CASP4
CASP4,全稱胱天冬酶4,是一種參與細胞凋亡和炎癥反應的蛋白酶。該蛋白常見別名包括ICE(rel)II、ICEREL-II、ICH-2、Mih1/TX、TX、Mih1等。CASP4主要通過識別革蘭氏陰性菌脂多糖(LPS)激活非經典炎癥通路,進而切割Gasdermin D(GSDMD)并介導細胞焦亡和炎癥因子釋放。研究發現,CASP4能夠切割AKT1的D108位點,移除其PH自抑制結構域,釋放激酶活性核心,提示細胞焦亡通路可能通過AKT1調控網絡與細胞存活、代謝等進程產生交叉對話。此外,CASP4對同家族蛋白酶Caspase-5/12前體的激活作用,揭示了炎癥性caspase間存在級聯放大機制。CASP4與多種疾病相關,如感染性疾病和炎癥相關疾病。目前,針對CASP4的藥物研發正在積極進行中,例如抗炎藥吲哚布洛芬是CASP4酶活性的抑制劑。此外,CASP4抗體等診斷試劑的研發也為相關疾病的研究提供了有力工具。
熱銷產品
Recombinant Human Caspase-4 (CASP4) (CSB-EP004549HU(A4))
驗證數據
-SDS.jpg)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CASP4 Antibodies
CASP4 for Homo sapiens (Human)
產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
---|---|---|---|
CSB-PA004549GA01HU | CASP4 Antibody | Human | ELISA,WB,IHC |
CSB-PA000023 | Cleaved-CASP4 (Q81) Antibody | Human | WB, IHC, ELISA |
CSB-PA060273 | CASP4 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA004549LA01HU | CASP4 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
CASP4 Proteins
CASP4 Proteins for Mus musculus (Mouse)
產品貨號 | 產品名稱 | 來源 |
---|---|---|
CSB-YP004549MO CSB-EP004549MO CSB-BP004549MO CSB-MP004549MO CSB-EP004549MO-B |
Recombinant Mouse Caspase-4 (Casp4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CASP4 Proteins for Homo sapiens (Human)
產品貨號 | 產品名稱 | 來源 |
---|---|---|
CSB-YP004549HU CSB-EP004549HU CSB-BP004549HU CSB-MP004549HU CSB-EP004549HU-B |
Recombinant Human Caspase-4 (CASP4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP004549HU(A4) | Recombinant Human Caspase-4 (CASP4) | E.coli |
CASP4 Proteins for Bos taurus (Bovine)
產品貨號 | 產品名稱 | 來源 |
---|---|---|
CSB-YP691616BO CSB-EP691616BO CSB-BP691616BO CSB-MP691616BO CSB-EP691616BO-B |
Recombinant Bovine Caspase-4 (CASP4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CASP4 Proteins for Arabidopsis thaliana (Mouse-ear cress)
產品貨號 | 產品名稱 | 來源 |
---|---|---|
CSB-YP866914DOA1 CSB-EP866914DOA1 CSB-BP866914DOA1 CSB-MP866914DOA1 CSB-EP866914DOA1-B |
Recombinant Arabidopsis thaliana Casparian strip membrane protein 4 (CASP4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF866914DOA | Recombinant Arabidopsis thaliana Casparian strip membrane protein 4 (CASP4) | in vitro E.coli expression system |