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CCL17

CCL17,全稱為C-C motif chemokine ligand 17,也被稱為胸腺活化調(diào)節(jié)趨化因子(TARC),是CC趨化因子家族中的一員。它在人體內(nèi)主要表達(dá)于胸腺,并在植物血凝素(PHA)刺激的外周血單個核細(xì)胞中瞬時表達(dá)。CCL17通過與T細(xì)胞表面的CCR4受體結(jié)合,在免疫細(xì)胞的遷移、激活和炎癥反應(yīng)的調(diào)節(jié)中發(fā)揮重要作用。研究發(fā)現(xiàn),CCL17在多種炎癥和免疫相關(guān)疾病中發(fā)揮作用,如哮喘、骨關(guān)節(jié)炎、多發(fā)性骨髓瘤等。針對CCL17及其受體的藥物研發(fā)已取得一定進(jìn)展,例如阻斷CCL17可減輕小鼠膝骨關(guān)節(jié)炎疼痛和關(guān)節(jié)損傷,提示其在疾病治療中的潛在應(yīng)用價值。

熱銷產(chǎn)品

Recombinant Human C-C motif chemokine 17 (CCL17) (Active) (CSB-MP856406HU)

驗證數(shù)據(jù)

CSB-MP856406HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP856406HU

Activity
Measured by its binding ability in a functional ELISA. Immobilized Anti-CCL17 recombinant antibody (CSB-RA856406MA1HU) at 2 μg/ml can bind Human CCL17 protein. The EC50 is 2.403-2.741 ng/mL.

CCL17 Recombinant Monoclonal Antibody (CSB-RA856406MA1HU)

驗證數(shù)據(jù)

CSB-RA856406MA1HU

The Binding Activity of Human CCL17 with Anti-CCL17 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Anti-CCL17 recombinant antibody at 2 μg/mL can bind Human CCL17 protein (CSB-MP856406HU) . The EC50 is 2.403-2.741 ng/mL.

CSB-RA856406MA1HU

The Binding Activity of Macaca mulatta CCL17 with Anti-CCL17 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Anti-CCL17 recombinant antibody at 2 μg/mL can bind Mouse Ccl17 protein (CSB-MP6512MO). The EC50 is 0.9792-1.486 ng/mL.

CSB-RA856406MA1HU

The Binding Activity of Macaca mulatta CCL17 with Anti-CCL17 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Anti-CCL17 recombinant antibody at 2 μg/mL can bind Macaca mulatta CCL17 protein (CSB-MP811562MOW). The EC50 is 1.953-2.469 ng/mL.

CSB-RA856406MA1HU

Overlay Peak curve showing Raji cells stained with CSB-RA856406MA1HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for?10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was Fluorescein (FITC) AffiniPure Goat Anti-Human IgG, Fcγ fragment specific at 1:200 dilution for 35 min at 4℃.Control antibody (green line) was human IgG1 (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

Human thymus activation regulated chemokine,TARC ELISA Kit (CSB-E09257h)

驗證數(shù)據(jù)

CSB-E09257h 標(biāo)準(zhǔn)曲線

貨號:CSB-E09257h

規(guī)格:96T/48T

靈敏度:3.9 pg/mL

檢測范圍:15.6 pg/mL-1000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

CCL17 Antibodies

CCL17 for Homo sapiens (Human)

CCL17 Proteins

CCL17 Proteins for Macaca mulatta (Rhesus macaque)

CCL17 Proteins for Felis catus (Cat) (Felis silvestris catus)

CCL17 Proteins for Homo sapiens (Human)

CCL17 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

CCL17 ELISA Kit

CCL17 ELISA Kit for Homo sapiens (Human)

CCL17 ELISA Kit for Monkey

CCL17 ELISA Kit for Canis lupus familiaris (Dog) (Canis familiaris)