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AVPR2

AVPR2,即精氨酸加壓素受體2,別名V2R、DI1、DIR、NDI、ADHR、DIR3、NDI1。AVPR2由人類(lèi)AVPR2基因編碼,該基因位于X染色體上。AVPR2是一種七跨膜域G蛋白偶聯(lián)受體(GPCR)超家族的成員,與Gs蛋白耦聯(lián),從而刺激腺苷酸環(huán)化酶。AVPR2主要在腎臟的遠(yuǎn)端小管和集合管中表達(dá),其主要功能是響應(yīng)垂體激素精氨酸加壓素(AVP),通過(guò)刺激機(jī)制使尿液濃縮,維持體內(nèi)水分平衡。當(dāng)AVPR2的功能喪失時(shí),會(huì)導(dǎo)致腎源性尿崩癥(NDI)。AAVPR2的基因表達(dá)也與肺組織的發(fā)育和肺癌相關(guān)。

熱銷(xiāo)產(chǎn)品

AVPR2 Antibody (CSB-PA002470LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA002470LA01HU

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA002470LA01HU at dilution of 1:100

CSB-PA002470LA01HU

Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA002470LA01HU at dilution of 1:100

CSB-PA002470LA01HU

Immunofluorescence staining of MCF-7 cells with CSB-PA002470LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

AVPR2 Antibodies

AVPR2 for Homo sapiens (Human)

AVPR2 for Pig

AVPR2 Proteins

AVPR2 Proteins for Rattus norvegicus (Rat)

AVPR2 Proteins for Sus scrofa (Pig)

AVPR2 Proteins for Homo sapiens (Human)

AVPR2 Proteins for Bos taurus (Bovine)

AVPR2 Proteins for Mus musculus (Mouse)

AVPR2 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)