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AKAP8

AKAP8 is a protein in humans that is encoded by AKAP8 gene. Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring. May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression. Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L. Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation.

AKAP8 Antibodies

AKAP8 for Homo sapiens (Human)

AKAP8 Proteins

AKAP8 Proteins for Homo sapiens (Human)

AKAP8 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

AKAP8 Proteins for Rattus norvegicus (Rat)

AKAP8 Proteins for Mus musculus (Mouse)



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