在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ASPH Antibody

  • 中文名稱:
    ASPH兔多克隆抗體
  • 貨號:
    CSB-PA002226GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    ASPH antibody; BAHAspartyl/asparaginyl beta-hydroxylase antibody; EC 1.14.11.16 antibody; Aspartate beta-hydroxylase antibody; ASP beta-hydroxylase antibody; Peptide-aspartate beta-dioxygenase antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Human ASPH
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins.; membrane-bound Ca(2+)-sensing protein, which is a structural component of the ER-plasma membrane junctions. Isoform 8 regulates the activity of Ca(+2) released-activated Ca(+2) (CRAC) channels in T-cells.
  • 基因功能參考文獻:
    1. the role of FTH1 in the FIH control of HIF-1 activity, is reported. PMID: 29580991
    2. the hydroxylase activity of ASPH affected HCC metastasis through interacting with vimentin and regulating EMT. As such, ASPH might be a promising therapeutic target of HCC. PMID: 29764768
    3. Higher levels of HAAH/humbug mRNA were found in the hepatocellular carcinoma tissues relative to the adjacent cancerfree tissue. PMID: 25394783
    4. this study provides evidence that ASPH is mutated in a distinct form of syndromic ectopia lentis. PMID: 24768550
    5. Data show that junctate (ASPH) is an interacting partner of Orai1-STIM1 complex. PMID: 22586105
    6. Ca(2+) and JNT-dependent disassembly of the CSQ2 polymer PMID: 22123818
    7. Aspartyl-asparaginyl-beta-hydroxylase is an important, positive regulator of trophoblastic cell motility, and it's inhibition in vivo leads to impaired implantation and fetal growth, and alters Notch-signaling mechanisms. PMID: 21862239
    8. Low expression of AAH in the endochylema and nucleus of trephocyte may play a role in patients with missed abortion. PMID: 19197126
    9. role of gene in neuroblastoma cell motility PMID: 12118090
    10. AAH over-expression may contribute to the infiltrative growth pattern of cholangiocarcinoma cells by promoting motility. PMID: 12713872
    11. junctate has a role in calcium homeostasis in eukaryotic cells PMID: 15302852
    12. This review summarizes recent progress in elucidating the molecular mechanisms of hypoxia-inducible factor (HIF)-1 activation, focusing on the role of oxygen-dependent prolyl hydroxylase in hypoxia signal transduction. PMID: 16154531
    13. Overexpression of aspartyl beta-hydroxylase plays a role in the development and progression of hepatocellular carcinoma. PMID: 16341145
    14. enhanced AAH gene activity is a common feature of human hepatocellular carcinoma and growth factor signaling through IRS-1 regulates AAH expression and increases cell motility and invasion PMID: 16564107
    15. Human aspartyl (asparaginyl) beta-hydroxylase (HAAH) mRNA is overexpressed in biliary cancer cell lines and possibly involved in the pathogenesis of bile duct cancer. PMID: 16673309
    16. Abundant AAH expression in trophoblasts as well as in decidua and endometrial glands, with reduced expression in spontaneous abortion and small-for-gestational-age term deliveries, suggesting that AAH may serve as a biomarker of impaired implantation. PMID: 16949909
    17. Study demonstrates that high levels of humbug immunoreactivity in colon carcinomas correlate with histologic grade and tumor behavior, suggesting that humbug can serve as a prognostic biomarker. PMID: 17020779
    18. AAH and Humbug are over-expressed in SH-Sy5y neuroblastoma cells, and their mRNAs are regulated by insulin/IGF-1 signaling through Erk MAPK, PI3 kinase-Akt, and Cdk-5, which are known mediators of cell migration. PMID: 17156427
    19. Expression analysis showed that the mRNA expression level of humbug was correlated with invasive potential in various human gastric cancer cell lines. PMID: 18288418
    20. USF1 and USF2 positively regulate the core of P1 promoter od AAH. PMID: 19087304
    21. High levels of aspartyl (asparaginyl)-beta-hydroxylase/humbug correlate with poor prognosis in non-small cell lung cancer, particularly squamous cell carcinoma subtype. PMID: 19200576
    22. analysis of aspartyl (asparaginyl) beta-hydroxylase monoclonal antibodies PMID: 19663697

    顯示更多

    收起更多

  • 相關疾病:
    Facial dysmorphism, lens dislocation, anterior segment abnormalities, and spontaneous filtering blebs (FDLAB)
  • 亞細胞定位:
    [Isoform 1]: Endoplasmic reticulum membrane; Single-pass type II membrane protein.; [Isoform 4]: Sarcoplasmic reticulum membrane; Single-pass type II membrane protein.; [Isoform 8]: Endoplasmic reticulum membrane; Single-pass type II membrane protein.
  • 蛋白家族:
    Aspartyl/asparaginyl beta-hydroxylase family
  • 組織特異性:
    Isoform 1 is detected in all tissues tested. Isoform 8 is mainly expressed in pancreas, heart, brain, kidney and liver. Isoform 8 is expressed in kidney (at protein level).
  • 數據庫鏈接:

    HGNC: 757

    OMIM: 600582

    KEGG: hsa:444

    STRING: 9606.ENSP00000368767

    UniGene: Hs.332422



主站蜘蛛池模板: 日韩精品电影综合区亚洲| 国产精品亚洲精品日韩已满十八小 | 久热国产精品视频一区二区三区| 麻豆亚洲一区| 无码免费午夜福利看片| 国产午夜免费高清久久影院 | 欧美丰满老熟妇aaaa片| 噜噜色综合噜噜色噜噜色| 免费无码av片在线观看国产| 在线亚洲中文精品第1页| 日韩精品一区二区三区视频| 强开小婷嫩苞又嫩又紧视频韩国| 真实国产乱子伦精品一区二区三区| 成人亚洲a片v一区二区三区动漫| 无码国产精品一区二区免费i6| 日韩 无码 偷拍 中文字幕| 日韩内射激情视频在线播放免费| 丰满多毛少妇做爰视频爽爽和| 三级4级全黄60分钟| 亚洲伊人久久大香线蕉综合图片 | 超碰成人人人做人人爽| 加勒比久久综合网天天| 日韩精品乱码av一区二区| 亚洲精品久久av无码一区二区| 午夜一区一品日本| 成人亚洲精品久久久久软件| 中文字日产乱码免费1~3软件 | 亚洲精品黑牛一区二区三区| 97超级碰碰人妻中文字幕 | 777米奇影视第四色| 国产精品自在线一区| 久久久久久久性潮| 日本老妇人乱xxy| 国产主播一区二区三区在线观看| 欧美性猛交xxxx乱大交| 精品亚洲一区二区三区在线观看| 久久国产精品萌白酱免费| 国产农村妇女高潮大叫| 亚洲国产欧美国产综合一区| 精品无码中文字幕在线| 欧美乱强伦xxxx孕妇|