在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CX3CR1

CX3CR1全稱為CX3C趨化因子受體1,也被稱為Fractalkine受體或G蛋白偶聯(lián)受體13。這種蛋白主要分布在單核細(xì)胞、小膠質(zhì)細(xì)胞和自然殺傷細(xì)胞表面,通過(guò)與其配體Fractalkine的相互作用,調(diào)控免疫細(xì)胞的遷移與黏附功能,尤其在炎癥反應(yīng)和免疫監(jiān)視中發(fā)揮重要作用。研究發(fā)現(xiàn),CX3CR1介導(dǎo)的細(xì)胞間通訊與神經(jīng)退行性疾病密切相關(guān),例如阿爾茨海默病患者腦內(nèi)小膠質(zhì)細(xì)胞的異常激活便與其功能失調(diào)存在關(guān)聯(lián)。此外,該受體在動(dòng)脈粥樣硬化斑塊形成過(guò)程中參與單核細(xì)胞的浸潤(rùn),與心血管疾病的發(fā)展密切相關(guān)。
近年來(lái),針對(duì)CX3CR1的藥物開發(fā)聚焦于炎癥性疾病治療領(lǐng)域。部分小分子抑制劑已在動(dòng)物模型中展現(xiàn)出抑制神經(jīng)炎癥和延緩動(dòng)脈斑塊進(jìn)展的效果。臨床前研究還發(fā)現(xiàn),阻斷CX3CR1可能緩解類風(fēng)濕性關(guān)節(jié)炎的關(guān)節(jié)損傷。目前已有單克隆抗體類藥物進(jìn)入早期臨床試驗(yàn)階段,嘗試通過(guò)調(diào)控免疫細(xì)胞遷移來(lái)治療多發(fā)性硬化等自身免疫疾病。與此同時(shí),該受體在腫瘤微環(huán)境中的雙重作用也引起關(guān)注,既有研究支持其促進(jìn)腫瘤免疫逃逸,也有證據(jù)表明可能增強(qiáng)抗腫瘤免疫應(yīng)答,這一矛盾特性為靶向治療帶來(lái)挑戰(zhàn)。

熱銷產(chǎn)品

CX3CR1 Antibody (CSB-PA006236LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA006236LA01HU

Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA006236LA01HU at dilution of 1:100

CSB-PA006236LA01HU

Immunofluorescent analysis of HepG2 cells using CSB-PA006236LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Human CX3C-chemokine receptor 1,CX3CR1 ELISA Kit (CSB-E09942h)

驗(yàn)證數(shù)據(jù)

CSB-E09942h 標(biāo)準(zhǔn)曲線

貨號(hào):CSB-E09942h

規(guī)格:96T/48T

靈敏度:7.8 pg/mL

檢測(cè)范圍:31.25 pg/mL-2000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

CX3CR1 Antibodies

CX3CR1 for Homo sapiens (Human)

CX3CR1 Proteins

CX3CR1 Proteins for Homo sapiens (Human)

CX3CR1 Proteins for Bos taurus (Bovine)

CX3CR1 Proteins for Rattus norvegicus (Rat)

CX3CR1 Proteins for Oryctolagus cuniculus (Rabbit)

CX3CR1 Proteins for Mus musculus (Mouse)

CX3CR1 ELISA Kit

CX3CR1 ELISA Kit for Homo sapiens (Human)

CX3CR1 ELISA Kit for Rattus norvegicus (Rat)