CSPG4
CSPG4全稱為硫酸軟骨素蛋白聚糖4(Chondroitin Sulfate Proteoglycan 4),又名神經膠質抗原NG2或黑色素瘤相關硫酸軟骨素蛋白聚糖(MCSP),是一種跨膜糖蛋白。其結構包含可結合硫酸軟骨素鏈的胞外區域,廣泛表達于血管周細胞及多種惡性腫瘤細胞表面,尤其在黑色素瘤、膠質瘤、乳腺癌中異常高表達。CSPG4通過調控細胞與微環境的相互作用,促進腫瘤細胞遷移、侵襲及血管生成,其活性與整合素、生長因子受體等分子存在交叉對話,影響MAPK、PI3K-AKT等促生存信號通路的激活。
CSPG4的過表達與腫瘤復發、耐藥性及不良預后密切相關,成為實體瘤治療的熱門靶點?;诖碎_發的靶向藥物包括單克隆抗體(如mAb 9.2.27)、抗體藥物偶聯物以及CAR-T細胞療法,其中部分已進入黑色素瘤的臨床試驗階段。CSPG4在創傷修復和纖維化疾病中的作用也受到關注,例如肺纖維化模型中CSPG4陽性周細胞的異?;罨赡芗觿〗M織損傷。盡管靶向CSPG4的療法尚未上市,但其在腫瘤微環境中的樞紐地位為聯合用藥提供了新思路。
熱銷產品
Recombinant Human Chondroitin sulfate proteoglycan 4 (CSPG4), partial (CSB-MP006076HU)
驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CSPG4 Antibody (CSB-PA006076ESR1HU)
驗證數據

Western blot
All lanes: CSPG4 antibody at 2.51µg/ml + A375 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 251 kDa
Observed band size: 251 kDa

Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA006076ESR1HU at dilution of 1:100
Human Chondroitin sulfate proteoglycan 4(CSPG4) ELISA kit (CSB-EL006076HU)
驗證數據

貨號:CSB-EL006076HU
規格:96T/48T
靈敏度:6.25 pg/mL
檢測范圍:25 pg/mL-1600 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
CSPG4 Antibodies
CSPG4 for Homo sapiens (Human)
產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
---|---|---|---|
CSB-PA006076GA01HU | CSPG4 Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA575237 | CSPG4 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA006076ESR1HU | CSPG4 Antibody | Human | ELISA, WB, IHC |
CSPG4 Proteins
CSPG4 Proteins for Homo sapiens (Human)
產品貨號 | 產品名稱 | 來源 |
---|---|---|
CSB-YP006076HU CSB-EP006076HU CSB-BP006076HU CSB-EP006076HU-B |
Recombinant Human Chondroitin sulfate proteoglycan 4 (CSPG4), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
CSB-MP006076HU | Recombinant Human Chondroitin sulfate proteoglycan 4 (CSPG4), partial | Mammalian cell |
CSPG4 ELISA Kit
CSPG4 ELISA Kit for Homo sapiens (Human)
產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
---|---|---|---|
CSB-EL006076HU | Human Chondroitin sulfate proteoglycan 4(CSPG4) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 6.25 pg/mL |