在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. FZD3 Antibody

FZD3 Antibody

  • 中文名稱：
    FZD3兔多克隆抗體
  • 貨號：
    CSB-PA002580
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of RAW264.7 cells using Frizzled-3 Polyclonal Antibody
    • Western Blot analysis of A549 cells using Frizzled-3 Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    FZD3; Frizzled-3; Fz-3; hFz3
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Frizzled-3.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IF, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Required for the development of major fiber tracts in the central nervous system, including: the anterior commissure, the corpus callosum, the thalamocortical, corticothalamic and nigrostriatal tracts, the corticospinal tract, the fasciculus retroflexus, the mammillothalamic tract, the medial lemniscus, and ascending fiber tracts from the spinal cord to the brain. In the peripheral nervous system, controls axon growth in distinct populations of cranial and spinal motor neurons, including the facial branchimotor nerve, the hypoglossal nerve, the phrenic nerve, and motor nerves innervating dorsal limbs. Involved in the migration of cranial neural crest cells. May also be implicated in the transmission of sensory information from the trunk and limbs to the brain. Controls commissural sensory axons guidance after midline crossing along the anterior-posterior axis in the developing spinal cord in a Wnt-dependent signaling pathway. Together with FZD6, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle in a beta-catenin-dependent manner.
  • 基因功能參考文獻：
    1. This study identified Circular RNA circ-CBFB as a sponge of miR-607, which targeted FZD3. PMID: 29902450
    2. schizophrenia may be related to some polymorphisms of gene FZD3 that are in stronger linkage disequilibrium to Chinese than to the other populations studied (Meta-Analysis) PMID: 27755292
    3. marked reduction in the prominence of TUJ1 bundles in number, thickness, and length. Our results showed that deregulation of the planar cell polarity genes CELSR3 and FZD3 might disrupt the enteric innervation pattern PMID: 27619161
    4. seven-transmembrane domain receptors Celsr3 and Fzd3, in particular, control the development of most longitudinal tracts in the central nervous system. [Review] PMID: 25813877
    5. Our analysis showed no significant association between the rs2241802 polymorphism in FZD3 gene and neural tube defects PMID: 24816679
    6. DNA methylation aberrations rather than polymorphisms of FZD3 gene increase the risk of spina bifida in a high-risk region for neural tube defects. PMID: 25131656
    7. Wnt3a/Frizzled-3 signaling plays important role in regulating the proliferation and differentiation of neural crest cells and various developmental stages of melanocyte precursors. PMID: 24815018
    8. Aberrant methylation modification of the FZD3 gene increases the risk of congenital hydrocephalus by altering chromatin structure and disturbing gene expression. PMID: 24796881
    9. FZD3 signaling sensitized peripheral sensory neurons in pain hypersensitivity. PMID: 24991956
    10. clinical significance of frizzled homolog 3 protein in colorectal cancer patients PMID: 24255701
    11. Genetic variants of the FZD3 gene may affect susceptibility to schizophrenia in Chinese Han and Va populations. PMID: 22027177
    12. This study found a significant association between schizophrenia and the FZD3 gene in single nucleotide polymorphisms and haplotype analyses. PMID: 14642436
    13. Results suggested that the FZD3 gene might be involved in the predisposition to schizophrenia. PMID: 15274031
    14. The FZD3 gene does not play a role in conferring susceptibility to schizophrenia variants in a Japanese sample. PMID: 15657645
    15. In German patients, neither single markers nor haplotypes in FZD3 were associated with schizophrenia. Further exploratory analyses using a different diagnostic approach did also not yield significant results. PMID: 17982906
    16. Fzd3 is expressed in Ewing sarcoma family tumor cell lines. Fzd3 mediated Wnt-3a-dependent neurite outgrowth. PMID: 18212053

    顯示更多

    收起更多

  • 亞細胞定位：
    Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell surface. Apical cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor Fz/Smo family
  • 組織特異性：
    Widely expressed. Relatively high expression in the CNS, including regions of the limbic system, in kidney, pancreas, skeletal muscle, uterus and testis.
  • 數據庫鏈接：

    HGNC: 4041

    OMIM: 606143

    KEGG: hsa:7976

    STRING: 9606.ENSP00000240093

    UniGene: Hs.40735



主站蜘蛛池模板： 欧美偷窥清纯综合图区| 最新国产av无码专区亚洲| 一区二区三区国产| 久久综合88熟人妻| 国产精品国语对白露脸在线播放 | 少妇扒开粉嫩小泬视频| 少妇无套内谢久久久久| 日本少妇xxx做受| 亚洲 熟女 久久 国产| 国产午夜精品av一区二区| 人妻无码中文字幕| 亚洲成av人无码中文字幕| 亚洲人成色77777在线观看大战p| 亚洲午夜未满十八勿入网站| 两根大肉大捧一进一出好爽视频| 国产又黄又潮娇喘视频在线观看| 免费看国产zzzwww色| 东京热无码av一区二区| 国产精品无码av天天爽播放器 | 男ji大巴进入女人的视频小说| 亚洲大成色www永久网站动图| 欧美大波少妇在厨房被| 欧美与黑人午夜性猛交久久久 | 欧美黑吊大战白妞| 无码人妻丰满熟妇啪啪| 欧美xxxx做受欧美1314| 国产av国片精品一区二区| 暖暖视频日本| 好爽毛片一区二区三区四| 亚洲乱码卡一卡二卡| 三级特黄60分钟在线观看| 亚洲日韩成人无码| 亚洲色在线v中文字幕| 人人爽人人澡人人人人妻| 国模丽丽啪啪一区二区| 欧美高清性色生活片免费观看 | 在线欧美日韩制服国产| 日韩人妻无码精品二专区| 久久综合香蕉国产蜜臀av| 国产精品igao视频网网址| 国产精品嫩草影院免费观看|