2RA gene in cell types relevant to autoimmune pathology PMID: 27876533
    37. Its levels correlate to disease stage, assess response to therapy and are predictive of recurrence or better survival. We suggest, therefore, using sIL-2R as a reliable prognostic marker in HNC patients as a single marker, or in a combined panel of biomarkers. PMID: 27466555
    38. CD25 had an adverse prognostic impact on these patients, and this poor prognosis may not be overcome, even with transplant. Patients with AML with residual CD25-positive blasts at the time of transplant may require additional therapy before or after transplant to improve survival. PMID: 26422713
    39. IL2RA and TAGAP are novel vitamin D target genes. The vitamin D response is observed in samples from both the multiple sclerosis (MS) patients and controls, and is not dependent on the genotype of MS-associated SNPs in the respective genes. PMID: 26765264
    40. Anti-CD25 recombinant immunotoxin LMB-2 had phase I activity limited by immunogenicity and rapid growth. PMID: 26350263
    41. Enhanced pretreatment CD25 expression on CD4+ T cells was associated with decreased survival rate of acute myeloid leukemia patients. PMID: 26721345
    42. A decrease of CD4(+) CD25(+) CD127(low) FoxP3(+) regulatory T cells with impaired suppressive function had been found in untreated ulcerative colitis patients. PMID: 26333292
    43. Data show that an ultra-high level of serum serum soluble interleukin-2 receptor (sIL-2R) at diagnosis is a significant poor prognostic biomarker for angioimmunoblastic T-cell lymphoma (AITL). PMID: 25563559
    44. The rs2104286 G allele in IL2RA is present at higher frequencies in neuromyelitis optica patients than in healthy controls within a Southern Han Chinese population. PMID: 24257225
    45. Our results suggest that the CD34/CD25/CD123/CD99(+) LAIP is strictly associated with FLT3-ITD-positive cells. PMID: 25957287
    46. Interleukin-2 Receptor alpha-Chain (CD25) Expression Predicts a Poor Prognosis in Acute Myeloid Leukemia PMID: 26375984
    47. Data show that interleukin 2 receptor subunit alpha (IL2RA)-single nucleotide polymorphism rs2104286 and serum sIL2Ralpha-level associated with rheumatoid arthritis (RA)-persistence. PMID: 26350950
    48. CD4+CD45RO+CD25-/lowCD127+: CD4+CD45RO+CD25hiCD127-/low ratio in peripheral blood indicates heart transplant recipients at risk for cardiac allograft vasculopathy. PMID: 25539460
    49. analysis of sIL-2R levels in sarcoidosis patients with renal insufficiency PMID: 25745051
    50. all five single nucleotide polymorphisms in the IL2RA gene are risk factors for type 1 diabetes risk. PMID: 26249556

    顯示更多

    收起更多

  • 相關疾病:
    Diabetes mellitus, insulin-dependent, 10 (IDDM10); Immunodeficiency 41 with lymphoproliferation and autoimmunity (IMD41)
  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein.
  • 數據庫鏈接:

    HGNC: 6008

    OMIM: 147730

    KEGG: hsa:3559

    STRING: 9606.ENSP00000369293

    UniGene: Hs.231367



主站蜘蛛池模板: 日韩av无码久久一区二区| 成人网站www污污污网站 | 精品国产aⅴ无码一区二区| 少妇被粗大猛进进出出s小说 | 99精品电影一区二区免费看| 樱花影院电视剧免费| 99久久无码一区人妻a黑| 在线天堂最新版资源| 沈阳45老熟女高潮喷水亮点| 成人国产欧美大片一区| 欧美日激情日韩精品嗯| 少妇熟女久久综合网色欲| 亚洲日本成本人观看| 亚洲另类春色校园小说| 偷看农村女人做爰毛片色| 久久久国产精品va麻豆| 欧美精品一产区二产区| 伴郎粗大的内捧猛烈进出视频观看| 亚洲一区精品无码| 中文字幕av久久激情亚洲精品 | 中国猛少妇色xxxxx| 亚洲a∨无码无在线观看| 天天做天天躁天天躁| 成人免费午夜无码视频在线播放| 天天天狠天天碰天天爱| 97伦伦午夜电影理伦片| 精品性高朝久久久久久久| 欧洲精品va无码一区二区三区| 亚洲男人天堂| 人人爽人人爽人人爽人人片av| 日本xxxx色视频在线观看| 人妻三级日本三级日本三级极| 同性男男黄g片免费网站| 亚洲欧美日本韩国| 12裸体自慰免费观看网站| 朋友的丰满人妻中文字幕| 特级做a爰片毛片免费69| 亚洲成a人片在线观看无码下载| 日韩视频无码免费一区=区三区| 最新国产在线拍揄自揄视频| 欧美丰满一区二区免费视频|