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ASPH

天冬氨酰β-羥化酶(ASPH)又稱HAAH,是一種催化蛋白質(zhì)羥基化反應(yīng)的酶,主要通過對(duì)天冬氨酸或天冬酰胺殘基進(jìn)行修飾,影響細(xì)胞黏附與運(yùn)動(dòng)能力。ASPH在多種惡性腫瘤中異常高表達(dá),尤其在肝癌、胰腺癌和乳腺癌中,其活性增強(qiáng)會(huì)加速腫瘤細(xì)胞侵襲轉(zhuǎn)移,并與患者較差的生存率密切相關(guān)。ASPH通過激活Notch、HIF-1α等分子網(wǎng)絡(luò),促進(jìn)血管新生和腫瘤微環(huán)境重塑,同時(shí)與TGF-β協(xié)同驅(qū)動(dòng)上皮間質(zhì)轉(zhuǎn)化過程。
近年來,ASPH成為抗癌藥物開發(fā)的熱點(diǎn)靶點(diǎn)。小分子抑制劑如MO-I-1151已在臨床前研究中顯示出阻斷腫瘤生長(zhǎng)的潛力,而單克隆抗體藥物JCTN-1通過特異性結(jié)合ASPH抑制其酶活性,目前處于早期臨床試驗(yàn)階段。基于CRISPR的基因編輯技術(shù)也在探索靶向沉默ASPH的可能性部分肝癌患者中ASPH表達(dá)水平與索拉非尼耐藥性存在關(guān)聯(lián),這為聯(lián)合用藥策略提供了新方向。

熱銷產(chǎn)品

Recombinant Human Aspartyl/asparaginyl beta-hydroxylase (ASPH), partial (CSB-EP002226HU)

驗(yàn)證數(shù)據(jù)

CSB-EP002226HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-EP002226HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP002226HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) ASPH.

CSB-EP002226HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP002226HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) ASPH.

ASPH Antibody (CSB-PA002226HA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA002226HA01HU

Western Blot
Positive WB detected in: A549 whole cell lysate, HepG2 whole cell lysate, Mouse kidney tissue
All lanes: ASPH antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 86, 35, 26, 24, 34, 84, 30, 22, 29, 33 kDa
Observed band size: 86 kDa

CSB-PA002226HA01HU

IHC image of CSB-PA002226HA01HU diluted at 1:300 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA002226HA01HU

IHC image of CSB-PA002226HA01HU diluted at 1:300 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA002226HA01HU

Immunofluorescence staining of Hela cells with CSB-PA002226HA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

ASPH Antibodies

ASPH for Homo sapiens (Human)

ASPH Proteins

ASPH Proteins for Homo sapiens (Human)



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