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BCL6

BCL6蛋白,全稱為B細(xì)胞淋巴瘤6蛋白,也被稱為B細(xì)胞淋巴瘤6、BCL-6等。它是生發(fā)中心的關(guān)鍵轉(zhuǎn)錄抑制因子,參與調(diào)節(jié)多種生物功能和譜系。BCL6蛋白通過(guò)與輔阻遏物和組蛋白脫乙酰酶形成復(fù)合物,直接結(jié)合特定DNA序列,抑制GC B細(xì)胞中參與分化、炎癥、凋亡和細(xì)胞周期控制的基因。BCL6蛋白與多種疾病相關(guān),包括非霍奇金淋巴瘤、濾泡性淋巴瘤和彌漫性大B細(xì)胞淋巴瘤等。在藥物研發(fā)方面,針對(duì)BCL6的小分子抑制劑和PROTAC降解劑正在被研究,以開(kāi)發(fā)新的治療策略。

熱銷產(chǎn)品

Recombinant Human B-cell lymphoma 6 protein (BCL6) (CSB-EP002625HUe1)

驗(yàn)證數(shù)據(jù)

CSB-EP002625HUe1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

BCL6 Recombinant Monoclonal Antibody (CSB-RA131953A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA131953A0HU

IHC image of CSB-RA131953A0HU diluted at 1:33 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.73% DAB.

CSB-RA131953A0HU

Overlay Peak curve showing Jurkat cells stained with CSB-RA131953A0HU (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

Human B-cell leukemia/lymphoma 6,Bcl6 ELISA Kit (CSB-E14975h)

驗(yàn)證數(shù)據(jù)

CSB-E14975h 標(biāo)準(zhǔn)曲線

貨號(hào):CSB-E14975h

規(guī)格:96T/48T

靈敏度:4.68 pg/mL

檢測(cè)范圍:18.75 pg/mL-1200 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

BCL6 Antibodies

BCL6 for Homo sapiens (Human)

BCL6 Proteins

BCL6 Proteins for Mus musculus (Mouse)

BCL6 Proteins for Homo sapiens (Human)

BCL6 Proteins for Gallus gallus (Chicken)

BCL6 ELISA Kit

BCL6 ELISA Kit for Homo sapiens (Human)



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