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FZD3

Frizzled-3 is a protein in humans that is encoded by FZD3 gene. Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

FZD3 Antibodies

FZD3 for Homo sapiens (Human)

FZD3 Proteins

FZD3 Proteins for Xenopus laevis (African clawed frog)

FZD3 Proteins for Mus musculus (Mouse)

FZD3 Proteins for Homo sapiens (Human)

FZD3 Proteins for Gallus gallus (Chicken)



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