在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CSPG4 Antibody

  • 中文名稱:
    CSPG4兔多克隆抗體
  • 貨號:
    CSB-PA575237
  • 規(guī)格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA575237(CSPG4 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Mouse skin tissue, Primary antibody: CSB-PA575237(CSPG4 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    4732461B14Rik antibody; AN2 antibody; AN2 proteoglycan antibody; Chondroitin sulfate proteoglycan 4 (melanoma-associated) antibody; Chondroitin sulfate proteoglycan 4 antibody; Chondroitin sulfate proteoglycan NG2 antibody; Cspg4 antibody; Cspg4 chondroitin sulfate proteoglycan 4 antibody; CSPG4_HUMAN antibody; HMW-MAA antibody; HSN tumor-specific antigen antibody; Kiaa4232 antibody; MCSP antibody; MCSPG antibody; MEL-CSPG antibody; Melanoma chondroitin sulfate proteoglycan antibody; Melanoma-associated chondroitin sulfate proteoglycan antibody; MELCSPG antibody; MSK16 antibody; NG2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthetic peptide of Human CSPG4
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:20-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades.
  • 基因功能參考文獻:
    1. DNA methylation status of blood leukocytes may be associated with susceptibility to Colorectal Cancer . The MCSM-H of blood leukocytes may be associated with CRC risk, especially in younger people. PMID: 29291617
    2. This study revealed that CSPG4 interacted with perlecan to support cell adhesion and actin polymerization and the data suggest a novel mechanism by which CSPG4 expressing cells might attach to perlecan-rich matrices so as those found in connective tissues and basement membranes. PMID: 29462330
    3. Both tumor cell and vascular NG2 expression were shown to be present in a significant number of patients with colorectal cancer and this makes NG2 a double target for anti-tumor therapies. PMID: 28715802
    4. NG2 may represent a promising target for the modulation of ICAM-1-mediated immune responses. PMID: 28964848
    5. In addition to establishing the binding region for CSPG4, this work ascribes for the first time a role in TcdB CROPs in receptor binding and further clarifies the relative roles of host receptors in TcdB pathogenesis. PMID: 28842504
    6. of NG2/CSPG4 rather than changes in CD44 or Ki-67 expression is associated with low overall survival in glioblastoma multiforme patients PMID: 28945172
    7. The results indicate that CSPG4/NG2 has roles in regulating chondrosarcoma cell function in relation to growth, spread and resistance to chemotherapy. PMID: 27292772
    8. A positive CSPG4 stain may be associated with an increased risk of metastasis and mortality from chordoma. PMID: 26689475
    9. CSPG4 is a cell surface proteoglycan regulated by interleukin 11 in human endometrial epithelial cancer cells. the data suggest that CSPG4 inhibition may impair endometrial cancer progression by reducing cancer cell proliferation, migration and potentially epithelial-to-mesenchymal transition. PMID: 28098860
    10. These data suggest the possible involvement of GD3 and NG2 in pre/pro-tumorigenic events occurring in the complex microenvironment of the tissue surrounding glioblastoma PMID: 26792897
    11. the ratio of serum proteoglycan 4 to protease C1 inhibitor may be used for screening of early breast cancer. PMID: 26890881
    12. The NG2 proteoglycan protects oligodendrocyte precursor cells against oxidative stress via interaction with OMI/HtrA2. PMID: 26340347
    13. The up-regulation of NG2 is associated with poor prognosis in HCC. PMID: 26074703
    14. Low CSPG4 expression is associated with pancreatic tumors. PMID: 24932730
    15. These data are consistent with the concept that expression of inhibitory CSPG within the injury scar is an important impediment to regeneration but that NG2+ progenitors derived from ESNLCs can modify the microenvironment PMID: 25713464
    16. NG2 expression in pediatric brain tumors differs depending upon type and, unlike adult glioma, includes expression on lower-grade tumors. PMID: 25503117
    17. The results highlight an unprecedented, complex pattern of NG2/CSPG4 isoform expression in foetal and neoplastic CNS PMID: 24386429
    18. MMP-13 overexpression or exogenous MMP-13 reduces anoikis by more effectively shedding NG2. PMID: 25166220
    19. Reduced promoter methylation and increased expression of CSPG4 are associated with head and neck squamous cell carcinomas. PMID: 24740185
    20. T-cells transduced with a CSPG4-specific chimeric antigen receptor inhibit the growth of CSPG4-expressing tumor cells both in vitro and in vivo. PMID: 24334762
    21. Describe CSPG4-specific immunotoxin that kills rhabdomyosarcoma cells and binds to primary tumor tissues. PMID: 25016058
    22. NG2 knockdown results in loss of beta1 integrin activation in endothelial cells, revealing a mechanism for NG2-dependent cross talk between pericytes and endothelial cells. PMID: 23925489
    23. data suggest that locally produced CSPG4 stimulates human extravillous trophoblast migration and invasion and suggests that IL11 and LIF regulate villous cytotrophoblast differentiation towards the invasive phenotype at least in part via CSPG4. PMID: 23953863
    24. NG2-Col VI interplay as putatively involved in the regulation of the cancer cell-host microenvironment interactions sustaining sarcoma progression PMID: 23559515
    25. This study showed that high CSPG4 expression correlates with disease recurrence and overall survival in breast cancers. PMID: 24177010
    26. Transgenic NG2-positive glia are identified as the major central nervous system cellular target of IL-17 in experimental autoimmune encephalomyelitis. PMID: 23995070
    27. tThis study demonistrated taht human infants, Western blot analyses exhibited trends for lower NG2 levels in the germinal matrix and white matter of infants with Intraventricular hemorrhage relative to controls without Intraventricular hemorrhage. PMID: 23474192
    28. cell polarity complexes as new effectors of NG2 signaling in the establishment of front-rear polarity PMID: 23804106
    29. NG2-positive adipose stem cells loaded on scaffolds fabricate skeletal muscle tissue in vivo without the need of a myogenic pre-differentiation step in vitro. PMID: 23359523
    30. NG2 mediates activation of Rho leading to amoeboid invasiveness in sarcoma cell line. PMID: 22699001
    31. Although transgenic nestin-GFP-expressing progenitor cells share morphological and molecular markers with NG2-glia, they do not express other pericyte markers nor do they differentiate into the muscle lineage. PMID: 22999866
    32. REVIEW outlines recent advances in our understanding of CSPG4-associated cell signaling, describing the central role it plays in melanoma tumor cell growth, motility, and survival, and explores how modifying CSPG4 function and protein-protein interactions may provide us with novel combinatorial therapies for the treatment of advanced melanoma PMID: 22004131
    33. Cell surface P-selectin binding depends on CHST11 gene expression. CSPG4 serves as a P-selectin ligand through its CS chain and participates in P-selectin binding to the highly metastatic breast cancer cells. PMID: 21658254
    34. Findings define the CSPG4-specific fully human scFv-FcC21 antibody as a candidate therapeutic agent to target the many types of tumors that express CSPG4. PMID: 22021902
    35. High NG2 expression is associated with glioblastoma. PMID: 21798846
    36. Functional and clinical relevance of chondroitin sulfate proteoglycan 4. PMID: 21070915
    37. In regions of spinal cord neurodegeneration of amyotrophic lateral sclerosis model mice, NG2-positive cells exhibit enhanced proliferation and accelerated differentiation into oligodendrocytes but remained committed to the oligodendrocyte lineage. PMID: 21092857
    38. Cells that express NG2 proteoglycan act predominantly as a reservoir of new oligodendrocytes in the demyelinated spinal cord. PMID: 21123584
    39. Results showed the expression of MCSP and PRAME in conjunctival melanoma and benign conjunctival nevi and showed that MCSP and PRAME were differentially expressed in both and can help to differentiate the lesions diagnostically. PMID: 20805128
    40. Staining intensity of HMW-MAA in acral lentiginous melanoma lesions was weaker than in superficial spreading melanoma where it was found to be higher than previously reported. PMID: 20448346
    41. in squamous cell carcinoma of head and neck and in basal breast carcinoma, CSPG4 is expressed by cancer stem cells PMID: 20455858
    42. Human skin aging is associated with reduced expression of the stem cell markers beta1 integrin and MCSP PMID: 19776755
    43. identified a novel repeat named CSPG in the central ectodomain PMID: 12220645
    44. Data suggest that MCSP is a novel marker for epidermal stem cells that contributes to their patterned distribution by promoting stem cell clustering. PMID: 14573520
    45. MCSP coexpression with a subset of beta 1 integrin basal keratinocytes within the epidermis suggests that MCSP colocalizes with epidermal stem cells, MSCP expression within the hair follicle was more complex PMID: 15009727
    46. MCSP may facilitate primary melanoma progression by enhancing the activation of key signaling pathways important for tumor invasion and growth. PMID: 15210734
    47. PKC-alpha-mediated NG2 phosphorylation at Thr(2256) is a key step for initiating cell polarization and motility PMID: 15504744
    48. MCSP/NG2 proteoglycan may be considered an important receptor mediating COL6-sarcolemma interactions, a relationship that is disrupted by the pathogenesis of UCMD muscle. PMID: 16169245
    49. tumour cells can regulate both the function and structure of the host-derived tumour vasculature through NG2 expression PMID: 16253523
    50. Co-expression and interaction of NG2 and galectin-3 in human glioma cells establish a molecular basis for the NG2/galectin-3 interaction. PMID: 16365873

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein; Extracellular side. Apical cell membrane; Single-pass type I membrane protein; Extracellular side. Cell projection, lamellipodium membrane; Single-pass type I membrane protein; Extracellular side. Cell surface.
  • 組織特異性:
    Detected only in malignant melanoma cells.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 2466

    OMIM: 601172

    KEGG: hsa:1464

    STRING: 9606.ENSP00000312506

    UniGene: Hs.513044



主站蜘蛛池模板: 麻豆国产成人av高清在线| 亚洲综合色成在线播放| 一本大道无码日韩精品影视丶| 成人亚洲精品久久久久软件| 久久99精品久久久久久齐齐| 99久久无码一区人妻a片蜜| 亚洲大尺度无码无码专线| 97色偷偷色噜噜男人的天堂| 樱花草视频www日本韩国| 1000部拍拍拍18勿入免费视频下载| 菠萝蜜视频在线观看入口| 中文无码精品a∨在线观看不卡| 国产免费人成视频在线播放播| 无码啪啪熟妇人妻区| 巨大欧美黑人xxxxbbbb| 国产精品无码人妻一区二区在线 | 久久精品亚洲一区二区三区浴池| av无码电影一区二区三区| 无码人妻专区免费视频| 在线观看成人无码中文av天堂| 狠狠躁夜夜躁av网站中文字幕| 人人爽人人澡人人高潮| 老湿机国产福利视频| 亚洲精品无码久久久久秋霞 | 精品国产av一二三四区| 无码人妻丰满熟妇区五十路百度| 久久亚洲一区二区三区舞蹈| 九九视频麻婆豆腐在线观看| 拍真实国产伦偷精品| 性猛交ⅹxxx富婆视频| 国产超碰人人爱被ios解锁| 欧美影视精品久久| 国产av无码专区亚汌a√| 深夜福利在线观看视频| 亚洲精品字幕| 亚洲已满18点击进入在线观看| 亚洲欧美国产免费综合视频| 日日摸日日碰人妻无码老牲| 亚洲男人的天堂网站| 欧美亚洲国产第一精品久久| 日本熟妇乱人伦a片免费高清|