在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. AKAP8 Antibody

AKAP8 Antibody

  • 中文名稱：
    AKAP8兔多克隆抗體
  • 貨號：
    CSB-PA091575
  • 規格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from mouse heart cells and Jurkat cells, using AKAP8 antibody.
    • Immunohistochemistry analysis of paraffin-embedded human heart tissue using AKAP8 antibody.
    • Immunofluorescence analysis of HUVEC cells, using AKAP8 antibody.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) AKAP8 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from internal of Human AKAP8.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC,IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
    IF 1:100-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring. May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression. Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L. Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation. May be involved in regulation of DNA replication by acting as scaffold for MCM2. Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation. In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation. May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells. May act as a carrier protein of GJA1 for its transport to the nucleus. May play a repressive role in the regulation of rDNA transcription. Preferentially binds GC-rich DNA in vitro. In cells, associates with ribosomal RNA (rRNA) chromatin, preferentially with rRNA promoter and transcribed regions. Involved in modulation of Toll-like receptor signaling. Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation; the function probably implicates targeting of PKA to NFKB1.
  • 基因功能參考文獻：
    1. These results establish AKAP95 as a mostly positive regulator of pre-mRNA splicing and a possible integrator of transcription and splicing regulation. PMID: 27824034
    2. Results suggest that ALK generated by alternative transcription Initiation induces chromatin structural changes and heterochromatinization through phosphorylation of AKAP8 in the nucleus. PMID: 29093346
    3. Using a BioID proximity-based proteomic screen, we identify the nuclear pore complex protein TPR as a novel AKAP95 binding partner. We show interaction between AKAP95 and TPR in mitosis, and an AKAP95-dependent enrichment of TPR in the spindle microtubule area in metaphase, then later in the spindle midzone area. PMID: 28379780
    4. Report expression of connexin 43 in ovarian cancer cells in G1/S phase. PMID: 26823747
    5. The data indicate that AKAP95 is a novel nucleolus-associated protein with a regulatory role on rRNA production. PMID: 26683827
    6. Gene dosage at 19p13.12, and AKAP8 and/or AKAP8L in particular, play an important role in modulation of head size and may contribute to autism risk. PMID: 26076356
    7. These results suggest that AKAP8 is involved in the regulation of chromatin structural changes through nuclear tyrosine phosphorylation. PMID: 25770215
    8. Ectopic AKAP95 stimulates expression of a chromosomal reporter gene in synergy with MLL1 or MLL2, whereas AKAP95 depletion impairs retinoic acid-mediated gene induction in embryonic stem cells PMID: 23995757
    9. AMY-1 interacts with S-AKAP84 and this protein in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex. PMID: 12414807
    10. role of AKAP95 in DNA replication by providing a scaffold for MCM2 PMID: 12740381
    11. AKAP95 is a potential carrier protein for active caspase 3 from the cytoplasm into the nuclei in apoptotic cells. PMID: 16227597

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Nucleus matrix. Nucleus, nucleolus. Cytoplasm.
  • 蛋白家族：
    AKAP95 family
  • 組織特異性：
    Highly expressed in heart, liver, skeletal muscle, kidney and pancreas. Expressed in mature dendritic cells.
  • 數據庫鏈接：

    HGNC: 378

    OMIM: 604692

    KEGG: hsa:10270

    STRING: 9606.ENSP00000269701

    UniGene: Hs.594496



主站蜘蛛池模板： 88国产精品视频一区二区三区| 少妇人妻综合久久中文| 欧美xxxx做受欧美人妖| 国产熟妇另类久久久久| 精品国产不卡一区二区三区| 亚 洲 成 人 网站在线观看| 久久天天躁狠狠躁夜夜96流白浆| 久久综合香蕉国产蜜臀av| 国产精品96久久久久久| 18禁亚洲深夜福利入口| 久久99九九精品久久久久蜜桃| 黄网在线观看免费网站| 亚洲成av人在线播放无码| 中日韩精品无码一区二区三区| 精品国产天堂综合一区在线| 欧美一区二区三区成人久久片| 亚洲欧洲美色一区二区三区| 99久视频只有精品2019| 久久精品国产一区二区电影| 色偷偷88888欧美精品久久久| 伊人久久大香线蕉av最新| 国产午夜福利小视频合集| 国产精品午夜无码av天美传媒| 亚洲熟妇无码八av在线播放| 久久免费视频精品在线| 亚洲人色婷婷成人网站在线观看| 国产乱码精品一区二区三区中文| 色婷婷国产精品高潮呻吟av久久| 极品少妇被弄得高潮不断| 午夜福利电影| 精品人妻一区二区三区四区在线| 亚洲乱码av中文一区二区软件| 欧美性白人极品1819hd| 午夜精品久久久久久久99热| 亚洲 日本 欧美 中文字幕| 日本又黄又爽又色又刺激的视频| 亚洲 成人 无码 在线观看| 国产清纯白嫩初高生在线观看| 春色校园亚洲愉拍自拍| 亚洲精品无码一区二区| 精品国内自产拍在线播放观看|