FPGS
FPGS,即葉酰聚谷氨酸合酶,別名Folylpoly-gamma-glutamatesynthetase, 是一種在人類細胞中表達的酶,對于葉酸穩態和增殖細胞的存活至關重要。FPGS的作用機制是通過催化ATP依賴的谷氨酸部分添加到葉酸和葉酸衍生物中,從而在細胞溶質和線粒體內建立和維持葉酰聚谷氨酸濃度。這種酶的活性對于甲氨蝶呤(MTX)類藥物的細胞內代謝過程非常關鍵,它催化形成MTX多聚谷氨酸,這是MTX發揮抗腫瘤作用的活性形式。FPGS的異常表達或活性降低可能導致MTX耐藥,在癌癥治療中,FPGS的表達和活性是影響藥物敏感性的重要因素。
熱銷產品
FPGS Recombinant Monoclonal Antibody (CSB-RA983477A0HU)
驗證數據

Overlay Peak curve showing HepG2 cells stained with CSB-RA983477A0HU (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
FPGS Antibodies
FPGS for Homo sapiens (Human)
產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
---|---|---|---|
CSB-PA23719A0Rb | FPGS Antibody | Human | ELISA, WB |
CSB-PA23719B0Rb | FPGS Antibody, HRP conjugated | Human | ELISA |
CSB-PA23719C0Rb | FPGS Antibody, FITC conjugated | Human | |
CSB-PA23719D0Rb | FPGS Antibody, Biotin conjugated | Human | ELISA |
CSB-RA983477A0HU | FPGS Recombinant Monoclonal Antibody | Human | ELISA, FC |