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  4. Rat CX3C chemokine receptor 1(CX3CR1) ELISA kit

Rat CX3C chemokine receptor 1(CX3CR1) ELISA kit

  • 中文名稱：
    大鼠CX3C趨化因子受體1(CX3CR1)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL006236RA
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    大鼠CX3C趨化因子受體1(CX3CR1)酶聯(lián)免疫試劑盒（CSB-EL006236RA）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、細(xì)胞裂解物樣本中的CX3CR1含量。CX3CR1，全稱chemokine (C-X3-C motif) receptor 1，是一種趨化因子受體，其與CX3CL1結(jié)合后介導(dǎo)免疫細(xì)胞趨化或粘附，與動脈粥樣硬化、神經(jīng)炎癥、神經(jīng)退行性疾病、癌癥等密切相關(guān)。研究顯示，CX3CR1通過調(diào)節(jié)巨噬細(xì)胞極化影響腎間質(zhì)纖維化，其信號識別與轉(zhuǎn)導(dǎo)機(jī)制正被深入研究。試劑盒檢測范圍為23.5 pg/mL-1500 pg/mL，適用于基礎(chǔ)科研領(lǐng)域中對CX3CR1表達(dá)調(diào)控機(jī)制的研究，例如在神經(jīng)系統(tǒng)疾病模型（如阿爾茨海默病、帕金森病）、免疫微環(huán)境分析或藥物干預(yù)實驗中的分子水平檢測，為探索疾病機(jī)制或潛在治療靶點(diǎn)提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Cx3cr1; Rbs11; CX3C chemokine receptor 1; C-X3-C CKR-1; CX3CR1; Fractalkine receptor
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍：
    23.5 pg/mL-1500 pg/mL
  • 靈敏度：
    5.8 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of rat CX3CR1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %92
    Range %87-95
    1:2Average %105
    Range %99-108
    1:4Average %90
    Range %85-93
    1:8Average %95
    Range %91-98
  • 回收率：
    The recovery of rat CX3CR1 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9287-94
    EDTA plasma (n=4)10799-111
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    15002.191 2.124 2.158 2.035
    7501.445 1.452 1.449 1.326
    3751.088 1.051 1.070 0.947
    187.50.634 0.622 0.628 0.505
    940.372 0.389 0.381 0.258
    470.288 0.278 0.283 0.160
    23.50.210 0.207 0.209 0.086
    00.124 0.122 0.123
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Receptor for the C-X3-C chemokine fractalkine (CX3CL1) present on many early leukocyte cells; CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis. CX3CR1-CX3CL1 signaling mediates cell migratory functions. Responsible for the recruitment of natural killer (NK) cells to inflamed tissues. Acts as a regulator of inflammation process leading to atherogenesis by mediating macrophage and monocyte recruitment to inflamed atherosclerotic plaques, promoting cell survival. Involved in airway inflammation by promoting interleukin 2-producing T helper (Th2) cell survival in inflamed lung. Involved in the migration of circulating monocytes to non-inflamed tissues, where they differentiate into macrophages and dendritic cells. Acts as a negative regulator of angiogenesis, probably by promoting macrophage chemotaxis. Plays a key role in brain microglia by regulating inflammatory response in the central nervous system (CNS) and regulating synapse maturation. Required to restrain the microglial inflammatory response in the CNS and the resulting parenchymal damage in response to pathological stimuli. Involved in brain development by participating in synaptic pruning, a natural process during which brain microglia eliminates extra synapses during postnatal development. Synaptic pruning by microglia is required to promote the maturation of circuit connectivity during brain development. Acts as an important regulator of the gut microbiota by controlling immunity to intestinal bacteria and fungi. Expressed in lamina propria dendritic cells in the small intestine, which form transepithelial dendrites capable of taking up bacteria in order to provide defense against pathogenic bacteria. Required to initiate innate and adaptive immune responses against dissemination of commensal fungi (mycobiota) component of the gut: expressed in mononuclear phagocytes (MNPs) and acts by promoting induction of antifungal IgG antibodies response to confer protection against disseminated C.albicans or C.auris infection. Also acts as a receptor for C-C motif chemokine CCL26, inducing cell chemotaxis.
  • 基因功能參考文獻(xiàn)：
    1. The present study revealed an involvement of NF-kappaB and the CX3CL1/CX3CR1 axis in Tetanic Sciatic Stimulation-induced pathological pain. PMID: 28612319
    2. Results suggest fractalkine-CX3CR1 signaling pathway role in limbic seizure-induced hippocampal pathologies including microglial activation, neurodegeneration and neuroblast production PMID: 25461978
    3. Results suggest that CX3C chemokine receptor 1 (CX3CR1) activation of pancreatic stellate cells (PSCs) could be important in their effects in pancreatitis, especially to PSCs proliferation in pancreatitis where CX3CL1 levels are elevated. PMID: 24681877
    4. It plays an important role in the neuroinflammatory response PMID: 23855980
    5. TMJ inflammation induced significant upregulation of CX3CR1 in the trigeminal subnucleus caudalis. PMID: 23110394
    6. The microglia CX3CR1/p38 MAP kinase signaling cascade potentially plays an important role in facilitating pain processing in rats with bone cancer pain. PMID: 22613229
    7. FKN, and its receptor, CX3CR1, may modulate cardiovascular responses in the solitary nucleus of normal healthy rats via the phosphoinositide 3-kinase intracellular signaling pathway. PMID: 22387113
    8. Autologous implantation of nucleus pulposus induces hyperalgesia and allodynia leading to upregulation of fractalkine and its receptor in spinal neurons and glia, implicating fractalkine in association with radicular pain. PMID: 21224760
    9. CX3CR1 contributes to the dendritic cell-endothelial cell interaction. PMID: 20364328

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  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 組織特異性：
    Most abundant in adult spinal cord, brain, kidney, gut, uterus and testes.
  • 數(shù)據(jù)庫鏈接：


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